DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment CYP24A1 and Cyp4s3

DIOPT Version :10

Sequence 1:NP_000773.2 Gene:CYP24A1 / 1591 HGNCID:2602 Length:514 Species:Homo sapiens
Sequence 2:NP_573003.2 Gene:Cyp4s3 / 32444 FlyBaseID:FBgn0030615 Length:495 Species:Drosophila melanogaster


Alignment Length:507 Identity:129/507 - (25%)
Similarity:221/507 - (43%) Gaps:104/507 - (20%)


- Green bases have known domain annotations that are detailed below.


Human    55 AAALPGPTSWPLLGSLLQILWKGGLKKQHDTLVEYHKKYGKIFRMKLGSFESVHLGSPCLLEAL- 118
            |..|||||    :|.|:..:.||.:.   :.|.|..:|:|.:||:..|....|....|..::.| 
  Fly    32 AKTLPGPT----IGELIANVKKGEIL---NWLKELREKHGPVFRIWFGKDLMVMFTDPEDIKQLL 89

Human   119 ----YRTESAYPQRLEIKPWKAYRDYRKEGYGLLILEGEDWQRVRSAFQKKLMKPGEVMKLDNKI 179
                ..|:|...:.||  ||.        |.|||...||.|.|     ::||:.||...:     
  Fly    90 GNNQLLTKSRNYELLE--PWL--------GKGLLTNGGESWHR-----RRKLLTPGFHFR----- 134

Human   180 NEVLADFMGRIDELC---------DERGHVEDLYSELNKWSFESIC-LVLYEKRFGLLQKNAGDE 234
              :|::|...::|.|         ...|...|:|..:..::.::|| ..:..|:...||.::   
  Fly   135 --ILSEFKEPMEENCRILVRRLRTKANGESFDIYPYITLFALDAICETAMGIKKHAQLQSDS--- 194

Human   235 AVNFIMAIKTMMSTFGRMMVTPVELHKS-------LN-----TKVWQDHTLAWDTIFKSVKACID 287
              .::.|::::.    |:|      ||.       ||     ||..::...|...:.......|.
  Fly   195 --EYVQAVQSIC----RVM------HKQSFSFWQRLNVFFKHTKPGKEREAALKVLHDETNRVIR 247

Human   288 NRLEKYSQQ-----PSAD----------------FLCDIYHQNRLSKKELYAAVTELQLAAVETT 331
            .|.|:..|:     |.|:                .|..:.....||..::...|........:||
  Fly   248 LRREQLIQERNEWKPEAEQDDVGAKRRLAFLDMLLLTQMEGGAELSDTDIREEVDTFMFEGHDTT 312

Human   332 ANSLMWILYNLSRNPQVQQKLLKEIQSVLPENQVPRAEDLRNMPYLKACLKESMRLTPSVPFTTR 396
            ::::.:.|..||:||.|||:..:|...:       ...:..:||||:|.:||::|:.|||||.:|
  Fly   313 SSAIAFALSLLSKNPDVQQRAFEEASEL-------EGREKESMPYLEAVIKETLRIYPSVPFFSR 370

Human   397 TLDKATVLGEYALPKGTVLMLNTQVLGSSEDNFEDSSQFRPERWLQEKEKINPFAHLPFGVGKRM 461
            .:.:...:|:..:|||..:.....:|.....||.|..:|.|:|:|..:::::|||...|..|.|.
  Fly   371 KVLEDLEVGKLTVPKGASISCLIYMLHRDPKNFPDPERFDPDRFLVNEKQMHPFAFAAFSAGPRN 435

Human   462 CIGRRLAELQLHLALCWIVRKYD-IQATDNEPVEMLH----SGTLVPSRELP 508
            |||::.|.|:|..:|..::|.|. :...|::|..:..    ||..:..|.||
  Fly   436 CIGQKFAMLELKTSLAMLLRSYRFLPDKDHQPKPLAELVTKSGNGIRLRILP 487

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CYP24A1NP_000773.2 CYP24A1 90..508 CDD:410738 115/470 (24%)
Cyp4s3NP_573003.2 CYP4 64..483 CDD:410721 113/462 (24%)

Return to query results.
Submit another query.