Protein Alignment CYP24A1 and Cyp4d20

DIOPT Version :10

• Sequence 1: NP_000773.2
• Gene: CYP24A1 / 1591
• HGNCID: 2602
• Length: 514
• Species: Homo sapiens
• Sequence 2: NP_647723.2
• Gene: Cyp4d20 / 38311
• FlyBaseID: FBgn0035344
• Length: 510
• Species: Drosophila melanogaster
• Alignment Length: 502
• Identity: 131/502 - (26%)
• Similarity: 218/502 - (43%)
• Gaps: 102/502 - (20%)

Human    56 AALPGPTSWPLLGSLLQIL---------WKGGLKKQHDTLVEYHKKYGKIFRM-----------K 100
            :|:|||.|.|:||..||.|         |.|          |...||||.||.           .
  Fly    31 SAIPGPISIPILGCGLQALHLGAENIIGWVG----------EKFDKYGKTFRFWILGESLIYTKD 85

Human   101 LGSFESVHLGSPCLLE--ALYRTESAYPQRLEIKPWKAYRDYRKEGYGLLILEGEDWQRVRS--- 160
            |..||:: |.|..|||  .||.         .::|:  ..|      |||:..|..|...|.
  Fly    86 LQYFETI-LSSTTLLEKGQLYE---------YLRPF--LND------GLLVSTGRKWHARRKIFT 132

Human   161 -AFQKKLMKPGEVMKLDNKINEVLADFMGRIDELCDERGHVEDLYSELNKWSFESICLVLYEKRF 224
             ||..|:::  ..:::.::.:.|:.|   .:.::.|.:..|:.|     |:...:...|:.|...
  Fly   133 HAFHFKVLE--HYVEIMDRHSSVMVD---NLRKVADGKTAVDML-----KYVSLAALDVITEAAM 187

Human   225 GLLQKNAGDEAVNFIMAIKTM-------MSTFGRM------MVTPVELHKSL--NTKVWQDHTLA 274
            |:......|....:|.|:|::       |..|.|.      :..|: ||:.|  :.:|..|.|
  Fly   188 GVQVNAQNDPDFPYIKALKSVVYIQPDRMFRFSRRYNWLFPLAAPL-LHRQLLSDIRVMHDFT-- 249

Human   275 WDTIFKSVKACI---------------DNRLEKYSQQPSADFLCDIYHQNR-LSKKELYAAVTEL 323
             |.:....:..:               |..:...||....|.|......|: ||..::...|...
  Fly   250 -DKVISERRETVRRAKADGTYRPLSLGDAEIGSKSQMALLDILLQSSINNQPLSDADIREEVDTF 313

Human   324 QLAAVETTANSLMWILYNLSRNPQVQQKLLKEIQSVL-PENQVPRAE-DLRNMPYLKACLKESMR 386
            .....:||::.:...||.::|:|:|||::.:|:|.|| |:...|..: .|:::.||...:||:||
  Fly   314 MFEGDDTTSSGVSHALYAIARHPEVQQRIFEELQRVLGPDASAPVTQAQLQDLKYLDCVIKETMR 378

Human   387 LTPSVPFTTRTLDKATVLGEYALPKGTVLMLNTQVLGSSEDNFEDSSQFRPERWLQEKEK-INPF 450
            |.|.||...|...|...:|:..:|..|.:.|.........:.|.|...|||||:|:::|: .|.|
  Fly   379 LYPPVPAIGRHAQKELEIGDKTIPANTSIYLVLYYAHRDANYFPDPLSFRPERFLEDQEQGHNTF 443

Human   451 AHLPFGVGKRMCIGRRLAELQLHLALCWIVRKYDIQATDNEPVEMLH 497
            |::||..|.:.|||::.|.|::.:.:..::|.|::.....|...||:
  Fly   444 AYVPFSAGPKNCIGQKFAVLEMKVLISKVLRFYELLPLGEELKPMLN 490

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CYP24A1	NP_000773.2	CYP24A1	90..508	CDD:410738	117/459 (25%)
Cyp4d20	NP_647723.2	CYP4	68..501	CDD:410721	115/455 (25%)