DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ZDHHC15 and Patsas

DIOPT Version :9

Sequence 1:	NP_659406.1	Gene:	ZDHHC15 / 158866	HGNCID:	20342	Length:	337	Species:	Homo sapiens
Sequence 2:	NP_001356957.1	Gene:	Patsas / 34634	FlyBaseID:	FBgn0029137	Length:	613	Species:	Drosophila melanogaster

Alignment Length:	302	Identity:	70/302 - (23%)
Similarity:	111/302 - (36%)	Gaps:	92/302 - (30%)

- Green bases have known domain annotations that are detailed below.

Human     4 GWKMALSGGLRCCRRVLSWVPVLVIVLVVLWSYYAYVFELCLVT--VLSPAEKVIYLILYHAIFV 66
            ||   |.||....:..|    .|.:..|:||.|..|:.....:|  :|..:.   |..:|....:
  Fly   355 GW---LFGGAGDSKGPL----FLFLFSVLLWGYPMYMIRAIPITWNILRRSH---YCFIYWNAVM 409

Human    67 FFTW----------------TYWKSIFTLPQQPNQKFHLSYTDKERYENEERPEVQKQMLVDMAK 115
            :.:|                .|:::|..:|          |.||.:..|        .||
  Fly   410 WISWAIANRRDPGYIPLSSDAYYRAIKQIP----------YFDKLKKRN--------VML----- 451

Human   116 KLPVYTRTGSGAVRFCDRCHLIKPDRCHHCSVCAMCVLKMDHHCPWVNNCIGFSNYKFFLQFLAY 180
                        .|.|..|..::|.|..||.||..||...|||||::.||:|..|..:|..|:..
  Fly   452 ------------TRLCHSCRCLRPLRAKHCRVCNRCVSYFDHHCPFIYNCVGLRNRMWFFLFVLS 504

Human   181 SVLYCLYIATTVFSYFIKYWRGELPSVRSKFHVLFLLFVACMFFVSLVILFGYHCWLVS------ 239
            ..:.|.:  |..|:.:.....|        |.:|::|.:     :..|:..|.. |:::
  Fly   505 VAVNCSF--TIYFACYCVMIEG--------FTMLYVLGL-----IEAVVFCGLG-WILTCTSILH 553

Human   240 --RNKTTLEAFCTPVF-----TSGPEKNGFNLGFIKNIQQVF 274
              .|.||.|.|....:     ..|..:|.|:.|.|.|:.:.|
  Fly   554 ACMNLTTNEMFNYKRYPYLRDKRGRYQNPFSRGPILNLLEFF 595

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ZDHHC15	NP_659406.1	zf-DHHC	<126..308	CDD:327686	44/162 (27%)
ZDHHC15	NP_659406.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	306..337
Patsas	NP_001356957.1	ANKYR	113..306	CDD:223738
		ANK repeat	148..181	CDD:293786
		ANK repeat	187..214	CDD:293786
		ANK repeat	216..247	CDD:293786
		ANK repeat	249..280	CDD:293786
		ANK repeat	282..314	CDD:293786
		Ank_4	283..336	CDD:316185
		DHHC	455..567	CDD:334580	36/127 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5273
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810