Protein Alignment CYP24A1 and Cyp12c1

DIOPT Version :9

• Sequence 1: NP_000773.2
• Gene: CYP24A1 / 1591
• HGNCID: 2602
• Length: 514
• Species: Homo sapiens
• Sequence 2: NP_001287109.1
• Gene: Cyp12c1 / 40037
• FlyBaseID: FBgn0036806
• Length: 524
• Species: Drosophila melanogaster
• Alignment Length: 551
• Identity: 150/551 - (27%)
• Similarity: 252/551 - (45%)
• Gaps: 87/551 - (15%)

Human     2 SSPISKSRS--LAAFLQQLRSPRQPPRLVTSTAYTSPQPREVPVCPLTAGGETQNAAALPGPTSW 64
            :|.::.:|:  .::::|||.|..:..:                  |.|         .|||||.|
  Fly    13 NSQLAATRNPDASSYVQQLESEWEGAK------------------PFT---------ELPGPTRW 50

Human    65 PLLGSLLQILWKGGLKKQ---HDTLVEYHKKYGKI-------------FRMKLGSFESVHLGSPC 113
                .|.:...|||...|   .|.:..|.|::|.|             |...:.:||.|
  Fly    51 ----QLFRGFQKGGEYHQLGMDDVMRLYKKQFGDICLIPGLFGMPSTVFTFNVETFEKV------ 105

Human   114 LLEALYRTESAYPQRLEIKPWKAYRDYRKEGY-----GLLILEGEDWQRVRSAFQKKLMKPGEVM 173
                 ||||..:|.|...:|...||:.||:.:     | |...|.:|.:.|||....||:...|.
  Fly   106 -----YRTEGQWPVRGGAEPVIHYRNKRKDEFFKNCMG-LFGNGAEWGKNRSAVNPVLMQHRNVA 164

Human   174 KLDNKINEVLADFMGRIDELCDERGH--VEDLYSELNKWSFESICLVLYEKRFGLLQK-NAGDEA 235
            .....:..|...|:.||.|:.|:...  ..|..:.:|..:|||:..|..::..|||:: |...||
  Fly   165 IYLKPMQRVNRQFVNRIREIRDKESQEVPGDFMNTINHLTFESVATVALDRELGLLREANPPPEA 229

Human   236 VNFIMAIKTMMSTFGRMMVTPVELHKSLNTKVWQDHTLAWDTIFKSVKACIDNRLE----KYSQQ 296
            ......|:.:|.:|..:.|.| .|::.:.|..::..:.|.|.||.:....::..:|    |.||.
  Fly   230 SKLFKNIEVLMDSFFDLGVRP-SLYRYIPTPTYKKFSRAMDEIFDTCSMYVNQAIERIDRKSSQG 293

Human   297 PSADFLCDIYHQNRLSKKELYAAVTELQLAAVETTANSLMWILYNLSRNPQVQQKLLKEIQSVLP 361
            .|.|....:....::.:|.......::.:..|:||:.::..||.||::||:.||:|.:|:.|.|.
  Fly   294 DSNDHKSVLEQLLQIDRKLAVVMAMDMLMGGVDTTSTAISGILLNLAKNPEKQQRLREEVLSKLT 358

Human   362 E-NQVPRAEDLRNMPYLKACLKESMRLTPSVPFTTRTLDKATVLGEYALPKGTVLMLNTQVLGSS 425
            . :.....||::::|||:|.:|||:||.|......|:.....||..|.:||||.|::....|...
  Fly   359 SLHSEFTVEDMKSLPYLRAVIKESLRLYPVTFGNARSAGADVVLDGYRIPKGTKLLMTNSFLLKD 423

Human   426 EDNFEDSSQFRPERWLQEKE----------KINPFAHLPFGVGKRMCIGRRLAELQLHLALCWIV 480
            :..:..:.:|.|||||:.|:          .:|.|.:||||.|.|||:|:|:.:|::.|.:..:|
  Fly   424 DRLYPRAKEFIPERWLRRKDDDKSDVLMNKDLNAFIYLPFGFGPRMCVGKRIVDLEMELTVANLV 488

Human   481 RKYDIQATDNEPVEMLHSGTLVPSRELPIAF 511
            |.:.|:.  |...|..:....:....:|:.|
  Fly   489 RNFHIEY--NYSTEKPYKCRFLYKPNIPLKF 517

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CYP24A1	NP_000773.2	p450	59..512	CDD:278495	141/492 (29%)
Cyp12c1	NP_001287109.1	p450	45..502	CDD:278495	139/475 (29%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	194	1.000	Domainoid score	I3171
eggNOG	1	0.900	-	-		E2759_KOG0159
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	201	1.000	Inparanoid score	I3768
Isobase	1	0.950	-	0	Normalized mean entropy	S4812
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D185685at33208
OrthoFinder	1	1.000	-	-		FOG0000720
OrthoInspector	1	1.000	-	-		mtm8467
orthoMCL	1	0.900	-	-		OOG6_100895
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2442
SonicParanoid	1	1.000	-	-		X156
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	11	10.750