Protein Alignment CYP24A1 and Cyp12d1-d

DIOPT Version :10

• Sequence 1: NP_000773.2
• Gene: CYP24A1 / 1591
• HGNCID: 2602
• Length: 514
• Species: Homo sapiens
• Sequence 2: NP_995812.1
• Gene: Cyp12d1-d / 2768720
• FlyBaseID: FBgn0053503
• Length: 521
• Species: Drosophila melanogaster
• Alignment Length: 509
• Identity: 137/509 - (26%)
• Similarity: 259/509 - (50%)
• Gaps: 48/509 - (9%)

Human     5 ISKSRSLAAFLQQLRSPRQPPRLVTSTAYTSPQPREVPVCPLTAGGETQNAAALPGPTSWPLLGS 69
            :|.:||:|.::..:||.|....|....|.:|          :|...:|.:  .:|.|..:..:.:
  Fly     4 LSSARSVAIYVGPVRSSRSASVLAHEQAKSS----------ITEEHKTYD--EIPRPNKFKFMRA 56

Human    70 LLQILWKGGLKKQHDTLVEY----HKKYGKIFRM--KLGSFESVHLGSPCLLEALYRTESAYPQR 128
            .:    .|| :.|:.::.||    .|:||.|:.|  ..|..:.|...:...:|.::|.|..:|:|
  Fly    57 FM----PGG-EFQNASITEYTSAMRKRYGDIYVMPGMFGRKDWVTTFNTKDIEMVFRNEGIWPRR 116

Human   129 LEIKPWKAYRDY-RKEGY----GLLILEGEDWQRVRSAFQKKLMKPGEVMKLDNKINEVLADFMG 188
            ..:.....:|:: |.:.|    ||:..:.|.|.::|||.....|:|..:......::.:..:|:.
  Fly   117 DGLDSIVYFREHVRPDVYGEVQGLVASQNEAWGKLRSAINPIFMQPRGLRMYYEPLSNINNEFIE 181

Human   189 RIDELCDER--GHVEDLYSELNKWSFESICLVLYEKRFGLLQKNA-GDEAVNFIMAIKTMMSTFG 250
            ||.|:.|.:  ...||...|:::..|||:.||.::::.||::||. ..:|:......:.:.....
  Fly   182 RIKEIRDPKTLEVPEDFTDEISRLVFESLGLVAFDRQMGLIRKNRDNSDALTLFQTSRDIFRLTF 246

Human   251 RMMVTPVELHKSLNTKVWQ--DHTLAWDTIFKSVKACIDNR--LEKYSQQPSADFLCDIYHQNRL 311
            ::.:.| .:.|.::|..::  ..||. |::..|.|...:|:  |||..|  :.:.:.......||
  Fly   247 KLDIQP-SMWKIISTPTYRKMKRTLN-DSLNVSQKMLKENQDALEKRRQ--AGEKINSNSMLERL 307

Human   312 SKKELYAAV---TELQLAAVETTANSLMWILYNLSRNPQVQQKLLKEIQSVLP-ENQVPRAEDLR 372
            .:.:...||   .::..|.|:.||..|..:|..||::|..|.||.:|:.|::| ::.:...|:::
  Fly   308 MEIDPKVAVIMSLDILFAGVDATATLLSAVLLCLSKHPDKQAKLREELLSIMPTKDSLLNEENMK 372

Human   373 NMPYLKACLKESMRLTPSVPFTTRTLDKATVLGEYALPKGTVLMLNTQVLGSSEDNFEDSSQFRP 437
            :||||:|.:||::|..|:...|.||.....:|..|.:||||.::|.:.||......:....:|.|
  Fly   373 DMPYLRAVIKETLRYYPNGFGTMRTCQNDVILSGYRVPKGTTVLLGSNVLMKEATYYPRPDEFLP 437

Human   438 ERWLQEKE-----KINPFAHLPFGVGKRMCIGRRLAELQLHLALCWIVRKYDIQ 486
            ||||::.|     :::||..||||.|.|||||:|:.:|::...:..::|.:.::
  Fly   438 ERWLRDPETGKKMQVSPFTFLPFGFGPRMCIGKRVVDLEMETTVAKLIRNFHVE 491

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CYP24A1	NP_000773.2	CYP24A1	90..508	CDD:410738	118/420 (28%)
Cyp12d1-d	NP_995812.1	CYP24A1-like	76..515	CDD:410677	118/420 (28%)