Protein Alignment CYP19A1 and Cyp4p2

DIOPT Version :9

• Sequence 1: NP_000094.2
• Gene: CYP19A1 / 1588
• HGNCID: 2594
• Length: 503
• Species: Homo sapiens
• Sequence 2: NP_610472.1
• Gene: Cyp4p2 / 35946
• FlyBaseID: FBgn0033395
• Length: 520
• Species: Drosophila melanogaster
• Alignment Length: 438
• Identity: 113/438 - (25%)
• Similarity: 193/438 - (44%)
• Gaps: 99/438 - (22%)

Human    90 SGEETLIISKSSSMFHIM-KHNHYSSRFGSKLGLQCIGMHEKGIIFN-NNPEL-----------W 141
            ||:..|..|...|.|::: .||..:.       |....:..||:|:| .:|.|           |
  Fly    82 SGDSYLQYSMGFSNFNVIDAHNAANI-------LNHPNLITKGVIYNFLHPFLRTGVLTATEKKW 139

Human   142 KT-----TRPFFMKALSGPGLVRMVTVCAESLKTHLDRLEEVTNESGYVDVLTLLR-RVMLDTSN 200
            .|     ||.|.:..|:   ..:.:.: |||||.       |:...|..:|:..|: |:...|.|
  Fly   140 HTRRSMLTRTFHLDILN---QFQEIFI-AESLKF-------VSQFQGQNEVVVSLKDRISRFTLN 193

Human   201 TL---FLRIPLDESAIVVKIQGYFDAWQA-----------LLIKPDIFFKISW---LYK-----K 243
            ::   .:.|.|||.|    .:|  |.::|           .::.|     :.|   :|.     |
  Fly   194 SICETAMGIKLDEMA----EKG--DRYRANFHIIDEGLTRRIVNP-----LYWDDCVYNMFTGHK 247

Human   244 YEKSVKDLKDAIEVLIAEKRRRISTEEKLEE-----------CM----DFA--TELILAEKRGDL 291
            |..::|.:.:....:||  :||:..||:||.           |:    .||  ..||.|||.|.:
  Fly   248 YNAALKVVHEFSREIIA--KRRVLLEEELENRRATQTADDDICVIRKKRFAMLDTLICAEKDGLI 310

Human   292 TRENVNQCILEMLIAAPDTMSVSLFFMLFLIAKHPNVEEAIIKEIQTVIGE--RDIKIDDIQKLK 354
            ....:::.:..::....||.|:.|.|.|..::.:...:|...:|||..|.:  .::.:..:.||.
  Fly   311 DDIGISEEVDTLMAEGYDTTSIGLVFGLMNMSLYAAEQELCYQEIQEHILDDLSNLNLSQLSKLN 375

Human   355 VMENFIYESMRYQPVVDLVMRKAL-EDDVIDGYPVKKGTNIILNIGRMHR-LEFFPKPNEFTLEN 417
            .:..||.|:||..|.:.::.|:.| |.::.:|..:.|.:.|.:::..:|| .:::..|.||..|.
  Fly   376 YLGYFIKETMRLYPSIPIMGRQTLQETELENGLILPKRSQINIHVFDIHRNPKYWESPEEFRPER 440

Human   418 F-----AKNVPYRYFQPFGFGPRGCAGKYIAMVMMKAILVTLLRRFHV 460
            |     .|..||.|. ||..|.|.|.|:..||..||.::|.:|:.|.:
  Fly   441 FLPQNCLKRHPYAYI-PFSAGQRNCIGQKYAMQEMKTLMVVILKHFKI 487

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CYP19A1	NP_000094.2	CYP19A1	72..485	CDD:410709	113/438 (26%)
Cyp4p2	NP_610472.1	p450	63..514	CDD:299894	113/438 (26%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165154888
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24291
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	3.040