Protein Alignment CYP19A1 and Cyp4p3

DIOPT Version :9

• Sequence 1: NP_000094.2
• Gene: CYP19A1 / 1588
• HGNCID: 2594
• Length: 503
• Species: Homo sapiens
• Sequence 2: NP_610473.1
• Gene: Cyp4p3 / 35948
• FlyBaseID: FBgn0033397
• Length: 515
• Species: Drosophila melanogaster
• Alignment Length: 357
• Identity: 96/357 - (26%)
• Similarity: 167/357 - (46%)
• Gaps: 58/357 - (16%)

Human   166 ESLKTHLDRLEEVT-NESGYVDVLTLLRRVMLDTSNTLFLRIPLDESAIVVKIQGYFDAWQALLI 229
            ||||.    ||:.. |:...:.:..::.|..|::.....:.:.|||.|  .|...|.:.::.:
  Fly   163 ESLKF----LEQFKGNDEAIISLNEVIPRFTLNSICETAMGVKLDEMA--EKGDRYRENFRQI-- 219

Human   230 KPDIFFK-----ISW---LYKKYEKSVKDLKDAIEV-------LIAEKRRRISTE---------- 269
             .:.|.:     :.|   |:|.:.:  ||...|::|       :||::|.:::.|
  Fly   220 -EECFIRRMSNPLLWSDTLFKMFAE--KDYASALDVVHGFSSEIIAKRRDQLNDEIDSRGNTQTA 281

Human   270 --EKLEECMDFA--TELILAEKRGDLTRENVNQCILEMLIAAPDTMSVSLFFMLFLIAKHPNVEE 330
              |.......||  ..||||||.|.:....:.:.:..::....||.|:.|.|.|..::.:|..:|
  Fly   282 EDELFTSKKRFAMLDTLILAEKDGLIDHIGICEEVDTLMFEGYDTTSIGLMFGLMNMSLYPEEQE 346

Human   331 AIIKEIQTVIGE--RDIKIDDIQKLKVMENFIYESMRYQPVVDLVMRKAL-EDDVIDGYPVKKGT 392
            ...:|||..|.:  ..:.|..:.|||.:|.||.|:||..|.|..:.|:.. |.::.:|..:.||:
  Fly   347 KCYQEIQANIDDELNILNIGQLNKLKNLEYFIKETMRLFPSVPAMGRETTRETELSNGLILPKGS 411

Human   393 NIILNIGRMHR-LEFFPKPNEFTLENF-AKNVPYRY---FQPFGFGPRGCAGKYIAMVMMKAILV 452
            .|.:::..:|| .|::..|.||..|.| .:|...|:   :.||..|.|.|.|:..||..||.::|
  Fly   412 QIFVHVFDIHRNPEYWDSPEEFRPERFLPENSQNRHTYAYIPFSAGQRNCIGQKFAMQEMKTLMV 476

Human   453 TLLRRFHV------KTL---QGQCVESIQKIH 475
            .||::|.:      ||:   .|..:.:..:||
  Fly   477 ALLKQFQILPEIDPKTIVFQTGLTLRTKNQIH 508

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CYP19A1	NP_000094.2	CYP19A1	72..485	CDD:410709	96/357 (27%)
Cyp4p3	NP_610473.1	p450	54..505	CDD:278495	94/352 (27%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165154886
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24291
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	3.040