Protein Alignment CYP24A1 and Cyp12b2

DIOPT Version :10

• Sequence 1: NP_000773.2
• Gene: CYP24A1 / 1591
• HGNCID: 2602
• Length: 514
• Species: Homo sapiens
• Sequence 2: NP_611370.2
• Gene: Cyp12b2 / 37163
• FlyBaseID: FBgn0034387
• Length: 535
• Species: Drosophila melanogaster
• Alignment Length: 487
• Identity: 129/487 - (26%)
• Similarity: 228/487 - (46%)
• Gaps: 49/487 - (10%)

Human    51 ETQNAAALPGPTSWPLLGSLLQILWKGGLKKQHDTLVEYHK----KYGKIFRM--KLGSFESVHL 109
            :.::...:|||:    |..:|.....||..: :..|::.::    .||.|:.:  .:|...:|..
  Fly    49 QARSFGEIPGPS----LLRMLSFFMPGGALR-NTNLIQMNRLMREMYGDIYCIPGMMGKPNAVFT 108

Human   110 GSPCLLEALYRTESAYPQRLEIKPWKAYR-----DYRKEGYGLLILEGEDWQRVRSAFQKKLMKP 169
            .:|...|..||.|..:|.|:.::....||     |..|...||...:|::|..:|:.....|||.
  Fly   109 YNPDDFEMTYRNEGVWPIRIGLESLNYYRKIHRPDVFKGVGGLASDQGQEWADIRNKVNPVLMKV 173

Human   170 GEVMKLDNKINEVLADFMGRIDELCDERGH--VEDLYSELNKWSFESICLVLYEKRFGLLQKNAG 232
            ..|.:...:::::..:|:.:::...:...|  ..|.:::|..|:||||..|....|.|||..|..
  Fly   174 QNVRQNLPQLDQISKEFIDKLETQRNPETHTLTTDFHNQLKMWAFESISFVALNTRMGLLSDNPD 238

Human   233 DEAVNFIMAIKTMMSTFGRMMVTPVELHKSLNTKVWQDHTLA--------WDTIFKSVKACIDNR 289
            ..|......::...:...:..|.|         .:|..:..|        :|.|.......|:..
  Fly   239 PNADRLAKHMRDFFNYSFQFDVQP---------SIWTFYKTAGFKKFLKTYDNITDITSNYIETA 294

Human   290 LEKYSQQPSADFLCDIYHQNRLSKKELYAAVTELQLAAVETTANSLMWILYNLSRNPQVQQKLLK 354
            :..:.:.......|.:......:||.....|.::.:|.::||:::.:.|||:|:|||..|:||.:
  Fly   295 MRGFGKNDDGKTKCVLEQLLEHNKKVAVTMVMDMLMAGIDTTSSACLTILYHLARNPSKQEKLRR 359

Human   355 EIQSVLPENQVPRA-EDLRNMPYLKACLKESMRLTPSVPFTTRTLDKATVLGEYALPKGTVLMLN 418
            |:..:||..:.... ::.:|||||:||:||.:|:|...|...|...|..||..|.:|:||.:::.
  Fly   360 ELLRILPTTKDSLTDQNTKNMPYLRACIKEGLRITSITPGNFRITPKDLVLSGYQVPRGTGVLMG 424

Human   419 TQVLGSSEDNFEDSSQFRPERWLQE-----------KEKINPFAHLPFGVGKRMCIGRRLAELQL 472
            ...|.:.:..|..||:|.|||||:.           ....|||.:||||.|.|.|||:|:|||::
  Fly   425 VLELSNDDKYFAQSSEFIPERWLKSDLAPDIQACPAARTRNPFVYLPFGFGPRTCIGKRIAELEI 489

Human   473 HLALCWIVRKYDIQATDNEPVEMLHSGTLVPS 504
            ...|..::|.|.:......|:|  :..|::.|
  Fly   490 ETLLVRLLRSYKVSWLPETPIE--YESTIILS 519

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CYP24A1	NP_000773.2	CYP24A1	90..508	CDD:410738	121/448 (27%)
Cyp12b2	NP_611370.2	CYP24A1-like	87..525	CDD:410677	121/444 (27%)