Protein Alignment CYP24A1 and Cyp4c3

DIOPT Version :10

• Sequence 1: NP_000773.2
• Gene: CYP24A1 / 1591
• HGNCID: 2602
• Length: 514
• Species: Homo sapiens
• Sequence 2: NP_524598.1
• Gene: Cyp4c3 / 43663
• FlyBaseID: FBgn0015032
• Length: 535
• Species: Drosophila melanogaster
• Alignment Length: 509
• Identity: 122/509 - (23%)
• Similarity: 218/509 - (42%)
• Gaps: 84/509 - (16%)

Human    58 LPGPTSWPLLGSLLQILWKGGLKKQHDTL----VEYHKKYGK---IFRMKLGSFESVHLGSPCLL 115
            :|||.:.|.||:.::      :...||.|    :...|.:|.   |.|:..|:...|.|..|..:
  Fly    58 IPGPAAMPFLGNAIE------MNVDHDELFNRVIGMQKLWGTRIGINRVWQGTAPRVLLFEPETV 116

Human   116 EALYRTESAYPQRLE---IKPWKAYRDYRKEGYGLLILEGEDWQRVRSAFQKKLMKPGEVMKLDN 177
            |.:..::....:..:   :.||.        |.|||......|..     ::|::.|....|
  Fly   117 EPILNSQKFVNKSHDYDYLHPWL--------GEGLLTSTDRKWHS-----RRKILTPAFHFK--- 165

Human   178 KINEVLADFMGRIDE--------LCDERG-HVEDLYSELNKWSFESICLVLYEKRFGLLQKNAGD 233
                :|.||:...:|        |..|.| ...:|:..:...:.:.:|.....:|. ..|.|:..
  Fly   166 ----ILDDFIDVFNEQSAVLARKLAVEVGSEAFNLFPYVTLCTLDIVCETAMGRRI-YAQSNSES 225

Human   234 EAVNFIMAIKT----------MMSTFGRMMVTPVELHKS-LNTKVWQDHTLAWDTIFKSVKACI- 286
            |.|..:..|.:          :.|.|...:....:||:| :||.    |..: :.:.:..||.:
  Fly   226 EYVKAVYGIGSIVQSRQAKIWLQSDFIFSLTAEYKLHQSYINTL----HGFS-NMVIRERKAELA 285

Human   287 ---DNRLEKYSQQPSA-------------DFLCDIYHQNR-LSKKELYAAVTELQLAAVETTANS 334
               :|.....:..|.|             |.|.|...:.. ||.:::...|........:||:.:
  Fly   286 ILQENNNNNNNNAPDAYDDVGKKKRLAFLDLLIDASKEGTVLSNEDIREEVDTFMFEGHDTTSAA 350

Human   335 LMWILYNLSRNPQVQQKLLKEIQSVLPENQVPRA--EDLRNMPYLKACLKESMRLTPSVPFTTRT 397
            :.|.|:.|..:|:.|:::::|:.|:..:::...|  ::|.:|.||:.|:|:|:||.||||...|.
  Fly   351 ISWTLFLLGCHPEYQERVVEELDSIFGDDKETPATMKNLMDMRYLECCIKDSLRLFPSVPMMARM 415

Human   398 LDKATVLGEYALPKGTVLMLNTQVLGSSEDNFEDSSQFRPERWLQEK-EKINPFAHLPFGVGKRM 461
            :.:...:|...:|.||..::.|..|..:...|....||.|:.:|.|. ...:|||::||..|.|.
  Fly   416 VGEDVNIGGKIVPAGTQAIIMTYALHRNPRVFPKPEQFNPDNFLPENCAGRHPFAYIPFSAGPRN 480

Human   462 CIGRRLAELQLHLALCWIVRKYDIQATD-NEPVEMLHSGTLVPSRELPIAFCQR 514
            |||::.|.|:....:..::|||.|:|.| .|.:.:|....|.|...|.:....|
  Fly   481 CIGQKFAILEEKAVISTVLRKYKIEAVDRREDLTLLGELILRPKDGLRVKITPR 534

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CYP24A1	NP_000773.2	CYP24A1	90..508	CDD:410738	111/465 (24%)
Cyp4c3	NP_524598.1	CYP4V-like	96..529	CDD:410753	110/458 (24%)