Protein Alignment CYP24A1 and Cyp6a22

DIOPT Version :10

• Sequence 1: NP_000773.2
• Gene: CYP24A1 / 1591
• HGNCID: 2602
• Length: 514
• Species: Homo sapiens
• Sequence 2: NP_652075.1
• Gene: Cyp6a22 / 49847
• FlyBaseID: FBgn0013773
• Length: 499
• Species: Drosophila melanogaster
• Alignment Length: 491
• Identity: 117/491 - (23%)
• Similarity: 216/491 - (43%)
• Gaps: 93/491 - (18%)

Human    61 PTSWPLLGSLLQILWKGGLKKQH--DTLVEYHKKY---GKIFRMKLGSFESVHLGSPCLLEALYR 120
            |..:| :|::     :|..|.:|  |.:...::|:   |..|   .|.|..:.   |.:|.
  Fly    35 PARFP-VGNM-----EGFRKNKHFIDIVTPIYEKFKGNGAPF---AGFFMMLR---PVVLV---- 83

Human   121 TESAYPQRLEIKPWKAYRD---YRKE------GYGLLILEGEDWQRVR-------SAFQKKLMKP 169
            |:....:::.|:.:..:.|   |..|      |: |..::|..|:.:|       ::.:.|.|.|
  Fly    84 TDLELAKQILIQDFANFEDRGMYHNERDDPLTGH-LFRIDGPKWRPLRQKMSPTFTSAKMKYMFP 147

Human   170 GEVMKLDNKINEV---LADFMGRIDELCD--ERGHVEDLYSE--LNKWSFESICLVLY--EKRFG 225
             .|.::..::.:|   |||     :.:|.  |.|.:...|:.  :.:.:|...|..|.  |..|.
  Fly   148 -TVCEVGEELTQVCGELAD-----NAMCGILEIGDLMARYTSDVIGRCAFGVECNGLRNPEAEFA 206

Human   226 LLQKNAGDE------AVNFIMAIKTMMSTFGRMMVTPVELHKSLNTKVWQDHTLAWDTIFKSVKA 284
            ::.:.|..|      ...||.:... ::.|.||.    ::|        ||.|   |.....|:.
  Fly   207 IMGRRAFSERRHCKLVDGFIESFPE-VARFLRMR----QIH--------QDIT---DFYVGIVRE 255

Human   285 CIDNRLEKYSQQPSADF---LCDIYHQNRLSKKELYAAVTELQLAAVETTANSLMWILYNLSRNP 346
            .:..|.|:...:  :||   |.::..:..|:.:|:.|.......|..:|:|::|.:.||.|::.|
  Fly   256 TVKQREEQGIVR--SDFMNLLIEMKQRGELTIEEMAAQAFIFFAAGFDTSASTLGFALYELAKQP 318

Human   347 QVQQKLLKEI-QSVLPENQVPRAEDLRNMPYLKACLKESMRLTPSVPFTTRT---LDKATVLGEY 407
            .:|.||.:|| |::...|.....:.::.:.|::..:.|::|..|.:|..||.   |..|.....:
  Fly   319 ALQAKLREEIDQALRLHNGEFTYDSMQELRYMELVIAETLRKYPILPQLTRISRHLYAAKGDRHF 383

Human   408 ALPKGTVLMLNTQVLGSSEDN--FEDSSQFRPERWLQEKEKINP-FAHLPFGVGKRMCIGRRLAE 469
            .:..|.:|::  .|.|...|.  :.:..:|.|||:|.::....| .|.||||.|.|.|||.|..:
  Fly   384 YIEPGQMLLI--PVYGIHHDPALYPEPHKFIPERFLADQLAQRPTAAWLPFGDGPRNCIGMRFGK 446

Human   470 LQLHLALCWIVRKYDIQA---TDNEPVEMLHSGTLV 502
            :|..:.|..::|.:....   ||.: :|.|.|..|:
  Fly   447 MQTTIGLVSLLRNFHFSVCPRTDPK-IEFLKSNILL 481

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CYP24A1	NP_000773.2	CYP24A1	90..508	CDD:410738	110/460 (24%)
Cyp6a22	NP_652075.1	CYP6-like	66..488	CDD:410679	109/454 (24%)