DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CYP26A1 and Cyp4d8

DIOPT Version :9

Sequence 1:	NP_000774.2	Gene:	CYP26A1 / 1592	HGNCID:	2603	Length:	497	Species:	Homo sapiens
Sequence 2:	NP_523961.2	Gene:	Cyp4d8 / 38841	FlyBaseID:	FBgn0015033	Length:	505	Species:	Drosophila melanogaster

Alignment Length:	500	Identity:	128/500 - (25%)
Similarity:	213/500 - (42%)	Gaps:	73/500 - (14%)

- Green bases have known domain annotations that are detailed below.

Human    14 FVLPLLLFLAAIKLWDLYCVSGRDRSCALPLPPGTMGFPFFGE-TLQMVLQRRKFLQMKRR---K 74
            |:|.:|||.|.   |.:: :...||...:...||.:..|..|. .|.:.|..:.|:::.|.   |
  Fly     4 FLLVVLLFGAG---WIIH-LGQADRRRKVANLPGPICPPLIGAMQLMLRLNPKTFIKVGREYVLK 64

Human    75 YGFIYKTHLFGRPTVRVMGADNVRRILLGEHRLVSVH--------WPASVRTILGSGCLSNLHDS 131
            :|.:.:..:|.|..:....|:...::|..:..||. |        |       ||:|.|  |.|.
  Fly    65 FGHLQRVWIFNRLLIMSGDAELNEQLLSSQEHLVK-HPVYKVLGQW-------LGNGLL--LSDG 119

Human   132 S--HKQRKKVIMRAFSREALECYVPVITEEVGSSLEQWLSCGERGLL-VYPEVKRLMFRIAMRIL 193
            .  | ||:|:|...|....||.:|.|..::....:::.......... ||..:......|.....
  Fly   120 KVWH-QRRKIITPTFHFSILEQFVEVFDQQSNICVQRLAQKANGNTFDVYRSICAAALDIIAETA 183

Human   194 LGCEPQLAGDGDSEQQLVEAFEEMTRNL------FSLPIDVPFSGLYRGMKARNLIHARIEQNIR 252
            :|  .::....:......||..|.|..|      ..|.:::.|:..:..:|.|.....|..|...
  Fly   184 MG--TKIYAQANESTPYAEAVNECTALLSWRFMSVYLQVELLFTLTHPHLKWRQTQLIRTMQEFT 246

Human   253 AKICGLR-------------ASEAGQGCKDALQLL--IEHSWERGERLDMQALKQSSTELLFGGH 302
            .|:...|             .::...|.|..:.||  :..|...|..|....:::.....:|.||
  Fly   247 IKVIEKRRQALEDQQSKLMDTADEDVGSKRRMALLDVLLMSTVDGRPLTNDEIREEVDTFMFEGH 311

Human   303 ETTASAATSLITYLGLYPHVLQKVREELKSKGLLCKSNQDNKLDMEILEQLKYIGCVIKETLRLN 367
            :||.||.:..:..|..:|.|..|:.||:..   :..:::...:.:..|.:|||:.|||||:||:.
  Fly   312 DTTTSALSFCLHELSRHPEVQAKMLEEIVQ---VLGTDRSRPVSIRDLGELKYMECVIKESLRMY 373

Human   368 PPVPGGFRVALKTFEL------NGYQIPKGWNVIYSICDTHDVAEIFTNKEEFNPDRFMLPHPED 426
            ||||...|.....|:.      :|. ||.|..:|..|...|...|.|.|.:||.|:|.     |:
  Fly   374 PPVPIVGRKLQTDFKYTHSVHGDGV-IPAGSEIIIGIFGVHRQPETFPNPDEFIPERH-----EN 432

Human   427 ASR---FSFIPFGGGLRSCVGKEFAKILLKIFTVELARHCDWQLL 468
            .||   |..|||..|.|:|:|::||::.:|:...::.|  :::||
  Fly   433 GSRVAPFKMIPFSAGPRNCIGQKFAQLEMKMMLAKIVR--EYELL 475

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CYP26A1	NP_000774.2	p450	14..492	CDD:299894	127/499 (25%)
Cyp4d8	NP_523961.2	CYP4	66..497	CDD:410721	109/433 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S4598
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2429
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.890