DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CYP19A1 and Cyp4e1

DIOPT Version :9

Sequence 1:	NP_000094.2	Gene:	CYP19A1 / 1588	HGNCID:	2594	Length:	503	Species:	Homo sapiens
Sequence 2:	NP_524771.1	Gene:	Cyp4e1 / 44632	FlyBaseID:	FBgn0015034	Length:	531	Species:	Drosophila melanogaster

Alignment Length:	519	Identity:	133/519 - (25%)
Similarity:	216/519 - (41%)	Gaps:	93/519 - (17%)

- Green bases have known domain annotations that are detailed below.

Human    26 MPVLLLT----GLF---LLVWNYEGTSSIP--GPGYCMGIGPLISHGRFL-------------WM 68
            :|:.|:|    ||.   .::..::|.|.:|  |..:.||..|.....||.             |:
  Fly    11 LPLFLVTYFELGLLRRKRMLNKFQGPSMLPLVGNAHQMGNTPTEILNRFFGWWHEYGKDNFRYWI 75

Human    69 GIGSACNYYNRVYGEFMRVWISGEETLIISKSSSMFHIMKHNHYSSRFGSKLGLQCIGMHEKGII 133
            |..|.....|..|.||    |...:|||   |.|..:.:.|        ..|||        |::
  Fly    76 GYYSNIMVTNPKYMEF----ILSSQTLI---SKSDVYDLTH--------PWLGL--------GLL 117

Human   134 FNNNPELWKTTRPFFMKALSGPGLVRMVTVCAESLKTHLDRLEEVTNESGYVD------VLTLLR 192
            .:...: |...|.....|.....|.....|..|:....:|:|::|.:.....|      .|||
  Fly   118 TSTGSK-WHKHRKMITPAFHFNILQDFHEVMNENSTKFIDQLKKVADGGNIFDFQEEAHYLTL-- 179

Human   193 RVMLDTSNTLFLRIPLDESAIVVKIQGY-----------FDAWQALLIKPDIFFKISWLYKKYEK 246
            .|:.||:..:.:....:.|:.||  |.:           |..|:    :....|..:..|.:|.|
  Fly   180 DVICDTAMGVSINAMENRSSSVV--QAFKDITYTIKMRAFSPWK----RNKYLFHFAPEYPEYSK 238

Human   247 SVKDLKDAIEVLIA---EKRRR-----ISTEEKLEECMDFATELILAEKRG-DLTRENVNQCILE 302
            ::|.|:|....:||   |.|:.     |..:|...:.|.|...|:.::..| .||.:.:.:.:..
  Fly   239 TLKTLQDFTNEIIAKRIEVRKSGLEVGIKADEFSRKKMAFLDTLLSSKVDGRPLTSQELYEEVST 303

Human   303 MLIAAPDTMSVSLFFMLFLIAKHPNVEEAIIKEIQTVIGE----RDIKIDDIQKLKVMENFIYES 363
            .:....||.:..:.|.::|:::||:.:|.:..|...|:|.    ||....:|..:|.::.||.|:
  Fly   304 FMFEGHDTTTSGVGFAVYLLSRHPDEQEKLFNEQCDVMGASGLGRDATFQEISTMKHLDLFIKEA 368

Human   364 MRYQPVVDLVMRKALEDDVIDGYPVKKGTNIILNIGRM---HRLEFFPKPNEFTLENF--AKNVP 423
            .|..|.|..:.|...:|.||||..|.|||.  ||:|.:   :....|..|::|..|.|  .|..|
  Fly   369 QRLYPSVPFIGRFTEKDYVIDGDIVPKGTT--LNLGLLMLGYNDRVFKDPHKFQPERFDREKPGP 431

Human   424 YRYFQPFGFGPRGCAGKYIAMVMMKAILVTLLRRFHVKTLQGQCVESIQKIH-DLSLHPDETKN 486
            :.|. ||..|||.|.|:..|::.:|.::..::|.|.|.....:.|.....|. .|.|.|.|.|:
  Fly   432 FEYV-PFSAGPRNCIGQKFALLEIKTVVSKIIRNFEVLPALDELVSKDGYISTTLGLQPAEKKS 494

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CYP19A1	NP_000094.2	CYP19A1	72..485	CDD:410709	116/448 (26%)
Cyp4e1	NP_524771.1	p450	34..469	CDD:278495	121/469 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165154816
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24291
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.950