DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CYP26A1 and Cyp4g1

DIOPT Version :9

Sequence 1:	NP_000774.2	Gene:	CYP26A1 / 1592	HGNCID:	2603	Length:	497	Species:	Homo sapiens
Sequence 2:	NP_525031.1	Gene:	Cyp4g1 / 30986	FlyBaseID:	FBgn0010019	Length:	556	Species:	Drosophila melanogaster

Alignment Length:	550	Identity:	133/550 - (24%)
Similarity:	212/550 - (38%)	Gaps:	141/550 - (25%)

- Green bases have known domain annotations that are detailed below.

Human     8 ASALCTFVL---PLLL----FLAAIKLWDLYCVSGRD-RSCA-LPLPPGTMGFPFFGET-LQMVL 62
            ||:..|.||   |:|.    .|.|:.|::.:..:.|: |..| :|.||   ..|..|:. :...|
  Fly    14 ASSSSTTVLGFSPMLTTLVGTLVAMALYEYWRRNSREYRMVANIPSPP---ELPILGQAHVAAGL 75

Human    63 QRRKFLQM---KRRKYGFIYKTHLFGRPTVRVMGADNVRRILLGEHRLVSVHWPASVRTILGSGC 124
            ...:.|.:   ...|||...|..|.....|.:....::..||.|...|.........:...|.|.
  Fly    76 SNAEILAVGLGYLNKYGETMKAWLGNVLLVFLTNPSDIELILSGHQHLTKAEEYRYFKPWFGDGL 140

Human   125 L-SNLHDSSHKQRKKVIMRAFSREALECYVPVITE-----------EVGSSLE--QWLS------ 169
            | ||.|...|  .:|:|...|.:..|:.:||...:           |.|.|.:  .::|
  Fly   141 LISNGHHWRH--HRKMIAPTFHQSILKSFVPTFVDHSKAVVARMGLEAGKSFDVHDYMSQTTVDI 203

Human   170 -----CGERGL------------------LVYPEVKRLMFRI---------------AMRILLGC 196
                 .|.:.|                  :::....:|::|:               .|.|:||.
  Fly   204 LLSTAMGVKKLPEGNKSFEYAQAVVDMCDIIHKRQVKLLYRLDSIYKFTKLREKGDRMMNIILGM 268

Human   197 EPQLAGDGDSEQQLVEAFEEMTRNLFSLPIDVPFSGLYRGMKARNLIHARIEQNIRAKICGLR-- 259
            ..::..|..      |.|:|.:|.:.. .|..|.:......|.                 |||
  Fly   269 TSKVVKDRK------ENFQEESRAIVE-EISTPVASTPASKKE-----------------GLRDD 309

Human   260 ---ASEAGQGCKDALQLL-----------IEHSWERGERLDMQALKQSSTELLFGGHETTASAAT 310
               ..|...|.|..|.||           ||  |...:.:|      ....::|.||:||::.::
  Fly   310 LDDIDENDVGAKRRLALLDAMVEMAKNPDIE--WNEKDIMD------EVNTIMFEGHDTTSAGSS 366

Human   311 SLITYLGLYPHVLQKVREELKSKGLLCKSNQDNKL-DMEILE--QLKYIGCVIKETLRLNPPVPG 372
            ..:..:|::..:..||..|.|:      ...||.| |....:  ::||:..||.|||||.||||
  Fly   367 FALCMMGIHKDIQAKVFAEQKA------IFGDNMLRDCTFADTMEMKYLERVILETLRLYPPVP- 424

Human   373 GFRVALK-TFEL----NGYQIPKGWNVIYSICDTHDVAEIFTNKEEFNPDRFMLPHPEDASRFSF 432
              .:|.: .::|    ..|.:|||..||......|...:|:.|..:|:||.|:.....:...:||
  Fly   425 --LIARRLDYDLKLASGPYTVPKGTTVIVLQYCVHRRPDIYPNPTKFDPDNFLPERMANRHYYSF 487

Human   433 IPFGGGLRSCVGKEFAKILLKIFTVELARH 462
            |||..|.|||||:::|.:.||:....:.|:
  Fly   488 IPFSAGPRSCVGRKYAMLKLKVLLSTIVRN 517

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CYP26A1	NP_000774.2	p450	14..492	CDD:299894	130/543 (24%)
Cyp4g1	NP_525031.1	p450	58..518	CDD:278495	120/505 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910