Protein Alignment CYP19A1 and Cyp4d20

DIOPT Version :9

• Sequence 1: NP_000094.2
• Gene: CYP19A1 / 1588
• HGNCID: 2594
• Length: 503
• Species: Homo sapiens
• Sequence 2: NP_647723.2
• Gene: Cyp4d20 / 38311
• FlyBaseID: FBgn0035344
• Length: 510
• Species: Drosophila melanogaster
• Alignment Length: 543
• Identity: 126/543 - (23%)
• Similarity: 217/543 - (39%)
• Gaps: 128/543 - (23%)

Human    26 MPVLLLTG--LFLLVWNYE---------GTSSIPGPGYCMGIGPLISHG-RFLWMG----IGSAC 74
            |.:.|:||  :.||.|::.         ..|:||||   :.| |::..| :.|.:|    ||...
  Fly     1 MWLTLITGALILLLTWDFGRKRQRVLAFEKSAIPGP---ISI-PILGCGLQALHLGAENIIGWVG 61

Human    75 NYYNRVYGEFMRVWISGEETLIISKSSSMFHIMKHNHYSSRFGSKLGLQCIGMHEKGIIFN---- 135
            ..::: ||:..|.||.| |:||.:|....|..:              |....:.|||.::.
  Fly    62 EKFDK-YGKTFRFWILG-ESLIYTKDLQYFETI--------------LSSTTLLEKGQLYEYLRP 110

Human   136 --------NNPELWKTTRPFFMKALSGPGLVRMVTVCAESLKTHLDRLEEVTNESGYVDVLTLLR 192
                    :....|...|..|..|.....|...|.:........:|.|.:|.:....||:|..:.
  Fly   111 FLNDGLLVSTGRKWHARRKIFTHAFHFKVLEHYVEIMDRHSSVMVDNLRKVADGKTAVDMLKYVS 175

Human   193 RVMLDTSNTLFLRIPLDESAIVVKIQG-------YFDAWQALL-IKPDIFFKIS----WLY---- 241
            ...||.         :.|:|:.|::..       |..|.:::: |:||..|:.|    ||:
  Fly   176 LAALDV---------ITEAAMGVQVNAQNDPDFPYIKALKSVVYIQPDRMFRFSRRYNWLFPLAA 231

Human   242 ----KKYEKSVKDLKDAIEVLIAEKRRRIST-------------EEKLEECMDFATELILAEKR- 288
                ::....::.:.|..:.:|:|:|..:..             :.::......|...||.:..
  Fly   232 PLLHRQLLSDIRVMHDFTDKVISERRETVRRAKADGTYRPLSLGDAEIGSKSQMALLDILLQSSI 296

Human   289 -------GDLTRENVNQCILEMLIAAPDTMSVSLFFMLFLIAKHPNVEEAIIKEIQTVIG---ER 343
                   .|: ||.|:..:.|    ..||.|..:...|:.||:||.|::.|.:|:|.|:|   ..
  Fly   297 NNQPLSDADI-REEVDTFMFE----GDDTTSSGVSHALYAIARHPEVQQRIFEELQRVLGPDASA 356

Human   344 DIKIDDIQKLKVMENFIYESMRYQPVVDLVMRKALEDDVIDGYPVKKGTNIILNIGRMHR-LEFF 407
            .:....:|.||.::..|.|:||..|.|..:.|.|.::..|....:...|:|.|.:...|| ..:|
  Fly   357 PVTQAQLQDLKYLDCVIKETMRLYPPVPAIGRHAQKELEIGDKTIPANTSIYLVLYYAHRDANYF 421

Human   408 PKPNEFTLENFAKNVPYRY----FQPFGFGPRGCAGKYIAMVMMKAILVTLLRRFHVKTLQGQCV 468
            |.|..|..|.|.::....:    :.||..||:.|.|:..|::.||.::..:||.:.:..|
  Fly   422 PDPLSFRPERFLEDQEQGHNTFAYVPFSAGPKNCIGQKFAVLEMKVLISKVLRFYELLPL----- 481

Human   469 ESIQKIHDLSLHPDETKNMLEMI 491
                        .:|.|.||..|
  Fly   482 ------------GEELKPMLNFI 492

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CYP19A1	NP_000094.2	CYP19A1	72..485	CDD:410709	103/473 (22%)
Cyp4d20	NP_647723.2	p450	34..493	CDD:278495	117/510 (23%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165154817
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24291
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.950