Protein Alignment CYP24A1 and Cyp12a4

DIOPT Version :10

• Sequence 1: NP_000773.2
• Gene: CYP24A1 / 1591
• HGNCID: 2602
• Length: 514
• Species: Homo sapiens
• Sequence 2: NP_650783.2
• Gene: Cyp12a4 / 42294
• FlyBaseID: FBgn0038681
• Length: 536
• Species: Drosophila melanogaster
• Alignment Length: 500
• Identity: 142/500 - (28%)
• Similarity: 240/500 - (48%)
• Gaps: 66/500 - (13%)

Human    58 LPGPTSWPLLGSLLQILWKGGLKKQHDTLVEY---HKKYGKIFRMK--LGS--FESVHLGSPCLL 115
            :|....|.|   .:::...||..|..:.:..:   .:.||.||.|.  :|:  |.|.|  :|...
  Fly    50 IPRLNMWAL---SMKMSMPGGKYKNMELMEMFEAMRQDYGDIFFMPGIMGNPPFLSTH--NPQDF 109

Human   116 EALYRTESAYPQRLEIKPWKAYR-DYRKEGY----GLLILEGEDWQRVRSAFQKKLMKPGEVMKL 175
            |.::|.|..:|.|........:| :|||:.|    |::..:|:.|...|:.....||:|..|...
  Fly   110 EVVFRNEGVWPNRPGNYTLLYHREEYRKDFYQGVMGVIPTQGKPWGDFRTVVNPVLMQPKNVRLY 174

Human   176 DNKINEVLADFMGRIDEL--CDERGHVEDLYSELNKWSFESICLVLYEKRFGLLQ-KNAGDEAVN 237
            ..|:::|..:|:.||.||  .|.....:|....:|:|:.||:.:|..:|:.|||: .|...||:.
  Fly   175 YKKMSQVNQEFVQRILELRDPDTLEAPDDFIDTINRWTLESVSVVALDKQLGLLKNSNKESEALK 239

Human   238 --------FIMAIK-TMMSTFGRMMVTPVELHKSLNTKVWQDHTLAWDTIFKSVKACIDNRLEKY 293
                    ||::|. .|..:..|.:.|| :|.:.:.         |.|.|.:...|.:|..:|:.
  Fly   240 LFHYLDEFFIVSIDLEMKPSPWRYIKTP-KLKRLMR---------ALDGIQEVTLAYVDEAIERL 294

Human   294 SQQPSADFLCDIYHQNRLSK------KELYAAVTELQLAAVETTANSLMWILYNLSRNPQVQQKL 352
            .::.....:.....|:.|.|      |.......::.:|.|:||:::...:|..|::||:.|.:|
  Fly   295 DKEAKEGVVRPENEQSVLEKLLKVDRKVATVMAMDMLMAGVDTTSSTFTALLLCLAKNPEKQARL 359

Human   353 LKEIQSVLPENQVPRAE-DLRNMPYLKACLKESMRLTPSVPFTTRTLDKATVLGEYALPKGT--- 413
            .:|:..|||.......| .::|:|||:||:|||.||.|.:....|.|.:..||..|.:|.||
  Fly   360 REEVMKVLPNKNSEFTEASMKNVPYLRACIKESQRLHPLIVGNARVLARDAVLSGYRVPAGTYVN 424

Human   414 VLMLNTQVLGSSEDNFEDSSQFRPERWLQ------------EKEKINPFAHLPFGVGKRMCIGRR 466
            ::.||..   :.::.|..:|:|.|||||:            |.:..|||..||||.|.|||:|:|
  Fly   425 IVPLNAL---TRDEYFPQASEFLPERWLRSPKDSESKCPANELKSTNPFVFLPFGFGPRMCVGKR 486

Human   467 LAELQLHLALCWIVRKYDIQATDNEPVEMLHSGTLVPSRELPIAF 511
            :.|::|.|....::|.::::.  |.|.|......|:....:|:.|
  Fly   487 IVEMELELGTARLIRNFNVEF--NYPTENAFRSALINLPNIPLKF 529

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CYP24A1	NP_000773.2	CYP24A1	90..508	CDD:410738	134/460 (29%)
Cyp12a4	NP_650783.2	CYP24A1-like	82..528	CDD:410677	135/462 (29%)