DRSC/TRiP Functional Genomics Resources

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Protein Alignment CYP24A1 and Cyp12a5

DIOPT Version :9

Sequence 1:NP_000773.2 Gene:CYP24A1 / 1591 HGNCID:2602 Length:514 Species:Homo sapiens
Sequence 2:NP_650782.1 Gene:Cyp12a5 / 42293 FlyBaseID:FBgn0038680 Length:536 Species:Drosophila melanogaster


Alignment Length:459 Identity:126/459 - (27%)
Similarity:219/459 - (47%) Gaps:54/459 - (11%)


- Green bases have known domain annotations that are detailed below.


Human    93 YGKIFRM--KLGSFESVHLGSPCLLEALYRTESAYPQRLEIKPWKAYRD-YRKEGY----GLLIL 150
            ||.|..:  .:|....|...:|...|.::|.|..:|.|......:.:|. |||:.:    |::..
  Fly    85 YGNIIFLPGMMGRDGLVMTHNPKDFEVVFRNEGVWPFRPGSDILRYHRTVYRKDFFDGVQGIIPS 149

Human   151 EGEDWQRVRSAFQKKLMKPGEVMKLDNKINEVLADFMGRIDELCD-ERGHVEDLYSE-LNKWSFE 213
            :|:.|...||.....||:|..|.....|:::|..:|:..|.|:.| ....|...:.| :|:|:.|
  Fly   150 QGKSWGDFRSIVNPVLMQPKNVRLYFKKMSQVNQEFVELIKEIRDASTQEVPGNFLETINRWTLE 214

Human   214 SICLVLYEKRFGLLQKNA-GDEAVNFI---------MAIKTMMSTFGRMMVTPVELHKSLNTKVW 268
            |:.:|..:|:.|||:::. ..||....         .|...|..:..|...||: |.|.|.|   
  Fly   215 SVSVVALDKQLGLLRESGKNSEATKLFKYLDEFFLHSADLEMKPSLWRYFKTPL-LKKMLRT--- 275

Human   269 QDHTLAWDTIFKSVKACIDNRLEKYSQQPSADFLCDIYHQN------RLSKKELYAAVTELQLAA 327
                  .|::.:.....:|..:|:..::.....:...:.|:      ::.||.......::.:|.
  Fly   276 ------MDSVQEVTLKYVDEAIERLEKEAKEGVVRPEHEQSVLEKLLKVDKKVATVMAMDMLMAG 334

Human   328 VETTANSLMWILYNLSRNPQVQQKLLKEIQSVLPENQVPRAE-DLRNMPYLKACLKESMRLTPSV 391
            |:||:::...:|..|::||:.|.:|.:|:..|||.......| .::|:|||:||:|||.|:.|.|
  Fly   335 VDTTSSTFTALLLCLAKNPEKQARLREEVMKVLPNKDSEFTEASMKNVPYLRACIKESQRVYPLV 399

Human   392 PFTTRTLDKATVLGEYALPKGTVL-MLNTQVLGSSEDNFEDSSQFRPERWLQE------------ 443
            ....|.|.:.:|:..|.:|.||:: |:....| .||:.|...::|.|||||:.            
  Fly   400 IGNARGLTRDSVISGYRVPAGTIVSMIPINSL-YSEEYFPKPTEFLPERWLRNASDSAGKCPAND 463

Human   444 -KEKINPFAHLPFGVGKRMCIGRRLAELQLHLALCWIVRKYDIQATDNEPVEMLHSGTLVPSREL 507
             |.| |||..||||.|.|||:|:|:.|::|.|....::|.::::.  |...:......|:....:
  Fly   464 LKTK-NPFVFLPFGFGPRMCVGKRIVEMELELGTARLIRNFNVEF--NHSTKNAFRSALINLPNI 525

Human   508 PIAF 511
            |:.|
  Fly   526 PLKF 529

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CYP24A1NP_000773.2 p450 59..512 CDD:278495 126/459 (27%)
Cyp12a5NP_650782.1 p450 81..531 CDD:278495 126/459 (27%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 194 1.000 Domainoid score I3171
eggNOG 1 0.900 - - E2759_KOG0159
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 201 1.000 Inparanoid score I3768
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D185685at33208
OrthoFinder 1 1.000 - - FOG0000720
OrthoInspector 1 1.000 - - mtm8467
orthoMCL 1 0.900 - - OOG6_100895
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X156
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
98.770

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