DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CYP26A1 and Cyp9f2

DIOPT Version :9

Sequence 1:	NP_000774.2	Gene:	CYP26A1 / 1592	HGNCID:	2603	Length:	497	Species:	Homo sapiens
Sequence 2:	NP_650189.1	Gene:	Cyp9f2 / 41520	FlyBaseID:	FBgn0038037	Length:	516	Species:	Drosophila melanogaster

Alignment Length:	517	Identity:	117/517 - (22%)
Similarity:	191/517 - (36%)	Gaps:	137/517 - (26%)

- Green bases have known domain annotations that are detailed below.

Human    27 LWDLYCVSG-----------------RDRSCALPLPPGTMGFPFFGETLQMVLQRRKFLQMKRRK 74
            ||:.:.:..                 :||..|...|     ..:||....|.|::|....:....
  Fly     2 LWEFFALFAIAAALFYRWASANNDFFKDRGIAYEKP-----VLYFGNMAGMFLRKRAMFDIVCDL 61

Human    75 YGFIYKTHLFG-----RPTVRVMGADNVRRILLGE------HRLV----SVHWPASVRTILGSGC 124
            |........||     :|.:.|...|.:::|.:.:      ||.|    |...|..:..:.||.
  Fly    62 YTKGGSKKFFGIFEQRQPLLMVRDPDLIKQITIKDFDHFINHRNVFATSSDDDPHDMSNLFGSS- 125

Human   125 LSNLHDSSHKQRKKVIMRAF---------------SREALEC-----------------YVPVIT 157
            |.::.|:..|..:..:..||               ::||::|                 |....|
  Fly   126 LFSMRDARWKDMRSTLSPAFTGSKMRQMFQLMNQVAKEAVDCLKQDDSRVQENELDMKDYCTRFT 190

Human   158 EEVGSSLE---QWLSCGERGLLVYPEVKRL---MFRIAMRILLGCEPQLAGDGDSEQQLVEAFEE 216
            .:|.:|..   |..|..:|....|...|:|   .|..:|:.:|    ..|..|.::...||.|:.
  Fly   191 NDVIASTAFGLQVNSFKDRENTFYQMGKKLTTFTFLQSMKFML----FFALKGLNKILKVELFDR 251

Human   217 MTRNLF-SLPIDVPFSGLYRGMKARNLIHARIEQNIRAKICGLRASEAGQGCKDALQLLIEHSWE 280
            .:...| .|.:|        .||.|.      |.||      :|        .|.:.:|:|   .
  Fly   252 KSTQYFVRLVLD--------AMKYRQ------EHNI------VR--------PDMINMLME---A 285

Human   281 RG----ERLDMQALKQSSTE--------LLFGGHETTASAATSLITYLGLYPHVLQKVREELKSK 333
            ||    |:....|:::.|..        ..|.|.||:|.........|.....|.|::.||::
  Fly   286 RGIIQTEKTKASAVREWSDRDIVAQCFVFFFAGFETSAVLMCFTAHELMENQDVQQRLYEEVQ-- 348

Human   334 GLLCKSNQD---NKLDMEILEQLKYIGCVIKETLRLNPPVPGGFRVALK--TFELNG--YQIPKG 391
                :.:||   .:|..|.:..:||:..|:.|.||..|......|...|  ||:::|  .::.||
  Fly   349 ----QVDQDLEGKELTYEAIMGMKYLDQVVNEVLRKWPAAIAVDRECNKDITFDVDGQKVEVKKG 409

Human   392 WNVIYSICDTHDVAEIFTNKEEFNPDRFMLPHPEDASRFSFIPFGGGLRSCVGKEFAKILLK 453
            ..:....|..|...:.|.|..:|:|:||...:.|....|::.|||.|.|:|:|..||.:..|
  Fly   410 DVIWLPTCGFHRDPKYFENPMKFDPERFSDENKESIQPFTYFPFGLGQRNCIGSRFALLEAK 471

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CYP26A1	NP_000774.2	p450	14..492	CDD:299894	117/517 (23%)
Cyp9f2	NP_650189.1	p450	36..510	CDD:278495	112/483 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2429
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.030