Protein Alignment CYP24A1 and Cyp12e1

DIOPT Version :10

• Sequence 1: NP_000773.2
• Gene: CYP24A1 / 1591
• HGNCID: 2602
• Length: 514
• Species: Homo sapiens
• Sequence 2: NP_650003.4
• Gene: Cyp12e1 / 41272
• FlyBaseID: FBgn0037817
• Length: 522
• Species: Drosophila melanogaster
• Alignment Length: 504
• Identity: 143/504 - (28%)
• Similarity: 234/504 - (46%)
• Gaps: 65/504 - (12%)

Human    51 ETQNAAALPGPTSWPLLGSLLQILWKGGLKKQ---HDTLVEYHKKYGKIFRM-KLGSFESVHLGS 111
            |.:..|.:|||:...|:.:.|    .|||.|.   |:..::.:::||.|||| .:...:.|...:
  Fly    34 EAKPYADIPGPSKLQLIRAFL----PGGLYKNLPVHEMFLDMNRQYGSIFRMPSVAGTDLVLTMN 94

Human   112 PCLLEALYRTESAYPQRLEIKPWKAY-RDYRKE---GY-GLLILEGEDWQRVRSAFQKKLMKPGE 171
            |...|.::|.|..||.|...:....: |.:|:|   || ||....|..|.::|:|....|::|..
  Fly    95 PQDYEVIFRNEGQYPYRRSFEVMDYFKRVHRREVFDGYDGLTSGNGPAWGKMRTAVNPILLQPRN 159

Human   172 VMKLDNKINEVLADFMGRI----DELCDERGHVEDLYSELNKWSFESICLVLYEKRFGLL--QKN 230
            .......:.:|..:|:.||    |.:..|.  .:|...::.....||||.|......|||  |:|
  Fly   160 AKLYMTNLVQVSDEFLERIRIIRDPVTQEM--PDDFAVDIRHLVIESICSVALNTHLGLLGEQRN 222

Human   231 AGDEAVNFIMAIK---------TMMSTFGRMMVTP--VELHKSLNTKVWQDHTLAWDTIFKSVKA 284
            ..| ....::|::         .:|..|.:.:..|  .:|.:||            |||......
  Fly   223 NKD-IQKLVLALQDVVELGFQLDIMPAFWKYLPMPNFKKLMRSL------------DTITDFCYF 274

Human   285 CIDNRLEKYSQQPSADFLCDIYHQNRLSKK----ELYAAV---TELQLAAVETTANSLMWILYNL 342
            .|.|.|::..:...|..|.:|..:..|.:|    :...||   .:|..|..:.|..:|..||::|
  Fly   275 HIGNALKRIEEDAKAGTLNEIGLETSLLEKLARFDRQTAVIIAMDLLFAGADPTLVTLGGILFSL 339

Human   343 SRNPQVQQKLLKEIQSVLP-ENQVPRAEDLRNMPYLKACLKESMRLTPSVPFTTRTLDKATVLGE 406
            |::|..|.:||:||:.:|| ::.....|::||:|||:||:||.:|:.|..|.|.|.:....||..
  Fly   340 SKSPDKQARLLEEIRGILPNKDSSLTIENMRNLPYLRACIKEGIRMYPIGPGTLRRMPHDVVLSG 404

Human   407 YALPKGT--VLMLNTQVLGSSEDNFEDSSQFRPERWLQEK-------EKINPFAHLPFGVGKRMC 462
            |.:..||  .:..|.| :.:.|.......:|.|||||:::       |...||.:||||.|.|.|
  Fly   405 YRVVAGTDVGIAANYQ-MANMEQFVPKVREFIPERWLRDESNSHLVGETATPFMYLPFGFGPRSC 468

Human   463 IGRRLAELQLHLALCWIVRKYDIQATDNEPVEMLHSGTLVPSRELPIAF 511
            .|:|:.::.|.:|:..:||.:.|..  :.|:|............:|..|
  Fly   469 AGKRIVDMMLEIAISRLVRNFKIGF--DYPIENAFKAQFFVQPNIPFKF 515

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CYP24A1	NP_000773.2	CYP24A1	90..508	CDD:410738	129/457 (28%)
Cyp12e1	NP_650003.4	CYP24A1-like	73..514	CDD:410677	130/458 (28%)