Protein Alignment CYP24A1 and Cyp4ae1

DIOPT Version :10

• Sequence 1: NP_000773.2
• Gene: CYP24A1 / 1591
• HGNCID: 2602
• Length: 514
• Species: Homo sapiens
• Sequence 2: NP_525044.1
• Gene: Cyp4ae1 / 31193
• FlyBaseID: FBgn0015036
• Length: 496
• Species: Drosophila melanogaster
• Alignment Length: 475
• Identity: 121/475 - (25%)
• Similarity: 204/475 - (42%)
• Gaps: 73/475 - (15%)

Human    58 LPGPTSWPLLGSLLQI--LWKGGLKKQHDTLVEYHKKYGKIFRMKLGSFESVHLGSPCLLEALYR 120
            :|..:..||||:..|:  .....|   ||...||.|::|:       ||....||...::.|..|
  Fly    34 VPSVSRVPLLGAAWQMRSFQPDNL---HDKFAEYVKRFGR-------SFMGTVLGHVVMVTAEPR 88

Human   121 TESAYPQ-RLEIKPWKAYRDYRK-EGYGLLILEGEDWQRVRSAFQKKLMKPGEVMKLDNKINEVL 183
            ...|..| :.::|....|...|. .|.|||:..|::|..:|     |::.|    .....|.|..
  Fly    89 HIDALLQGQHQLKKGTMYFALRGWLGDGLLLSRGKEWHTMR-----KIITP----TFHFSILEQF 144

Human   184 ADFMGRIDELCDER-------GHVEDLYSELNKWSFESICLVLYEKRFGL-LQKNAGDEAVNFIM 240
            .:...|...:..||       ..|.::|..:...:.:    ::.|...|: :.....|..|  :.
  Fly   145 VEVFDRQSSILVERLRTLSYGNEVVNIYPLVGLAALD----IITETAMGVNVDAQGADSEV--VH 203

Human   241 AIKTMMSTFGRMMVTPVELHKSLNTKVWQDHTLAWDTIFKSVKA---C--------IDNRLEKYS 294
            |:|.:.:......:.|..|...|       ..|.|.:.|:..:|   |        |:.|....:
  Fly   204 AVKDLTNILATRFMRPHLLFPHL-------FRLCWPSGFRKQQAGVICLHEFTNGIIEQRRRLLA 261

Human   295 QQPSAD-----------FLCDIYHQNRLSKKELYAAVTELQLAAVETTANSLMWILYNLSRNPQV 348
            ::.:.|           .|........|:.|::...|........:||.:::.:.||.|||:..|
  Fly   262 REANQDKPTKPHALLDTLLRATVDGQPLTDKQIRDEVNTFIFEGHDTTTSAVSFCLYLLSRHEAV 326

Human   349 QQKLLKEIQSVLPENQVPRA--EDLRNMPYLKACLKESMRLTPSVPFTTRTLDKATVLGEYALPK 411
            ||||.:|::....::.....  .|...:|||...:|||:||.|.:|...|.|:|..|:.|..:|.
  Fly   327 QQKLFEELRMHYGQDLFRGVILSDFATLPYLSCVVKESLRLYPPIPAVARCLEKDLVIDEGYIPV 391

Human   412 GT-VLMLNTQVLGSSEDNFEDSSQFRPERWL-QEKEKINPFAHLPFGVGKRMCIGRRLAELQLHL 474
            || |::|..|:| ..|..|.|...|:|||.| :|..:::|::::||..|.|.|||::.|.|::..
  Fly   392 GTNVVVLLWQLL-RDEAIFTDPLVFQPERHLGEEAPRLSPYSYIPFSAGPRNCIGQKFALLEMKT 455

Human   475 ALCWIVRKYDI--QATDNEP 492
            .:..::|.|.:  ...|.||
  Fly   456 MVTKVIRHYQLLPMGADVEP 475

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CYP24A1	NP_000773.2	CYP24A1	90..508	CDD:410738	110/441 (25%)
Cyp4ae1	NP_525044.1	CYP4	76..489	CDD:410721	106/423 (25%)