Protein Alignment CYP24A1 and Cyp4d14

DIOPT Version :10

• Sequence 1: NP_000773.2
• Gene: CYP24A1 / 1591
• HGNCID: 2602
• Length: 514
• Species: Homo sapiens
• Sequence 2: NP_001259179.1
• Gene: Cyp4d14 / 45706
• FlyBaseID: FBgn0023541
• Length: 510
• Species: Drosophila melanogaster
• Alignment Length: 502
• Identity: 112/502 - (22%)
• Similarity: 211/502 - (42%)
• Gaps: 100/502 - (19%)

Human    56 AALPGPTSWPLLGSLLQILWKGGLKKQ--HDTLVEYHKKYGKIFRMKLGSFESVHLGSPCLLEAL 118
            |.:.||.|:||:|:...::.:....|.  .|.......::||..:.::............::||:
  Fly    31 AGIRGPKSYPLVGNAPLLINESPKSKSSIFDMQFRLIAEFGKNIKTQMLGESGFMTADSKMIEAI 95

Human   119 YRTESAYPQRLE-------IKPWKAYRDYRKEGYGLLILEGEDWQRVRSAFQKKLMKPGEVMKLD 176
            ..::    |.::       :..|.        |.||||.:|:.|.|     ::|::.|....|
  Fly    96 MSSQ----QTIQKNNLYSLLVNWL--------GDGLLISQGKKWFR-----RRKIITPAFHFK-- 141

Human   177 NKINEVLADFMGRIDELCDERG--HVEDLYSE------LNKWSFESICL--VLYEKRFGLLQKNA 231
                 :|.||:    |:.|::.  .|:.||..      :|.:....:|.  ::.|...|:.....
  Fly   142 -----ILEDFV----EVFDQQSATMVQKLYDRADGKTVINMFPVACLCAMDIIAETAMGVKINAQ 197

Human   232 GDEAVNFIMAIKTMMSTFGRMMVTPVE------------LHKSLNTKVWQDHTLAWDTIFKSVKA 284
            ......::.::.|..:......:.|::            |...||..|...|..        ..:
  Fly   198 LQPQFTYVQSVTTASAMLAERFMNPLQRLDFTMKLFYPKLLDKLNDAVKNMHDF--------TNS 254

Human   285 CIDNRLEKYSQQPSAD-------FLCDIYHQNR----------------LSKKELYAAVTELQLA 326
            .|..|.| ..|:..||       .|.|:..:.|                ||..::...|......
  Fly   255 VITERRE-LLQKAIADGGDADAALLNDVGQKRRMALLDVLLKSTIDGAPLSNDDIREEVDTFMFE 318

Human   327 AVETTANSLMWILYNLSRNPQVQQKLLKEIQSVLPENQ-VP-RAEDLRNMPYLKACLKESMRLTP 389
            ..:||.:|:.:..|.|:|:|:||.::.:|::.|:.::: .| ..:.|..:.||:..:|||:||.|
  Fly   319 GHDTTTSSIAFTCYLLARHPEVQARVFQEVRDVIGDDKSAPVTMKLLGELKYLECVIKESLRLFP 383

Human   390 SVPFTTRTLDKATVLGEYALPKGT---VLMLNTQVLGSSEDNFEDSSQFRPERW-LQEKEKINPF 450
            |||...|.:.:.|||....:|..:   :|:.:.|   ...|.|.|..:|.|:|: ::.|.:|:||
  Fly   384 SVPIIGRYISQDTVLDGKLIPADSNVIILIYHAQ---RDPDYFPDPEKFIPDRFSMERKGEISPF 445

Human   451 AHLPFGVGKRMCIGRRLAELQLHLALCWIVRKYDIQATDNEPVEMLH 497
            |:.||..|.|.|||::.|.|::...:..:||.:::.....|...:|:
  Fly   446 AYTPFSAGPRNCIGQKFAMLEMKSTISKMVRHFELLPLGEEVQPVLN 492

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CYP24A1	NP_000773.2	CYP24A1	90..508	CDD:410738	103/466 (22%)
Cyp4d14	NP_001259179.1	CYP4	71..503	CDD:410721	103/462 (22%)