Protein Alignment CYP24A1 and Cyp4d8

DIOPT Version :10

• Sequence 1: NP_000773.2
• Gene: CYP24A1 / 1591
• HGNCID: 2602
• Length: 514
• Species: Homo sapiens
• Sequence 2: NP_523961.2
• Gene: Cyp4d8 / 38841
• FlyBaseID: FBgn0015033
• Length: 505
• Species: Drosophila melanogaster
• Alignment Length: 483
• Identity: 117/483 - (24%)
• Similarity: 211/483 - (43%)
• Gaps: 84/483 - (17%)

Human    53 QNAAALPGPTSWPLLGSLLQILWKGGLKKQHDTLV----EYHKKYGKIFRMKLGSFESVHLGSPC 113
            :..|.||||...||:|: :|::    |:....|.:    ||..|:|.:.|:.:.:...:..|...
  Fly    26 RKVANLPGPICPPLIGA-MQLM----LRLNPKTFIKVGREYVLKFGHLQRVWIFNRLLIMSGDAE 85

Human   114 LLEALYRTES---AYPQRLEIKPWKAYRDYRKEGYGLLILEGEDWQRVRSAFQKKLMKPGEVMKL 175
            |.|.|..::.   .:|....:..|.        |.|||:.:|:.|.:     ::|::.|    ..
  Fly    86 LNEQLLSSQEHLVKHPVYKVLGQWL--------GNGLLLSDGKVWHQ-----RRKIITP----TF 133

Human   176 DNKINEVLADFMGRIDELCDER------GHVEDLYSELNKWSFESICL----VLYEKRFG---LL 227
            ...|.|...:...:...:|.:|      |:..|:|        .|||.    ::.|...|   ..
  Fly   134 HFSILEQFVEVFDQQSNICVQRLAQKANGNTFDVY--------RSICAAALDIIAETAMGTKIYA 190

Human   228 QKNAGD---EAVNFIMAIKT--MMSTFGRMMVTPVELHKSLN------TKVWQDHTLAWDTIFKS 281
            |.|...   ||||...|:.:  .||.:.::.:.....|..|.      .:..|:.|:   .:.:.
  Fly   191 QANESTPYAEAVNECTALLSWRFMSVYLQVELLFTLTHPHLKWRQTQLIRTMQEFTI---KVIEK 252

Human   282 VKACIDNRLEKYSQQPSADF-------LCDIYHQNR-----LSKKELYAAVTELQLAAVETTANS 334
            .:..::::..|.......|.       |.|:...:.     |:..|:...|........:||.::
  Fly   253 RRQALEDQQSKLMDTADEDVGSKRRMALLDVLLMSTVDGRPLTNDEIREEVDTFMFEGHDTTTSA 317

Human   335 LMWILYNLSRNPQVQQKLLKEIQSVL--PENQVPRAEDLRNMPYLKACLKESMRLTPSVPFTTRT 397
            |.:.|:.|||:|:||.|:|:||..||  ..::.....||..:.|::..:|||:|:.|.||...|.
  Fly   318 LSFCLHELSRHPEVQAKMLEEIVQVLGTDRSRPVSIRDLGELKYMECVIKESLRMYPPVPIVGRK 382

Human   398 LD---KAT--VLGEYALPKGTVLMLNTQVLGSSEDNFEDSSQFRPERWLQEKEKINPFAHLPFGV 457
            |.   |.|  |.|:..:|.|:.:::....:....:.|.:..:|.|||. :...::.||..:||..
  Fly   383 LQTDFKYTHSVHGDGVIPAGSEIIIGIFGVHRQPETFPNPDEFIPERH-ENGSRVAPFKMIPFSA 446

Human   458 GKRMCIGRRLAELQLHLALCWIVRKYDI 485
            |.|.|||::.|:|::.:.|..|||:|::
  Fly   447 GPRNCIGQKFAQLEMKMMLAKIVREYEL 474

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CYP24A1	NP_000773.2	CYP24A1	90..508	CDD:410738	104/442 (24%)
Cyp4d8	NP_523961.2	CYP4	66..497	CDD:410721	103/438 (24%)