Protein Alignment CYP24A1 and Cyp6d4

DIOPT Version :10

• Sequence 1: NP_000773.2
• Gene: CYP24A1 / 1591
• HGNCID: 2602
• Length: 514
• Species: Homo sapiens
• Sequence 2: NP_651082.1
• Gene: Cyp6d4 / 42682
• FlyBaseID: FBgn0039006
• Length: 515
• Species: Drosophila melanogaster
• Alignment Length: 453
• Identity: 97/453 - (21%)
• Similarity: 195/453 - (43%)
• Gaps: 93/453 - (20%)

Human    96 IFRMKLGSFESV-HLGSPCL----LEALYRTES-------AYPQRLEIKPWKAYR--DYRK--EG 144
            ||.::..|:.|: |:.|||.    |::::.|..       |:.|: |: |.:.::  |.:|  :.
  Fly   117 IFSLRGQSWRSMRHMLSPCFTSGKLKSMFSTSEDIGDKMVAHLQK-EL-PEEGFKEVDIKKVMQN 179

Human   145 YGLLILEGEDWQRVRSAFQ---KKLMKPGEVMKLDNKINEV----------LADFMGRIDELCDE 196
            |.:.|:....:....::|:   .|..|...:.:.:|:.|.:          :|.|:.||    ..
  Fly   180 YAIDIIASTIFGLDVNSFENPDNKFRKLVSLARANNRFNAMFGMMIFLVPSIAQFLFRI----GF 240

Human   197 RGHVEDLYSELNKWSFESICLVLYEKRFGLLQKNAGDEAVNFIMAIKTMMSTFGRMMVTPVELHK 261
            :..|.....::.|.:.|      |.::.|:::|:        ::.:...:...|:
  Fly   241 KNPVGLAMLQIVKETVE------YREKHGIVRKD--------LLQLLIQLRNTGK---------- 281

Human   262 SLNTKVWQDHTLAWDTIFKSVKACIDNRLEK-YSQQPSADFLCDIYHQNRLSKKELYAAVTELQL 325
                                    ||...|| :|.|.:.|     .|...:|.:.:.|......:
  Fly   282 ------------------------IDENDEKSFSIQKTPD-----GHIKTISLEAITAQAFIFYI 317

Human   326 AAVETTANSLMWILYNLSRNPQVQQKLLKEIQSVLPENQVPRAED-LRNMPYLKACLKESMRLTP 389
            |..|||.::..:.:|.|::.|::.::|..|:...|.:|......| |..|.:|..|::|::|..|
  Fly   318 AGQETTGSTAAFTIYELAQYPELLKRLQDEVDETLAKNDGKITYDSLNKMEFLDLCVQETIRKYP 382

Human   390 SVPFTTR--TLDKATVLGEYALPKGTVLMLNTQVLGSSEDNFEDSSQFRPERWLQEKEKINPFAH 452
            .:|...|  |.|.......:.:||||.::::...:....:.|.|...:.|||:.:|....||.|.
  Fly   383 GLPILNRECTQDYTVPDTNHVIPKGTPVVISLYGIHHDAEYFPDPETYDPERFSEESRNYNPTAF 447

Human   453 LPFGVGKRMCIGRRLAELQLHLALCWIVRKYDIQATDNEPVEMLHSG-TLVPSRELPIAFCQR 514
            :|||.|.|:||.:|:..:...||:..|::.::::......:|..:|| .|:|...:.:...:|
  Fly   448 MPFGEGPRICIAQRMGRINSKLAIIKILQNFNVEVMSRSEIEFENSGIALIPKHGVRVRLSKR 510

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CYP24A1	NP_000773.2	CYP24A1	90..508	CDD:410738	96/445 (22%)
Cyp6d4	NP_651082.1	CYP6-like	66..504	CDD:410679	96/445 (22%)