DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment AWAT2 and Dgat2

DIOPT Version :9

Sequence 1:	NP_001002254.1	Gene:	AWAT2 / 158835	HGNCID:	23251	Length:	333	Species:	Homo sapiens
Sequence 2:	NP_610318.1	Gene:	Dgat2 / 35719	FlyBaseID:	FBgn0033215	Length:	352	Species:	Drosophila melanogaster

Alignment Length:	339	Identity:	114/339 - (33%)
Similarity:	187/339 - (55%)	Gaps:	27/339 - (7%)

- Green bases have known domain annotations that are detailed below.

Human     3 LPSKKDLKTALDVFAVFQWSFSALLITTTVIAVNLYLVVFTPYWP---VTVLILTWLAFDW---K 61
            :|.::.|:..:..|      |:::|:  .:::|:..||..:..:.   |..|::|:||:.:   |
  Fly    10 VPLERRLQILVTAF------FTSMLL--ILLSVSFLLVAGSLIYGGLLVRSLMVTYLAYVFVHHK 66

Human    62 TPQR--GGRRFTCVRHWRLWKHYSDYFPLKLLKTHDICPSRNYILVCHPHGLFAHGWFGHFATEA 124
            ..|.  .|..:...|...|.:||.||||::|:||.::..::||||...|||:...|...:...|.
  Fly    67 KTQSVVDGNGWMITRTNLLHRHYRDYFPVELVKTAELPATKNYILASFPHGILGTGIGINMGLEI 131

Human   125 SGFSKIFPGITPYILTLGAFFWMPFLREYVMSTGACSVSRSSIDFLLT------HKG-----TGN 178
            |.:.::||.:.|.:.||...|.:||:||.:...|..|||:.::..:|:      ||.     |.|
  Fly   132 SKWLELFPQVRPKLGTLDQHFHVPFMREVLRCWGLVSVSKEALIRMLSKSNDPKHKDNRDGFTSN 196

Human   179 MVIVVIGGLAECRYSLPGSSTLVLKNRSGFVRMALQHGVPLIPAYAFGETDLYDQHIFTPGGFVN 243
            .|.:::||..|...|.||...|.||||.||||||::.|..::|:::|||.|::||....|...:.
  Fly   197 AVAILVGGAQEAMDSHPGQYILTLKNRKGFVRMAIRTGSSIVPSFSFGEVDIFDQVANPPNSLLR 261

Human   244 RFQKWFQSMVHIYPCAFYGRGFTKNSWGLLPYSRPVTTIVGEPLPMPKIENPSQEIVAKYHTLYI 308
            |||.:.:.:..:.|....||||...::|.||:.|.:..:||.|:.:.|.|:|..|.|.|.|...|
  Fly   262 RFQDFVKKLTGVSPLIPVGRGFFNYTFGFLPFRRRIVQVVGAPIDVVKNEHPDSEYVDKVHGQVI 326

Human   309 DALRKLFDQHKTKF 322
            ::|.|||||:|.|:
  Fly   327 ESLEKLFDQYKDKY 340

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AWAT2	NP_001002254.1	LPLAT	38..332	CDD:388412	108/304 (36%)
Dgat2	NP_610318.1	LPLAT	74..340	CDD:302626	98/265 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165146794
Domainoid	1	1.000	214	1.000	Domainoid score	I2726
eggNOG	1	0.900	-	-		E1_KOG0831
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	235	1.000	Inparanoid score	I3400
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53531
OrthoDB	1	1.010	-	-		D1347007at2759
OrthoFinder	1	1.000	-	-		FOG0000289
OrthoInspector	1	1.000	-	-		mtm8637
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12317
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X186
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	12	11.870