Protein Alignment CYP19A1 and Cyp4aa1

DIOPT Version :10

• Sequence 1: NP_000094.2
• Gene: CYP19A1 / 1588
• HGNCID: 2594
• Length: 503
• Species: Homo sapiens
• Sequence 2: NP_611067.2
• Gene: Cyp4aa1 / 36752
• FlyBaseID: FBgn0034053
• Length: 510
• Species: Drosophila melanogaster
• Alignment Length: 474
• Identity: 113/474 - (23%)
• Similarity: 199/474 - (41%)
• Gaps: 80/474 - (16%)

Human    36 LLVWNYEGTSSIPGPGYCMGIGPLISHGRFLWMGIGSACNYYNRVYGEFMRVWI---------SG 91
            ||.....|..|:|..|.||    |::....:....|.|.:    :||..:|:|:         ..
  Fly    43 LLSLRLTGPPSLPFLGNCM----LVTDKDLMRRCAGKAFD----LYGSLVRIWVLLFPFFAVLEP 99

Human    92 EETLIISKSSS-----MFHIMKHNHYSSRFGSKLGLQCIGMHEKGIIFNNNPELWKTTRPFFMKA 151
            |:..:|..|..     .|:.:.||.        ||        .|:|.::..: |...|.....|
  Fly   100 EDLQVILSSKKHTNKVFFYRLMHNF--------LG--------DGLITSSGSK-WSNHRRLIQPA 147

Human   152 LSGPGLVRMVTV---CAESLKTHLDRLEEVTNESGYVDVLTLLRRVMLDTSNTLFLRIPLDESAI 213
            .....|.:.:..   .::||..:|| .|.|..|   :::...:...:||..|...|.:|:.:...
  Fly   148 FHHNLLEKFIDTFVDASQSLYENLD-AEAVGTE---INIAKYVNNCVLDILNEAVLGVPIKKRGQ 208

Human   214 VVKIQGYFDAWQALLIKPDIFFKISWL----YKKYEKSVKD-------LKDAIEVLIAEKRRRI- 266
            .|.:.......|..::.|..|.: .||    ...:.|...|       |.|....:| ::||:|
  Fly   209 DVAMMEDSPFRQGKIMMPARFTQ-PWLLLDGIYHWTKMANDELNQKKRLNDFTRKMI-QRRRQIQ 271

Human   267 -----STEEKLEEC-MDFATELILAEKRGDLTRENVNQCILEMLIAAPDTMSVSLFFMLFLIAKH 325
                 ::|.|   | :|...|  ::|...|.|.|::.......::|..|::..::.|.|||:.::
  Fly   272 NNNNGNSERK---CLLDHMIE--ISESNRDFTEEDIVNEACTFMLAGQDSVGAAVAFTLFLLTQN 331

Human   326 PNVEEAIIKEIQTVI--GERDIKIDDIQKLKVMENFIYESMRYQPVVDLVMRKALEDDVIDGYPV 388
            |..::..:.|:.|:.  ..|...:.|:.:::.||..|.|::|..|.|.|:.||..|:..:..:.:
  Fly   332 PECQDRCVLELATIFEDSNRAPTMTDLHEMRYMEMCIKEALRLYPSVPLIARKLGEEVRLAKHTL 396

Human   389 KKGTNIILNIGRMHRL-EFFPKPNEFTLENFA-----KNVPYRYFQPFGFGPRGCAGKYIAMVMM 447
            ..|:|:.:.....||| ..:|.|.:|..|.|:     ...||. |.||..|||.|.|...|::.:
  Fly   397 PAGSNVFICPYATHRLAHIYPDPEKFQPERFSPENSENRHPYA-FLPFSAGPRYCIGNRFAIMEI 460

Human   448 KAILVTLLRRFHVKTLQGQ 466
            |.|:..|||.:.:..:.|:
  Fly   461 KTIVSRLLRSYQLLPVTGK 479

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CYP19A1	NP_000094.2	CYP19A1	72..485	CDD:410709	103/438 (24%)
Cyp4aa1	NP_611067.2	CYP4	81..498	CDD:410721	101/428 (24%)