Protein Alignment CYP24A1 and Cyp4e2

DIOPT Version :10

• Sequence 1: NP_000773.2
• Gene: CYP24A1 / 1591
• HGNCID: 2602
• Length: 514
• Species: Homo sapiens
• Sequence 2: NP_477117.2
• Gene: Cyp4e2 / 35822
• FlyBaseID: FBgn0014469
• Length: 526
• Species: Drosophila melanogaster
• Alignment Length: 473
• Identity: 130/473 - (27%)
• Similarity: 217/473 - (45%)
• Gaps: 87/473 - (18%)

Human    60 GPTSWPLLGSLLQILWKGGLKKQH--DTLVEYHKKYGK-IFRMKLGSFESVHLGSPCLLEALYRT 121
            ||...||:|:..|:    |.....  ||:..:..:||| .|...:|::.:|.:.|...||.:..:
  Fly    35 GPRGLPLMGNAHQM----GKNPSEILDTVFSWWHQYGKDNFVFWIGTYSNVLVTSSKYLEFILSS 95

Human   122 ESAYPQRLEI----KPWKAYRDYRKEGYGLLILEGEDWQRVRS----AFQKKLMKP-GEVM---- 173
            ::.. .:.:|    .||.        |.|||...|..|.:.|.    ||...:::. .|||
  Fly    96 QTLI-TKSDIYQLTHPWL--------GLGLLTSTGSKWHKHRKMITPAFHFNILQDFHEVMNENS 151

Human   174 -KLDNKINEVLA-----DFMGR-----IDELCDER-----GHVEDLYSELNKWSFESICLVLYEK 222
             |....:..|.|     ||..:     :|.:||..     ..:|:..|.:.: :|:.:|..:..:
  Fly   152 TKFIKHLKTVAAGDNIFDFQEQAHYLTLDVICDTAMGVSINAMENRSSSIVQ-AFKDMCYNINMR 215

Human   223 RFGLLQKN------AGDEAVNFIMAIKTMMSTFGRMMVTPVELHKS--LNTKVWQDHT---LAW- 275
            .|..|::|      |.|... :...:||:......::...:|.|||  ::|....:.|   :|:
  Fly   216 AFHPLKRNELLYRLAPDYPA-YSRTLKTLQDFTNEIIAKRIEAHKSGAVSTNAGDEFTRKKMAFL 279

Human   276 DTIFKSVKACIDNRLEKYSQQPSADFLCDIYHQNRLSKKELYAAVTELQLAAVETTANSLMWILY 340
            ||:..|.   ||.|                    .|:.||||..|:.......:||.:.:.:.:|
  Fly   280 DTLLSST---IDGR--------------------PLNSKELYEEVSTFMFEGHDTTTSGVSFAVY 321

Human   341 NLSRNPQVQQKLLKEIQSVLPENQVPR---AEDLRNMPYLKACLKESMRLTPSVPFTTRTLDKAT 402
            .|||:...|:||.||.:.|:..:::.|   .:::..|.||...:||:.|:.|||||..|..:|..
  Fly   322 LLSRHQDEQRKLFKEQREVMGNSELGRDATFQEISQMKYLDLFIKEAQRVYPSVPFIGRFTEKDY 386

Human   403 VLGEYALPKGTVLMLNTQVLGSSEDNFEDSSQFRPERWLQEKEKINPFAHLPFGVGKRMCIGRRL 467
            |:....:||||.|.|...:||.:|..|:|..:|||||:  |.||..||.::||..|.|.|||::.
  Fly   387 VIDGDLVPKGTTLNLGLVMLGYNEKVFKDPHKFRPERF--ELEKPGPFEYVPFSAGPRNCIGQKF 449

Human   468 AELQLHLALCWIVRKYDI 485
            |.|::...:..|:|.:::
  Fly   450 ALLEIKTVVSKIIRNFEV 467

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CYP24A1	NP_000773.2	CYP24A1	90..508	CDD:410738	121/441 (27%)
Cyp4e2	NP_477117.2	CYP4	68..520	CDD:410721	119/436 (27%)