DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ZDHHC15 and Hip14

DIOPT Version :9

Sequence 1:	NP_659406.1	Gene:	ZDHHC15 / 158866	HGNCID:	20342	Length:	337	Species:	Homo sapiens
Sequence 2:	NP_001261910.1	Gene:	Hip14 / 39747	FlyBaseID:	FBgn0259824	Length:	655	Species:	Drosophila melanogaster

Alignment Length:	181	Identity:	47/181 - (25%)
Similarity:	85/181 - (46%)	Gaps:	30/181 - (16%)

- Green bases have known domain annotations that are detailed below.

Human    19 VLSWVPVLVIVLVVLWSYYAYVFELCLVTVLSPAEKVIYLILYHAIFVFFTWTYWKSIFTLPQQP 83
            :::.:|:.|.:....|.|..::  :.:...:|....|.:||....::|.|..: ||.      .|
  Fly   346 LMALLPLSVYLATKAWFYVTWL--MYIDDAVSFTATVCFLISSLLLWVCFLKS-WKG------DP 401

Human    84 NQKFHLSYTDKERYENEERPEVQKQMLVDMAKKLPVYTRTGSG--AVRFCDRCHLIKPDRCHHCS 146
            .   .:..|.::|::.          ::::::      |.|.|  ...||..|.:.:|.|..|||
  Fly   402 G---IIRPTREQRFKT----------IIELSE------RGGIGFEPASFCSGCLVRRPIRSKHCS 447

Human   147 VCAMCVLKMDHHCPWVNNCIGFSNYKFFLQFLAYSVLYCLYIATTVFSYFI 197
            ||..||.:.|||||||.||||..|:.:|:.||...::.|.::......|::
  Fly   448 VCDRCVARFDHHCPWVGNCIGLKNHSYFMGFLWMLLIMCAWMLYGGSKYYV 498

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ZDHHC15	NP_659406.1	zf-DHHC	<126..308	CDD:327686	30/74 (41%)
ZDHHC15	NP_659406.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	306..337
Hip14	NP_001261910.1	ANK	52..165	CDD:238125
		Ank_2	52..142	CDD:289560
		ANK repeat	77..108	CDD:293786
		ANK repeat	110..142	CDD:293786
		ANK	114..233	CDD:238125
		Ank_2	116..209	CDD:289560
		ANK repeat	144..175	CDD:293786
		ANK repeat	177..209	CDD:293786
		Ank_5	198..251	CDD:290568
		ANK repeat	212..244	CDD:293786
		zf-DHHC	426..559	CDD:279823	29/73 (40%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5273
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810