Protein Alignment CYP26A1 and Cyp4e1

DIOPT Version :10

• Sequence 1: NP_000774.2
• Gene: CYP26A1 / 1592
• HGNCID: 2603
• Length: 497
• Species: Homo sapiens
• Sequence 2: NP_524771.1
• Gene: Cyp4e1 / 44632
• FlyBaseID: FBgn0015034
• Length: 531
• Species: Drosophila melanogaster
• Alignment Length: 529
• Identity: 115/529 - (21%)
• Similarity: 206/529 - (38%)
• Gaps: 90/529 - (17%)

Human    27 LWDLYCVSGRDRSCALPLPPGTMGFPFFGETLQMVLQRRKFLQMKRRKYG-----FIYKTHLFGR 86
            :|.:.|.     ..||||        |.....::.|.|||  :|..:..|     .:...|..|.
  Fly     1 MWIVLCA-----FLALPL--------FLVTYFELGLLRRK--RMLNKFQGPSMLPLVGNAHQMGN 50

Human    87 PTVRVM----------GADNVRRILLGEHRLVSVHWPASVRTILGSGCL---SNLHDSSH----- 133
            ....::          |.||. |..:|.:..:.|..|..:..||.|..|   |:::|.:|
  Fly    51 TPTEILNRFFGWWHEYGKDNF-RYWIGYYSNIMVTNPKYMEFILSSQTLISKSDVYDLTHPWLGL 114

Human   134 ----------KQRKKVIMRAFSREALECYVPVITEEVGSSLEQWLSCGERGLL--VYPEVKRLMF 186
                      .:.:|:|..||....|:.:..|:.|.....::|.....:.|.:  ...|...|..
  Fly   115 GLLTSTGSKWHKHRKMITPAFHFNILQDFHEVMNENSTKFIDQLKKVADGGNIFDFQEEAHYLTL 179

Human   187 RIAMRILLGCEPQLAGDGDSEQQLVEAFEEMT------------RN--LFSLPIDVP-FSGLYRG 236
            .:.....:|.......:..|  .:|:||:::|            ||  ||....:.| :|...:.
  Fly   180 DVICDTAMGVSINAMENRSS--SVVQAFKDITYTIKMRAFSPWKRNKYLFHFAPEYPEYSKTLKT 242

Human   237 MK--ARNLIHARIEQNIRAKICGLRASEAGQGCKDALQLLIEHSWERGERLDMQALKQSSTELLF 299
            ::  ...:|..|||........|::|.|..:.....|..|:....: |..|..|.|.:..:..:|
  Fly   243 LQDFTNEIIAKRIEVRKSGLEVGIKADEFSRKKMAFLDTLLSSKVD-GRPLTSQELYEEVSTFMF 306

Human   300 GGHETTASAATSLITYLGLYPHVLQKVREE----LKSKGLLCKSNQDNKLDMEILEQLKYIGCVI 360
            .||:||.|.....:..|..:|...:|:..|    :.:.||      ......:.:..:|::...|
  Fly   307 EGHDTTTSGVGFAVYLLSRHPDEQEKLFNEQCDVMGASGL------GRDATFQEISTMKHLDLFI 365

Human   361 KETLRLNPPVPGGFRVALKTFELNGYQIPKGWNVIYSICDTHDVAEIFTNKEEFNPDRFMLPHPE 425
            ||..||.|.||...|...|.:.::|..:|||..:...:........:|.:..:|.|:||   ..|
  Fly   366 KEAQRLYPSVPFIGRFTEKDYVIDGDIVPKGTTLNLGLLMLGYNDRVFKDPHKFQPERF---DRE 427

Human   426 DASRFSFIPFGGGLRSCVGKEFAKILLKIFTVELARHCDW-----QLLNGPPTMKTSPTVYPVDN 485
            ....|.::||..|.|:|:|::||.:.:|....::.|:.:.     :|::....:.|:..:.|.:.
  Fly   428 KPGPFEYVPFSAGPRNCIGQKFALLEIKTVVSKIIRNFEVLPALDELVSKDGYISTTLGLQPAEK 492

Human   486 LPARFTHFH 494
             .:|..|.|
  Fly   493 -KSRDAHNH 500

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CYP26A1	NP_000774.2	CYP26A1	55..490	CDD:410731	105/495 (21%)
Cyp4e1	NP_524771.1	CYP4	68..520	CDD:410721	99/447 (22%)