Protein Alignment CYP24A1 and Cyp12a5

DIOPT Version :10

• Sequence 1: NP_000773.2
• Gene: CYP24A1 / 1591
• HGNCID: 2602
• Length: 514
• Species: Homo sapiens
• Sequence 2: NP_650782.1
• Gene: Cyp12a5 / 42293
• FlyBaseID: FBgn0038680
• Length: 536
• Species: Drosophila melanogaster
• Alignment Length: 459
• Identity: 126/459 - (27%)
• Similarity: 219/459 - (47%)
• Gaps: 54/459 - (11%)

Human    93 YGKIFRM--KLGSFESVHLGSPCLLEALYRTESAYPQRLEIKPWKAYRD-YRKEGY----GLLIL 150
            ||.|..:  .:|....|...:|...|.::|.|..:|.|......:.:|. |||:.:    |::..
  Fly    85 YGNIIFLPGMMGRDGLVMTHNPKDFEVVFRNEGVWPFRPGSDILRYHRTVYRKDFFDGVQGIIPS 149

Human   151 EGEDWQRVRSAFQKKLMKPGEVMKLDNKINEVLADFMGRIDELCD-ERGHVEDLYSE-LNKWSFE 213
            :|:.|...||.....||:|..|.....|:::|..:|:..|.|:.| ....|...:.| :|:|:.|
  Fly   150 QGKSWGDFRSIVNPVLMQPKNVRLYFKKMSQVNQEFVELIKEIRDASTQEVPGNFLETINRWTLE 214

Human   214 SICLVLYEKRFGLLQKNA-GDEAVNFI---------MAIKTMMSTFGRMMVTPVELHKSLNTKVW 268
            |:.:|..:|:.|||:::. ..||....         .|...|..:..|...||: |.|.|.|
  Fly   215 SVSVVALDKQLGLLRESGKNSEATKLFKYLDEFFLHSADLEMKPSLWRYFKTPL-LKKMLRT--- 275

Human   269 QDHTLAWDTIFKSVKACIDNRLEKYSQQPSADFLCDIYHQN------RLSKKELYAAVTELQLAA 327
                  .|::.:.....:|..:|:..::.....:...:.|:      ::.||.......::.:|.
  Fly   276 ------MDSVQEVTLKYVDEAIERLEKEAKEGVVRPEHEQSVLEKLLKVDKKVATVMAMDMLMAG 334

Human   328 VETTANSLMWILYNLSRNPQVQQKLLKEIQSVLPENQVPRAE-DLRNMPYLKACLKESMRLTPSV 391
            |:||:::...:|..|::||:.|.:|.:|:..|||.......| .::|:|||:||:|||.|:.|.|
  Fly   335 VDTTSSTFTALLLCLAKNPEKQARLREEVMKVLPNKDSEFTEASMKNVPYLRACIKESQRVYPLV 399

Human   392 PFTTRTLDKATVLGEYALPKGTVL-MLNTQVLGSSEDNFEDSSQFRPERWLQE------------ 443
            ....|.|.:.:|:..|.:|.||:: |:....| .||:.|...::|.|||||:.
  Fly   400 IGNARGLTRDSVISGYRVPAGTIVSMIPINSL-YSEEYFPKPTEFLPERWLRNASDSAGKCPAND 463

Human   444 -KEKINPFAHLPFGVGKRMCIGRRLAELQLHLALCWIVRKYDIQATDNEPVEMLHSGTLVPSREL 507
             |.| |||..||||.|.|||:|:|:.|::|.|....::|.::::.  |...:......|:....:
  Fly   464 LKTK-NPFVFLPFGFGPRMCVGKRIVEMELELGTARLIRNFNVEF--NHSTKNAFRSALINLPNI 525

Human   508 PIAF 511
            |:.|
  Fly   526 PLKF 529

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CYP24A1	NP_000773.2	CYP24A1	90..508	CDD:410738	124/454 (27%)
Cyp12a5	NP_650782.1	CYP24A1-like	82..528	CDD:410677	125/456 (27%)