DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CYP19A1 and Cyp4e2

DIOPT Version :9

Sequence 1:	NP_000094.2	Gene:	CYP19A1 / 1588	HGNCID:	2594	Length:	503	Species:	Homo sapiens
Sequence 2:	NP_001286196.1	Gene:	Cyp4e2 / 35822	FlyBaseID:	FBgn0014469	Length:	526	Species:	Drosophila melanogaster

Alignment Length:	506	Identity:	122/506 - (24%)
Similarity:	216/506 - (42%)	Gaps:	120/506 - (23%)

- Green bases have known domain annotations that are detailed below.

Human    26 MPVLLLTGLFLLVW-------NYEGTSSIP--GPGYCMGIGP------LIS----HGR---FLWM 68
            :|:||:..|.|..:       .:.|...:|  |..:.||..|      :.|    :|:   ..|:
  Fly    11 LPLLLVAYLELSTFRRRRVLNKFNGPRGLPLMGNAHQMGKNPSEILDTVFSWWHQYGKDNFVFWI 75

Human    69 GIGSACNYYNRVYGEFMRVWISGEETLI-----------------ISKSSSMFHIMKHN------ 110
            |..|.....:..|.||    |...:|||                 ::.:.|.:|  ||.
  Fly    76 GTYSNVLVTSSKYLEF----ILSSQTLITKSDIYQLTHPWLGLGLLTSTGSKWH--KHRKMITPA 134

Human   111 -HYSSRFGSKLGLQCIGMHEKGIIFNNNPELWKTTRPFFMKALSGPGLVRMVTVCAESLKTHLDR 174
             |::.       ||  ..||   :.|.|     :|:  |:|.|.        ||.|.      |.
  Fly   135 FHFNI-------LQ--DFHE---VMNEN-----STK--FIKHLK--------TVAAG------DN 166

Human   175 LEEVTNESGYVDVLTLLRRVMLDTSNTLFLRIPLDESAIVVKIQGYFDAWQAL-------LIKPD 232
            :.:...::.|   |||  .|:.||:..:.:....:.|:.:|  |.:.|....:       |.:.:
  Fly   167 IFDFQEQAHY---LTL--DVICDTAMGVSINAMENRSSSIV--QAFKDMCYNINMRAFHPLKRNE 224

Human   233 IFFKISWLYKKYEKSVKDLKDAIEVLIAE-----KRRRIST---EEKLEECMDFATELILAEKRG 289
            :.::::..|..|.:::|.|:|....:||:     |...:||   :|...:.|.|...|:.:...|
  Fly   225 LLYRLAPDYPAYSRTLKTLQDFTNEIIAKRIEAHKSGAVSTNAGDEFTRKKMAFLDTLLSSTIDG 289

Human   290 -DLTRENVNQCILEMLIAAPDTMSVSLFFMLFLIAKHPNVEEAIIKEIQTVIGE----RDIKIDD 349
             .|..:.:.:.:...:....||.:..:.|.::|:::|.:.:..:.||.:.|:|.    ||....:
  Fly   290 RPLNSKELYEEVSTFMFEGHDTTTSGVSFAVYLLSRHQDEQRKLFKEQREVMGNSELGRDATFQE 354

Human   350 IQKLKVMENFIYESMRYQPVVDLVMRKALEDDVIDGYPVKKGTNIILNIGRM---HRLEFFPKPN 411
            |.::|.::.||.|:.|..|.|..:.|...:|.||||..|.|||.  ||:|.:   :..:.|..|:
  Fly   355 ISQMKYLDLFIKEAQRVYPSVPFIGRFTEKDYVIDGDLVPKGTT--LNLGLVMLGYNEKVFKDPH 417

Human   412 EFTLENF--AKNVPYRYFQPFGFGPRGCAGKYIAMVMMKAILVTLLRRFHV 460
            :|..|.|  .|..|:.|. ||..|||.|.|:..|::.:|.::..::|.|.|
  Fly   418 KFRPERFELEKPGPFEYV-PFSAGPRNCIGQKFALLEIKTVVSKIIRNFEV 467

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CYP19A1	NP_000094.2	CYP19A1	72..485	CDD:410709	107/438 (24%)
Cyp4e2	NP_001286196.1	p450	35..469	CDD:278495	117/482 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165154815
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24291
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.950