Protein Alignment CYP24A1 and Cyp4aa1

DIOPT Version :10

• Sequence 1: NP_000773.2
• Gene: CYP24A1 / 1591
• HGNCID: 2602
• Length: 514
• Species: Homo sapiens
• Sequence 2: NP_611067.2
• Gene: Cyp4aa1 / 36752
• FlyBaseID: FBgn0034053
• Length: 510
• Species: Drosophila melanogaster
• Alignment Length: 469
• Identity: 110/469 - (23%)
• Similarity: 195/469 - (41%)
• Gaps: 84/469 - (17%)

Human    58 LPGPTSWPLLGSLLQILWKGGLK----KQHDTLVEYHKKYGKIFRMKLGSFESVHLGSP----CL 114
            |.||.|.|.||:.:.:..|..::    |..|.       ||.:.|:.:..|....:..|    .:
  Fly    48 LTGPPSLPFLGNCMLVTDKDLMRRCAGKAFDL-------YGSLVRIWVLLFPFFAVLEPEDLQVI 105

Human   115 LEALYRTESAYPQRLEIKPWKAYRDYRKEGYGLLILEGEDWQRVRSAFQKKLMKPGEVMKLDNKI 179
            |.:...|...:..||.         :...|.||:...|..|..     .::|::|.....|..|.
  Fly   106 LSSKKHTNKVFFYRLM---------HNFLGDGLITSSGSKWSN-----HRRLIQPAFHHNLLEKF 156

Human   180 NEVLADFMGRIDELCDERGHVEDLYSELNKWSFESICL--VLYEKRFGLLQKNAGDEAVNFIMAI 242
            .:...|....:.|..|    .|.:.:|:|...:.:.|:  :|.|...|:..|..|.:.
  Fly   157 IDTFVDASQSLYENLD----AEAVGTEINIAKYVNNCVLDILNEAVLGVPIKKRGQDV------- 210

Human   243 KTMM--STF--GRMMVTPVELHKSLNTKVWQDHTLAWDTIFKSVKACID-----NRLEKYSQQP- 297
             .||  |.|  |::|: |...     |:.|    |..|.|:...|...|     .||..::::.
  Fly   211 -AMMEDSPFRQGKIMM-PARF-----TQPW----LLLDGIYHWTKMANDELNQKKRLNDFTRKMI 264

Human   298 ------------------SADFLCDIYHQNR-LSKKELYAAVTELQLAAVETTANSLMWILYNLS 343
                              ..|.:.:|...|| .:::::........||..::...::.:.|:.|:
  Fly   265 QRRRQIQNNNNGNSERKCLLDHMIEISESNRDFTEEDIVNEACTFMLAGQDSVGAAVAFTLFLLT 329

Human   344 RNPQVQQKLLKEIQSVLPE-NQVPRAEDLRNMPYLKACLKESMRLTPSVPFTTRTLDKATVLGEY 407
            :||:.|.:.:.|:.::..: |:.|...||..|.|::.|:||::||.||||...|.|.:...|.::
  Fly   330 QNPECQDRCVLELATIFEDSNRAPTMTDLHEMRYMEMCIKEALRLYPSVPLIARKLGEEVRLAKH 394

Human   408 ALPKGTVLMLNTQVLGSSEDNFEDSSQFRPERWLQE-KEKINPFAHLPFGVGKRMCIGRRLAELQ 471
            .||.|:.:.:...........:.|..:|:|||:..| .|..:|:|.|||..|.|.|||.|.|.::
  Fly   395 TLPAGSNVFICPYATHRLAHIYPDPEKFQPERFSPENSENRHPYAFLPFSAGPRYCIGNRFAIME 459

Human   472 LHLALCWIVRKYDI 485
            :...:..::|.|.:
  Fly   460 IKTIVSRLLRSYQL 473

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CYP24A1	NP_000773.2	CYP24A1	90..508	CDD:410738	100/433 (23%)
Cyp4aa1	NP_611067.2	CYP4	81..498	CDD:410721	99/429 (23%)