DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment AWAT2 and CG1946

DIOPT Version :9

Sequence 1:	NP_001002254.1	Gene:	AWAT2 / 158835	HGNCID:	23251	Length:	333	Species:	Homo sapiens
Sequence 2:	NP_610319.2	Gene:	CG1946 / 35720	FlyBaseID:	FBgn0033216	Length:	349	Species:	Drosophila melanogaster

Alignment Length:	346	Identity:	112/346 - (32%)
Similarity:	180/346 - (52%)	Gaps:	44/346 - (12%)

- Green bases have known domain annotations that are detailed below.

Human     3 LPSKKDLKTALDVFAVFQWSFSALLITTTV-IAVNLYLVVFTPYWPVTVLILTWLAF-----DWK 61
            :|.::.|:|.:..|  |.::|..|.|::.: :|:.||      |..:.|..|..:.|     |:|
  Fly    10 VPLERRLQTLVTSF--FTYTFFTLPISSCLAVAILLY------YGEMFVRSLLLIYFVKIYLDYK 66

Human    62 TPQRGGRRFTCVR---------HWRLWKHYSDYFPLKLLKTHDICPSRNYILVCHPHGLFAHGWF 117
                  |.:..:.         :||    |.:|||::|:||.::.|:||||:...|||:...|..
  Fly    67 ------RNYGIMEGNGWLFYRSNWR----YRNYFPVELVKTAELPPNRNYIVASFPHGILGTGTC 121

Human   118 GHFATEASGFSKIFPGITPYILTLGAFFWMPFLREYVMSTGACSVSRSSIDFLLT------HKG- 175
            .:.:.:...:..::|.:.|.|.||...|..||||:.:...|..|||:.|:.:||:      ||.
  Fly   122 INMSLDIDNWLSLYPHVRPKIATLDHHFKTPFLRDILRWWGMVSVSKESLSYLLSKSNDPMHKDN 186

Human   176 ----TGNMVIVVIGGLAECRYSLPGSSTLVLKNRSGFVRMALQHGVPLIPAYAFGETDLYDQHIF 236
                |.|.|.|::||..|...|.||...|.||:|.|||:||::.|..::|:.:|||.|::||...
  Fly   187 RDGFTSNAVAVLVGGAKEAMDSHPGQYILTLKDRKGFVKMAVRTGSSIVPSLSFGEVDIFDQVAN 251

Human   237 TPGGFVNRFQKWFQSMVHIYPCAFYGRGFTKNSWGLLPYSRPVTTIVGEPLPMPKIENPSQEIVA 301
            .|...:.|||...:....|.|....|||....::|:||:.|.:..:||.|:.:.:.|.|..|.|.
  Fly   252 PPDSSLRRFQNVVKKFTGISPLLPKGRGIFNYNYGILPHRRRIVQVVGSPIDVERCETPDPEYVD 316

Human   302 KYHTLYIDALRKLFDQHKTKF 322
            |.|...||||.::||::|.|:
  Fly   317 KIHGQVIDALARMFDEYKEKY 337

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AWAT2	NP_001002254.1	LPLAT	38..332	CDD:388412	102/310 (33%)
CG1946	NP_610319.2	LPLAT	80..349	CDD:302626	94/262 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165146793
Domainoid	1	1.000	214	1.000	Domainoid score	I2726
eggNOG	1	0.900	-	-		E1_KOG0831
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	235	1.000	Inparanoid score	I3400
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53531
OrthoDB	1	1.010	-	-		D1347007at2759
OrthoFinder	1	1.000	-	-		FOG0000289
OrthoInspector	1	1.000	-	-		mtm8637
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12317
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X186
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	12	11.870