Protein Alignment CYP24A1 and Cyp301a1

DIOPT Version :9

• Sequence 1: NP_000773.2
• Gene: CYP24A1 / 1591
• HGNCID: 2602
• Length: 514
• Species: Homo sapiens
• Sequence 2: NP_610796.1
• Gene: Cyp301a1 / 36378
• FlyBaseID: FBgn0033753
• Length: 553
• Species: Drosophila melanogaster
• Alignment Length: 535
• Identity: 148/535 - (27%)
• Similarity: 252/535 - (47%)
• Gaps: 81/535 - (15%)

Human    25 PRLVTSTAYTSPQPREVPVCPLTAGGETQNAA---ALPGPTSWPLLGS---LLQILWKGGLKKQH 83
            |.|..|...::|:        :.:..|.|||.   .:|||...|:||:   |:.|:.:..:....
  Fly    47 PHLADSEEASAPR--------IHSTSEWQNALPYNQIPGPKPIPILGNTWRLMPIIGQYTISDVA 103

Human    84 DTLVEYHKKYGKIFRMKLGSFESVHLGSPCLL--------EALYRTESAYPQRLEIKPWKAYRD- 139
            ......|.:||:|.|  .|..    :|.|.||        |..||:|...|.|..:.....|:.
  Fly   104 KISSLLHDRYGRIVR--FGGL----IGRPDLLFIYDADEIEKCYRSEGPTPFRPSMPSLVKYKSV 162

Human   140 YRKEGY----GLLILEGEDWQRVRSAFQKKLMKPGEVMKLDNKINEVLADFMGRIDELCDERGHV 200
            .||:.:    |::.:.||.|:..||..||.:::...:.:....:..:..||:.|.:.|.||...:
  Fly   163 VRKDFFGDLGGVVGVHGEPWREFRSRVQKPVLQLSTIRRYLQPLEVITEDFLVRCENLLDENQEL 227

Human   201 -EDLYSELNKWSFESICLVLYEKRFGLLQKN--AGDEAVNFIMAIK---------TMMSTFGRMM 253
             ||..:|::|||.|.|..|..:.|.|.|:.|  ...|....|.|.|         .:.:.:.|..
  Fly   228 PEDFDNEIHKWSLECIGRVALDTRLGCLESNLKPDSEPQQIIDAAKYALRNVATLELKAPYWRYF 292

Human   254 VTPV--ELHKSLN------TKVWQDHTLAWDTIFKSVKACIDNRLEKYSQQPSADFLCDIYHQNR 310
            .||:  ...|::|      .|..|..|....|...|::|...:.:||..
  Fly   293 PTPLWTRYVKNMNFFVGVCMKYIQSATERLKTQDPSLRAGEPSLVEKVI---------------- 341

Human   311 LSKKELYAA---VTELQLAAVETTANSLMWILYNLSRNPQVQQKLLKEIQSVLPENQVPRAEDLR 372
            ||:|:...|   ..:|.|..::|.:.::..:||.|:..|..|||:.:|::.:||:...|....|.
  Fly   342 LSQKDEKIATIMALDLILVGIDTISMAVCSMLYQLATRPVDQQKVHEELKRLLPDPNTPLTIPLL 406

Human   373 N-MPYLKACLKESMRLTPSVPFTTRTLDKATVLGEYALPKGTVLMLNTQVLGSSEDNFEDSSQFR 436
            : |.:||..:||..|:..:|....|||.:.:|:..|.:|||...:..|.|.|:.|:...|::.||
  Fly   407 DQMHHLKGFIKEVFRMYSTVIGNGRTLMEDSVICGYQVPKGVQAVFPTIVTGNMEEYVTDAATFR 471

Human   437 PERWLQEKE-----KINPFAHLPFGVGKRMCIGRRLAELQLHLALCWIVRKYDIQATDNEPVEML 496
            |||||:.:.     |::|||.||:|.|.|||:|||.|:|::.:.|..::|.|.:: .:::|::
  Fly   472 PERWLKPQHGGTPGKLHPFASLPYGYGARMCLGRRFADLEMQILLAKLLRNYKLE-YNHKPLD-- 533

Human   497 HSGTLVPSRELPIAF 511
            ::.|.:.:.:.|:.|
  Fly   534 YAVTFMYAPDGPLRF 548

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CYP24A1	NP_000773.2	p450	59..512	CDD:278495	140/498 (28%)
Cyp301a1	NP_610796.1	p450	76..530	CDD:299894	136/476 (29%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	194	1.000	Domainoid score	I3171
eggNOG	1	0.900	-	-		E2759_KOG0159
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	201	1.000	Inparanoid score	I3768
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D185685at33208
OrthoFinder	1	1.000	-	-		FOG0000720
OrthoInspector	1	1.000	-	-		mtm8467
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X156
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	8	7.870