Protein Alignment CYP24A1 and Cyp4d2

DIOPT Version :10

• Sequence 1: NP_000773.2
• Gene: CYP24A1 / 1591
• HGNCID: 2602
• Length: 514
• Species: Homo sapiens
• Sequence 2: NP_525043.1
• Gene: Cyp4d2 / 31192
• FlyBaseID: FBgn0011576
• Length: 501
• Species: Drosophila melanogaster
• Alignment Length: 486
• Identity: 125/486 - (25%)
• Similarity: 226/486 - (46%)
• Gaps: 71/486 - (14%)

Human    58 LPGPTSWPLLGSLLQILWKGGLKKQ-HDTLVEYHKKYGKIFRMKLGSFESVHLGSPCLLEALYRT 121
            ||||...|.||:||  :::|...:| .|.:.:..:|||:::|:.:....:|....|..:|.:..:
  Fly    31 LPGPRPLPFLGNLL--MYRGLDPEQIMDFVKKNQRKYGRLYRVWILHQLAVFSTDPRDIEFVLSS 93

Human   122 ESAYPQRLEIKPWKAYRDYRKEGYGLLILEGEDWQRVRSAFQKKLMKPGEVMKLDNKINEVLADF 186
            :....:....|....:.     |.|||:..|..|..     ::|::.|....|       :|..|
  Fly    94 QQHITKNNLYKLLNCWL-----GDGLLMSTGRKWHG-----RRKIITPTFHFK-------ILEQF 141

Human   187 MGRIDELCDERG--HVEDLYSELNKWS----FESICL----VLYEKRFGL---LQKNAG---DEA 235
            :    |:.|::.  .||.|.|..:..:    |..|||    ::.|...|.   .|||..   .:|
  Fly   142 V----EIFDQQSAVMVEQLQSRADGMTPINIFPVICLTALDIIAETAMGTKINAQKNPNLPYVQA 202

Human   236 VNFI--MAIKTMMSTFGRM-----MVTPVELHKSLNT-KVWQDHTLAWDTIFKSVKACIDNRLEK 292
            ||.:  :.||..:..:.|:     :..|.|..:.... ||..|.|   :.|.:..:..:.|..::
  Fly   203 VNDVTNILIKRFIHAWQRVDWIFRLTQPTEAKRQDKAIKVMHDFT---ENIIRERRETLVNNSKE 264

Human   293 YSQQPSADF--------LCDIYHQNR-----LSKKELYAAVTELQLAAVETTANSLMWILYNLSR 344
            .:.:...:|        |.|:..|:.     ||.:::...|........:||.:::.:.||.:||
  Fly   265 TTPEEEVNFLGQKRRMALLDVLLQSTIDGAPLSDEDIREEVDTFMFEGHDTTTSAISFCLYEISR 329

Human   345 NPQVQQKLLKEIQSVLPENQVP--RAEDLRNMPYLKACLKESMRLTPSVPFTTRTL-DKATVLGE 406
            :|:|||:|.:||:.||.|::..  ...||..:.:::..:|||:||.|.||...|.. :...:.|:
  Fly   330 HPEVQQRLQQEIRDVLGEDRKSPVTLRDLGELKFMENVIKESLRLHPPVPMIGRWFAEDVEIRGK 394

Human   407 YALPKGTVLMLNTQVLGSSEDNFEDSSQFRPERWLQEKEKINPFAHLPFGVGKRMCIGRRLAELQ 471
            : :|.||...:...||....:.||...:|||||:..:..:|:|:|::||..|.|.|||::.|.|:
  Fly   395 H-IPAGTNFTMGIFVLLRDPEYFESPDEFRPERFDADVPQIHPYAYIPFSAGPRNCIGQKFAMLE 458

Human   472 LHLALCWIVRKYDIQATDNEPVEMLHSGTLV 502
            :...:..::|.:::.....||   .||..:|
  Fly   459 MKSTVSKLLRHFELLPLGPEP---RHSMNIV 486

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CYP24A1	NP_000773.2	CYP24A1	90..508	CDD:410738	113/453 (25%)
Cyp4d2	NP_525043.1	CYP4	66..495	CDD:410721	111/449 (25%)