Protein Alignment CYP24A1 and Cyp4e3

DIOPT Version :10

• Sequence 1: NP_000773.2
• Gene: CYP24A1 / 1591
• HGNCID: 2602
• Length: 514
• Species: Homo sapiens
• Sequence 2: NP_523527.1
• Gene: Cyp4e3 / 34291
• FlyBaseID: FBgn0015035
• Length: 526
• Species: Drosophila melanogaster
• Alignment Length: 484
• Identity: 133/484 - (27%)
• Similarity: 206/484 - (42%)
• Gaps: 94/484 - (19%)

Human    60 GPTSWPLLGSL-------LQILWKGGLKKQHDTLVEYHKKYGK-IFRMKLGSFESVHLGSPCLLE 116
            |||..|:||:.       .:||         .|..::...||| .|...:|....:.:.:|..||
  Fly    35 GPTPVPILGNANRIGKNPAEIL---------STFFDWWYDYGKDNFLFWIGYSSHIVMTNPKQLE 90

Human   117 ALYRTESAYPQRLE-------IKPWKAYRDYRKEGYGLLILEGEDWQRVRSAFQKKLMKPG---- 170
            .:..::    |.::       :.||.        |:|||...|..|.:     .:|::.|.
  Fly    91 YILNSQ----QLIQKSTIYDLLHPWL--------GHGLLTSFGSKWHK-----HRKMITPSFHFN 138

Human   171 ------EVMKLDNKINEVLADFMGRI------DELCDERGHVEDLYSELNKWSFESIC------- 216
                  |||      ||..|.||.::      |.:.|.:.|.       |..:.:.||
  Fly   139 ILQDFHEVM------NENSAKFMTQLKKASAGDTIIDFQEHA-------NYLTLDVICDTAMGVP 190

Human   217 LVLYEKRFGLLQKNAGDEAVNFIMAIKTMMSTFGRMM-VTPVELHKSLNTKVWQDHTLAWDTIFK 280
            :...|:|...:.:...|...|..|..........|:. :||.........|..||.|  :|.|.|
  Fly   191 INAMEQRDSSIVQAFRDMCYNINMRAFHPFKRSNRVFSLTPEFSAYQKTLKTLQDFT--YDIIEK 253

Human   281 SVKACIDNRLEKYSQQPS--------ADFLCDIYHQNR-LSKKELYAAVTELQLAAVETTANSLM 336
            .|.| :.|...|....||        .|.|.......| |:::|:|..|:.......:||.:.:.
  Fly   254 RVYA-LQNGGSKEDHDPSLPRKKMAFLDTLLSSTIDGRPLTRQEIYEEVSTFMFEGHDTTTSGVS 317

Human   337 WILYNLSRNPQVQQKLLKEIQSVLPE--NQVPRAEDLRNMPYLKACLKESMRLTPSVPFTTRTLD 399
            :.:|.|||:|.||:||.:|...|:..  |:....:::..|.||...:||:.|:.|||||..|..|
  Fly   318 FSVYLLSRHPDVQRKLYREQCEVMGHDMNRSVSFQEIAKMKYLDLFIKEAQRVYPSVPFIGRYCD 382

Human   400 KATVLGEYALPKGTVLMLNTQVLGSSEDNFEDSSQFRPERWLQEKEKINPFAHLPFGVGKRMCIG 464
            |...:....:||||.|.|...:||.::..|:|...|||||:  |:||..||.:|||..|.|.|||
  Fly   383 KDYDINGSIVPKGTTLNLALILLGYNDRIFKDPHHFRPERF--EEEKPAPFEYLPFSAGPRNCIG 445

Human   465 RRLAELQLHLALCWIVRKYDIQATDNEPV 493
            ::.|.|:|...:..:||.:::....:|.|
  Fly   446 QKFALLELKTVISKVVRSFEVLPAVDELV 474

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CYP24A1	NP_000773.2	CYP24A1	90..508	CDD:410738	124/447 (28%)
Cyp4e3	NP_523527.1	CYP4	68..519	CDD:410721	122/442 (28%)