DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CYP19A1 and Cyp4aa1

DIOPT Version :9

Sequence 1:	NP_000094.2	Gene:	CYP19A1 / 1588	HGNCID:	2594	Length:	503	Species:	Homo sapiens
Sequence 2:	NP_611067.2	Gene:	Cyp4aa1 / 36752	FlyBaseID:	FBgn0034053	Length:	510	Species:	Drosophila melanogaster

Alignment Length:	474	Identity:	113/474 - (23%)
Similarity:	199/474 - (41%)	Gaps:	80/474 - (16%)

- Green bases have known domain annotations that are detailed below.

Human    36 LLVWNYEGTSSIPGPGYCMGIGPLISHGRFLWMGIGSACNYYNRVYGEFMRVWI---------SG 91
            ||.....|..|:|..|.||    |::....:....|.|.:    :||..:|:|:         ..
  Fly    43 LLSLRLTGPPSLPFLGNCM----LVTDKDLMRRCAGKAFD----LYGSLVRIWVLLFPFFAVLEP 99

Human    92 EETLIISKSSS-----MFHIMKHNHYSSRFGSKLGLQCIGMHEKGIIFNNNPELWKTTRPFFMKA 151
            |:..:|..|..     .|:.:.||.        ||        .|:|.::..: |...|.....|
  Fly   100 EDLQVILSSKKHTNKVFFYRLMHNF--------LG--------DGLITSSGSK-WSNHRRLIQPA 147

Human   152 LSGPGLVRMVTV---CAESLKTHLDRLEEVTNESGYVDVLTLLRRVMLDTSNTLFLRIPLDESAI 213
            .....|.:.:..   .::||..:|| .|.|..|   :::...:...:||..|...|.:|:.:...
  Fly   148 FHHNLLEKFIDTFVDASQSLYENLD-AEAVGTE---INIAKYVNNCVLDILNEAVLGVPIKKRGQ 208

Human   214 VVKIQGYFDAWQALLIKPDIFFKISWL----YKKYEKSVKD-------LKDAIEVLIAEKRRRI- 266
            .|.:.......|..::.|..|.: .||    ...:.|...|       |.|....:| ::||:|
  Fly   209 DVAMMEDSPFRQGKIMMPARFTQ-PWLLLDGIYHWTKMANDELNQKKRLNDFTRKMI-QRRRQIQ 271

Human   267 -----STEEKLEEC-MDFATELILAEKRGDLTRENVNQCILEMLIAAPDTMSVSLFFMLFLIAKH 325
                 ::|.|   | :|...|  ::|...|.|.|::.......::|..|::..::.|.|||:.::
  Fly   272 NNNNGNSERK---CLLDHMIE--ISESNRDFTEEDIVNEACTFMLAGQDSVGAAVAFTLFLLTQN 331

Human   326 PNVEEAIIKEIQTVI--GERDIKIDDIQKLKVMENFIYESMRYQPVVDLVMRKALEDDVIDGYPV 388
            |..::..:.|:.|:.  ..|...:.|:.:::.||..|.|::|..|.|.|:.||..|:..:..:.:
  Fly   332 PECQDRCVLELATIFEDSNRAPTMTDLHEMRYMEMCIKEALRLYPSVPLIARKLGEEVRLAKHTL 396

Human   389 KKGTNIILNIGRMHRL-EFFPKPNEFTLENFA-----KNVPYRYFQPFGFGPRGCAGKYIAMVMM 447
            ..|:|:.:.....||| ..:|.|.:|..|.|:     ...||. |.||..|||.|.|...|::.:
  Fly   397 PAGSNVFICPYATHRLAHIYPDPEKFQPERFSPENSENRHPYA-FLPFSAGPRYCIGNRFAIMEI 460

Human   448 KAILVTLLRRFHVKTLQGQ 466
            |.|:..|||.:.:..:.|:
  Fly   461 KTIVSRLLRSYQLLPVTGK 479

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CYP19A1	NP_000094.2	CYP19A1	72..485	CDD:410709	103/438 (24%)
Cyp4aa1	NP_611067.2	p450	50..475	CDD:278495	110/461 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165154694
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24291
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.950