DRSC/TRiP Functional Genomics Resources

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Protein Alignment USP54 and ec

DIOPT Version :10

Sequence 1:NP_001378870.1 Gene:USP54 / 159195 HGNCID:23513 Length:1706 Species:Homo sapiens
Sequence 2:NP_001096877.1 Gene:ec / 31339 FlyBaseID:FBgn0000542 Length:1765 Species:Drosophila melanogaster


Alignment Length:1619 Identity:392/1619 - (24%)
Similarity:592/1619 - (36%) Gaps:435/1619 - (26%)


- Green bases have known domain annotations that are detailed below.


Human    14 SVQGMFAPRSSTSIAPSKGLSNEPGQNSCFLNSALQVLWHLDIFRRSFRQLTTHKCMGDSCIFCA 78
            ||..:....||..:|.....|...|.::..:|||          ..|.|         |.||...
  Fly    97 SVSALAKVASSVELAVMGYNSTGNGNSNGHINSA----------GNSER---------DRCINAV 142

Human    79 LKGIFNQFQCSSEKVLPSDTLRSALAKTFQDEQRFQLGIMDDAAECFENLLMRIHFHIADETKED 143
            :: :|.|.|.|||..|..:.||.|||......:||.||.:.|||||||.||.|:|.||:.: ..|
  Fly   143 IE-LFQQLQTSSEPALCPEPLRRALASGPLAGRRFPLGCLGDAAECFELLLHRVHSHISPD-DGD 205

Human   144 ICTAQHCISHQKFAMTLFEQCVCTSCGATSDPLPFIQMVHYISTTSLWLSTGQQSGRRSGDSMSF 208
            .|.:..||:|::|||.:.||.|| .|||.|:.|||.|||||:|.::|   |.|:|          
  Fly   206 SCESSACIAHRRFAMRVIEQSVC-KCGANSEQLPFTQMVHYVSASAL---TSQKS---------- 256

Human   209 GSGDSNQAICMLERREKPSPSMFGELLQNASTMGDLRNCPSNCGERIRIRRVLMNAPQIITIGLV 273
                     ..|:..::.|   ||:||:.|..|||:|:||:.||.:|.|.|.|:|.|::::||:|
  Fly   257 ---------LALQSHQQLS---FGQLLRAAGNMGDIRDCPNTCGAKIGICRALLNRPEVVSIGIV 309

Human   274 WDSDH--SDLAEDVIHSLGTCLKLGDLFFRVTDDR-AKQSELYLVGMICYYGKHYSTFFFQTKIR 335
            |||:.  :|....|:.::||.|:|||:|.:|::.| |:|::..|||::.||||||:||||.||::
  Fly   310 WDSERPAADQVHAVLKAVGTSLRLGDVFHQVSEPRWAQQTQHELVGIVSYYGKHYTTFFFHTKLK 374

Human   336 KWMYFDDAHVKEIGPKWKDVVTKCIKGHYQPLLLLYADPQ------GTPVSTQD--LPPQAEFQS 392
            .|:|||||:|||:||.|:.||.||.:|.|||||||||.||      |..:...|  :|..|...:
  Fly   375 VWVYFDDANVKEVGPSWEGVVDKCSRGRYQPLLLLYAVPQQPTVGNGVGIGHVDVAMPASAPSIA 439

Human   393 YSRTCYDSEDSGREPSISSDTRTDSSTE-SYPYKHSHHESVVSHFSSDSQGTVIYNVENDSMSQS 456
            .|........|..:||:.:..|..:.|. ..|.....:.||:..           |:...:::..
  Fly   440 GSVVRRAVTPSPEKPSLGNTRRAITPTPLRTPPNDYQNLSVIQK-----------NIFPSNLAMG 493

Human   457 SRDTGHLTDSECNQKHTSKKGSLIERKRSSGRVRRKGDEPQASGYHSEGETLKEKQAPRNASKPS 521
            :.:|                         ...:.||..|...|..:.....:::|....|.    
  Fly   494 TDET-------------------------DAYISRKTVEHVLSAQYQNLSVIQDKIGGGNG---- 529

Human   522 SSTNRLRDFKETVSNMIHNRPSLASQTNVGSHCRGRGGDQPDKKPPRTLPLHSRDWEIESTSSES 586
                                      ..||.....:.|....:||            ||:..|..
  Fly   530 --------------------------VGVGQQSVDKDGGFLSRKP------------IEAVLSAQ 556

Human   587 KSSSSSKYRPTWRPKRESLNIDSIFSKDKRKHCGYTQLSPFSEDSAKEFIPDEPSKPPSYDIKFG 651
            .:            :|:.|.:       :|.|         |.:|:........|.|||.     
  Fly   557 LA------------RRQHLQL-------QRSH---------SAESSSGHASSNGSSPPSD----- 588

Human   652 GPSPQYKRWGPARPGSHLLEQHPRLIQRMESGYESSERNSSSPVS---LDAALPESSNVYRDPSA 713
                     |...| .||  ..||   |.:||..|.:|||:|..|   ||       |.|....|
  Fly   589 ---------GLTMP-EHL--NQPR---RRDSGNWSGDRNSASSASSTTLD-------NPYLYMVA 631

Human   714 KRSAGLVPSWRHIPKSHSSSILEVDSTASMGGWTKSQPFSGEEISSKSELDELQEEVARRAQEQE 778
            ||....||   ..|..|.   |..|              .|.:..|.|..|....:.|       
  Fly   632 KRGVAAVP---QSPTRHG---LPYD--------------PGYDSFSLSSTDSYPPKHA------- 669

Human   779 LRRKREKELEAAKGFNPHPSRFMDLDELQNQGRSDG-------FERSLQEAESVFEESLHLEQKG 836
            |..:..|..|||.|..|:..       ....|..:|       .|:...||:.:.|:|..:|:..
  Fly   670 LNPQLAKIPEAAMGVVPNGG-------AMPHGHGNGQLALSGDCEKLCHEADQLLEKSRLVEESH 727

Human   837 DCAAALALCNEAISKLRLALHGASCSTHSRALVDKKLQISIRKARSLQDRMQQQQSPQQPSQPSA 901
            |...||.|||.|..:.|.|:.....:.|:......|....:.:||||..|:..::..:..:.|..
  Fly   728 DLETALVLCNAAAGRARAAMDAPYSNPHTMTFARMKHNTCVMRARSLHRRILVEKGAETEAMPEL 792

Human   902 CLPTQAGTLSQPTSEQPIPLQVLLSQEAQLESGMDTEFGASSFFHSPASCHESH-------SSLS 959
            ....:..|.|.....|....:.|..::.||:            |.......:.|       :|:.
  Fly   793 KHMREGSTSSVKHVRQNSKDRTLEKEQQQLQ------------FQQIQQIQQIHQIQQQIPASIE 845

Human   960 PESSAPQHSSPSRSALKLLTSVEV--DNIEPSAFHRQGLPKAPGWTEKNSHHSWEPLDAPEGKLQ 1022
            ..::.|:..||    ||.|.|...  ||.......:| |..:||..|:.|...:...|..:.|..
  Fly   846 IYATLPKRKSP----LKALASASACDDNAIEYEQEKQ-LATSPGKPERESRSLFGRKDKEKEKRS 905

Human  1023 GSRCDNSSCSKLPPQEGRGI-AQEQLFQEKKDPANPSP---------------VMPGIATSERGD 1071
            .|...|....:....|...: |::.|.:.|:|......               :|.|:...:...
  Fly   906 RSEDRNKLTREFSLTETLLVNAKDTLKKHKEDKDEKKEKDKSGKKQHKIRRKLLMGGLIRRKNRS 970

Human  1072 EHSLGCSPSNSSAQPSLPLYRTCHPIMPVASSFVLHCPDPVQKTNQCLQGQSLKTSLTL---KVD 1133
            ...|..:..:|:|...:    |.||          |.|           .|.:.|:.||   .||
  Fly   971 MPDLTEAVDDSTANAGI----THHP----------HYP-----------AQGVTTAGTLLGTSVD 1010

Human  1134 RGSEETYRPEFPSTKGLVRSLAEQFQRMQGVSMRDSTGFKDRSLSGSLRKNSSPSDSKPPFSQGQ 1198
                       .|..||.:       ...|:|...|.|..|.|.|||...:.:.|:..|...:.:
  Fly  1011 -----------DSAVGLGK-------HGHGMSGYISEGHFDYSGSGSASNSGAGSNPNPNLERSK 1057

Human  1199 EKGHWPWAKQQSSLEGGDRPLSWEESTEHSSLALNSGLPNGETSSGGQPRLAEPDIYQEKLSQVR 1263
                    ..:.|..|..|.|:.....        :..|...|||     ...|...|::..|..
  Fly  1058 --------LMRKSFHGSGRQLTMVPKV--------APPPPMRTSS-----TLTPQQQQQQQQQFH 1101

Human  1264 DVRSKDLGSSTDLGTSLPLDSWVNITRFCDSQLKHGAP---------------RPGMKSSPHDSH 1313
            ...:....|:....||:..||...|...|.......:|               .|.|:..|    
  Fly  1102 HEANLSNLSAMSSNTSISEDSCQTIITTCAQVHSEQSPLKDLQMLVAQDELPLPPPMELPP---- 1162

Human  1314 TCVTYPERNHILLH-----------PHWNQDTE---QETSELESLYQASLQASQAGCSGWGQQDT 1364
                ||...|...|           |....|.|   |:.|:|::|..||.|..|           
  Fly  1163 ----YPSPPHSSCHSRQASEDFPPPPPPELDLEPLNQQLSQLQALEAASKQQRQ----------- 1212

Human  1365 AWHPLSQTGSADG-------MGRRLH-------SAHDPGLSKTSTAEMEHGLHEARTVRTSQATP 1415
                  |..|.:|       :.:|.|       .|:.||.:.|....:       :.::..||..
  Fly  1213 ------QLESLEGTTSILAQLQQRQHLLKLRKEQANHPGAATTDATWL-------KELQAKQAND 1264

Human  1416 CRGLSRECGEDEQYSAENLRRISRSLSGTVVSEREEAPVSSHSFDSSNV------RKPLETGHR- 1473
            .|.:.|:.   |..|..::|.::.....|.:.......:.|....|..:      ...|..|:. 
  Fly  1265 LRAMQRKL---EASSPSSVRDLTHRFEQTSIRSYASQELLSQPGQSQQLGQLRTQMNGLPNGNAK 1326

Human  1474 --CSSSSSLPVIHDPSVFLLGPQLYLPQPQFLSPDVLMPTMAGEPNRLPGTSRSVQQFL 1530
              .....::|.:.:.....|.....||:|::   ::....:|.|...:...:..|||.|
  Fly  1327 MDVDEVDAMPAVRNSLPAALSAHQLLPKPKY---EMTQSQIAEEIREVELLNTMVQQTL 1382

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
USP54NP_001378870.1 Peptidase_C19 32..371 CDD:470612 146/341 (43%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 396..438 8/42 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 452..600 15/147 (10%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 629..725 29/98 (30%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 742..764 3/21 (14%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 881..916 7/34 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 950..972 5/28 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 989..1082 18/108 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1161..1249 19/87 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1356..1413 9/70 (13%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1447..1477 4/38 (11%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1642..1674
ecNP_001096877.1 Peptidase_C19 <183..390 CDD:470612 107/233 (46%)
C1 <1736..>1758 CDD:412127
Blue background indicates that the domain is not in the aligned region.

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