Protein Alignment CYP26A1 and Cyp4d1

DIOPT Version :9

• Sequence 1: NP_000774.2
• Gene: CYP26A1 / 1592
• HGNCID: 2603
• Length: 497
• Species: Homo sapiens
• Sequence 2: NP_476907.2
• Gene: Cyp4d1 / 31188
• FlyBaseID: FBgn0005670
• Length: 512
• Species: Drosophila melanogaster
• Alignment Length: 531
• Identity: 131/531 - (24%)
• Similarity: 216/531 - (40%)
• Gaps: 107/531 - (20%)

Human     5 ALLASALCTFVLPLLLFLAAIKLWDLYCVSGRDRSCALPLPPGTMGFPFFGETLQMVLQRRKFLQ 69
            |:|||||  ||..||..|...:|.||           :...||....|..|
  Fly     7 AILASAL--FVGLLLYHLKFKRLIDL-----------ISYMPGPPVLPLVG-------------- 44

Human    70 MKRRKYGFIYKTHLFGRPT----------VRVMGADNVRRILLGEHRLVSVHWPASVRTILGS-- 122
                     :..|..|:|.          :.....|.|.::.||....|.:..|..|..:||:
  Fly    45 ---------HGHHFIGKPPHEMVKKIFEFMETYSKDQVLKVWLGPELNVLMGNPKDVEVVLGTLR 100

Human   123 -----------------GCLSNLHDSSHKQRKKVIMRAFSREALECYVPVITEEVGS-----SLE 165
                             |.|.:.....|| |:|:|..||..:.|:.:|.|.  |.||     ::|
  Fly   101 FNDKAGEYKALEPWLKEGLLVSRGRKWHK-RRKIITPAFHFKILDQFVEVF--EKGSRDLLRNME 162

Human   166 Q-WLSCGERGLLVYPEVKRLMFRIAMRILLGCEPQLAGDGDSEQ-QLVEAF-----EEMTRNLFS 223
            | .|..|:.|..:|..:............:|.......:.|||. |.|:..     :.|...|:.
  Fly   163 QDRLKHGDSGFSLYDWINLCTMDTICETAMGVSINAQSNADSEYVQAVKTISMVLHKRMFNILYR 227

Human   224 LPIDVPFSGLYRG-MKARNLIHARIEQNI---RAKICGLRASEAGQGCKD-----------ALQL 273
            ..:....:.|.|. .||.|::|...|:.|   |.::  :|...:.:...|           .|.:
  Fly   228 FDLTYMLTPLARAEKKALNVLHQFTEKIIVQRREEL--IREGSSQESSNDDADVGAKRKMAFLDI 290

Human   274 LIEHSWERGER-LDMQALKQSSTELLFGGHETTASAATSLITYLGLYPHVLQKVREELKSKGLLC 337
            |::.:.:  || |....:::.....:|.||:||:||.......:..:|...:|..||::|   :.
  Fly   291 LLQSTVD--ERPLSNLDIREEVDTFMFEGHDTTSSALMFFFYNIATHPEAQKKCFEEIRS---VV 350

Human   338 KSNQDNKLDMEILEQLKYIGCVIKETLRLNPPVPGGFRVALKTFELNGYQIPKGWNVIYSICDTH 402
            .:::...:..|:|.||.|:...:|||||:.|.||...|..|:..|:||..||.|.|:..|.....
  Fly   351 GNDKSTPVSYELLNQLHYVDLCVKETLRMYPSVPLLGRKVLEDCEINGKLIPAGTNIGISPLYLG 415

Human   403 DVAEIFTNKEEFNPDRF-MLPHPEDASRFSFIPFGGGLRSCVGKEFAKILLKIFTVELARHCDWQ 466
            ...|:|:....|.|:|| ::...|..:.:::|||..|.|:|:|::||.:.:|.....:.||.:..
  Fly   416 RREELFSEPNIFKPERFDVVTTAEKLNPYAYIPFSAGPRNCIGQKFAMLEIKAIVANVLRHYEVD 480

Human   467 LL---NGPPTM 474
            .:   :.||.:
  Fly   481 FVGDSSEPPVL 491

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CYP26A1	NP_000774.2	p450	14..492	CDD:299894	125/522 (24%)
Cyp4d1	NP_476907.2	p450	35..507	CDD:278495	117/490 (24%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910