DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment USP51 and ubp8

DIOPT Version :9

Sequence 1:	NP_958443.1	Gene:	USP51 / 158880	HGNCID:	23086	Length:	711	Species:	Homo sapiens
Sequence 2:	NP_592992.1	Gene:	ubp8 / 2542135	PomBaseID:	SPAC13A11.04c	Length:	449	Species:	Schizosaccharomyces pombe

Alignment Length:	519	Identity:	161/519 - (31%)
Similarity:	238/519 - (45%)	Gaps:	96/519 - (18%)

- Green bases have known domain annotations that are detailed below.

Human   194 GCSHVESFKVG-KNWQKNLRLIYQ-RFVWSGTPETRKRKAKSCICHVCSTHMNRLHSCLSCVFFG 256
            ||.|::..... :|:||....|:. .||        .|:     |..|.....|...||||...|
pombe     7 GCQHLKLKPADVENYQKICTQIFSCHFV--------PRR-----CSTCKRINKRSIRCLSCHSVG 58

Human   257 CFTEKHIHKHAETKQHHLAVDLYHGVIYCFMCKDYVYDKDIEQIAKETKEKILRLLTSTSTDVSH 321
            |....|..:||....|.:.||:.:|..|||.|:||||..::|.:..:.|.     :.:..:|  |
pombe    59 CLWGHHGEEHAMEHTHMIGVDVKNGHTYCFGCQDYVYQTELETLRFKIKN-----IKAWQSD--H 116

Human   322 QQFMTSGFEDKQSTC-ETKEQEPKLVKPKKKRRKKSVYTVGLRGLINLGNTCFMNCIVQALTHIP 385
            ::...   :..|..| |...:.|.:..           |.||||:.|||.||||:.|:|::.|.|
pombe   117 KRLPE---KYNQMVCLEAYRKYPPVCA-----------TAGLRGIQNLGATCFMSVILQSILHNP 167

Human   386 LLKDFFLSDKHKCIMTSPSLCLVCEMSSLFHAMYSGSR--TPHIPYKLLHLIWIHAEHLAGYRQQ 448
            |:::.|.|..|.........|:.|.:..:|.::|:...  |.:.|..:|:|:|..::.|.||.||
pombe   168 LVRNLFFSGFHTSTDCKRPTCMTCAIDDMFSSIYNSKNKSTFYGPTAVLNLMWKLSKSLCGYSQQ 232

Human   449 DAHEFLIAILDVLHRHSKDDSGGQEANNPNCCNCIIDQIFTGGLQSDVTCQACHSVSTTIDPCWD 513
            |.|||.:.:||.:|    .:||| ..:.|  |.|.|.:||:|.|::.|||..|......:||..|
pombe   233 DGHEFFVYLLDQMH----TESGG-GTSMP--CTCPIHRIFSGSLKNVVTCLDCKKERVAVDPLMD 290

Human   514 ISLDLPGSCATFDSQNPERADSTVSRDDHIPGIPSLTDCLQWFTRPEHLGSSAKIKCNSCQSYQE 578
            ||||:                          ..|:|..||:.|...|    ..:..|:||.| :.
pombe   291 ISLDI--------------------------NEPTLQGCLERFVSKE----KVQYSCHSCGS-KN 324

Human   579 STKQLTMKKLPIVACFHLKRFEHVG-KQRRKINTFISFPLELDMTPFLASTKESRMKEGQPPTDC 642
            :.|||...|||...|..|||||... ....||:..:|:|..|.|          |....|...|
pombe   325 AIKQLVFDKLPPTICMQLKRFEQNNFAMSTKIDKQVSYPAFLRM----------RYNFNQDDVD- 378

Human   643 VPNENKYSLFAVINHHGTLESGHYTSFIRQQKDQWFSCDDAIITKATIEDLLYSEGYLLFYHKQ 706
                  |.|::|:.|.|||::|||.::...| :|||..||..|.:....::|.|:.||||||::
pombe   379 ------YQLYSVVCHKGTLDTGHYIAYTYYQ-NQWFLLDDTTIVEVKESEVLNSQAYLLFYHER 435

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
USP51	NP_958443.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..174
		zf-UBP	236..296	CDD:280334	24/59 (41%)
		UCH	362..703	CDD:278850	114/343 (33%)
		Peptidase_C19D	363..704	CDD:239125	114/343 (33%)
ubp8	NP_592992.1	ZnF_UBP	37..85	CDD:197632	16/52 (31%)
		UCH	144..432	CDD:278850	114/343 (33%)
		Peptidase_C19D	145..433	CDD:239125	114/343 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	53	1.000	Domainoid score	I3690
eggNOG	1	0.900	-	-		E1_KOG1867
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	233	1.000	Inparanoid score	I987
OMA	1	1.010	-	-		QHG59954
OrthoFinder	1	1.000	-	-		FOG0002382
OrthoInspector	1	1.000	-	-		otm53510
orthoMCL	1	0.900	-	-		OOG6_102914
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1575
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	11	10.730