DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment USP51 and Usp51

DIOPT Version :9

Sequence 1:	NP_958443.1	Gene:	USP51 / 158880	HGNCID:	23086	Length:	711	Species:	Homo sapiens
Sequence 2:	NP_001101722.1	Gene:	Usp51 / 317398	RGDID:	1562211	Length:	696	Species:	Rattus norvegicus

Alignment Length:	715	Identity:	545/715 - (76%)
Similarity:	595/715 - (83%)	Gaps:	23/715 - (3%)

- Green bases have known domain annotations that are detailed below.

Human     1 MAQVRETSLPSGSGVRWISGGGGGASPEEAVEKAGKMEEAAAGATKASSRREAEEMKLEPLQERE 65
            ||.|||.|..|.|...|.||||.||..|:|.|.|.:||:...|.      :.|:|||.|...|.:
  Rat     1 MAHVREASRSSRSVACWSSGGGRGACLEQAAENASRMEQTMRGT------QGAQEMKPELWPEPK 59

Human    66 PAPEENLTWSSSGGDEKVLPSIPLRCHSSSSPVCPRRKPRPRPQPRARSRSQPGLSAPPPPPARP 130
            |. .||||...||.|||||||||..||:|||.||||||||||||||:|||...||.|||||||:|
  Rat    60 PT-SENLTSRGSGSDEKVLPSIPAACHTSSSSVCPRRKPRPRPQPRSRSRGGRGLKAPPPPPAKP 123

Human   131 PPPPP-PPPPPAPRPR--AWRGSRRRSRPGSRPQTRRSCSGDLDGSGDPGGLGDWLLEVEFGQGP 192
            ||||| |||||.|:||  |||.||||.||..|||||:|...|...|||..|..:.||||.|.:||
  Rat   124 PPPPPAPPPPPLPKPRPVAWRNSRRRPRPAPRPQTRKSYPSDPGCSGDSDGTENRLLEVGFDKGP 188

Human   193 TGCSHVESFKVGKNWQKNLRLIYQRFVWSGTPETRKRKAKSCICHVCSTHMNRLHSCLSCVFFGC 257
            |||||||.|||.|||::|||:|||||:|||||||||||||:|||.|||||.||||||||||||||
  Rat   189 TGCSHVEIFKVAKNWRRNLRMIYQRFIWSGTPETRKRKAKTCICRVCSTHKNRLHSCLSCVFFGC 253

Human   258 FTEKHIHKHAETKQHHLAVDLYHGVIYCFMCKDYVYDKDIEQIAKETKEKILRLLTSTSTDVSHQ 322
            |||||||.|||||||:|||||||||||||||||||||||||:||||||||||.||.||:.|:|:|
  Rat   254 FTEKHIHIHAETKQHNLAVDLYHGVIYCFMCKDYVYDKDIEKIAKETKEKILGLLMSTAGDMSYQ 318

Human   323 QFMTSGFEDKQSTCETKEQEPKLVKPKKKRRKKSV-YTVGLRGLINLGNTCFMNCIVQALTHIPL 386
            |.|.|..|:.||.||:||||..|||||||||||:| |||||||||||||||||||||||||.|||
  Rat   319 QLMASEVEENQSICESKEQETSLVKPKKKRRKKTVYYTVGLRGLINLGNTCFMNCIVQALTRIPL 383

Human   387 LKDFFLSDKHKCIMTSPSLCLVCEMSSLFHAMYSGSRTPHIPYKLLHLIWIHAEHLAGYRQQDAH 451
            ||:|||||||||:||||||||||||||||.|||||:::|||||||||||||||||||||||||||
  Rat   384 LKEFFLSDKHKCMMTSPSLCLVCEMSSLFQAMYSGNQSPHIPYKLLHLIWIHAEHLAGYRQQDAH 448

Human   452 EFLIAILDVLHRHSKDDSGGQEANNPNCCNCIIDQIFTGGLQSDVTCQACHSVSTTIDPCWDISL 516
            ||||||||||||||:|| |.::..|.|.||||||.|||||||||||||.||.|||||||||||||
  Rat   449 EFLIAILDVLHRHSRDD-GIEQEGNLNHCNCIIDYIFTGGLQSDVTCQVCHGVSTTIDPCWDISL 512

Human   517 DLPGSCATFDSQNPERADSTVSRDDHIPGIPSLTDCLQWFTRPEHLGSSAKIKCNSCQSYQESTK 581
            |||      .|..|.||.||..:    |.:.||||||:||||||.|||||||||:.|||||:|||
  Rat   513 DLP------VSYTPGRAGSTGQK----PRVISLTDCLKWFTRPEDLGSSAKIKCSRCQSYQQSTK 567

Human   582 QLTMKKLPIVACFHLKRFEHVGKQRRKINTFISFPLELDMTPFLASTKESRMKEGQPPTDCVPNE 646
            ||||||||||||||||||||:|||||||||||||||||||||||||||||.|| |||.|:|||.|
  Rat   568 QLTMKKLPIVACFHLKRFEHLGKQRRKINTFISFPLELDMTPFLASTKESIMK-GQPLTECVPIE 631

Human   647 NKYSLFAVINHHGTLESGHYTSFIRQQKDQWFSCDDAIITKATIEDLLYSEGYLLFYHKQGLEKD 711
            |||||||||||||||||||||||:||:||||||||||::||||:|:||||||||||||:|.:||:
  Rat   632 NKYSLFAVINHHGTLESGHYTSFVRQEKDQWFSCDDAVVTKATMEELLYSEGYLLFYHRQDIEKE 696

Human 712 711
Rat 697 696

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
USP51	NP_958443.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..174		105/175 (60%)
		zf-UBP	236..296	CDD:280334	55/59 (93%)
		UCH	362..703	CDD:278850	283/340 (83%)
		Peptidase_C19D	363..704	CDD:239125	283/340 (83%)
Usp51	NP_001101722.1	zf-UBP	232..292	CDD:396634	55/59 (93%)
Usp51	NP_001101722.1	Peptidase_C19D	360..689	CDD:239125	283/340 (83%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C83685489
Domainoid	1	1.000	581	1.000	Domainoid score	I5178
eggNOG	1	0.900	-	-		E1_KOG1867
HGNC	1	1.500	-	-
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H71495
Inparanoid	1	1.050	1096	1.000	Inparanoid score	I4730
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG59954
OrthoDB	1	1.010	-	-		D147966at7742
OrthoFinder	1	1.000	-	-		FOG0002382
OrthoInspector	1	1.000	-	-		oto131590
orthoMCL	1	0.900	-	-		OOG6_102914
Panther	1	1.100	-	-	LDO	PTHR21646
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1575
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	18	18.270