Protein Alignment CYP19A1 and Cyp4d21

DIOPT Version :9

• Sequence 1: NP_000094.2
• Gene: CYP19A1 / 1588
• HGNCID: 2594
• Length: 503
• Species: Homo sapiens
• Sequence 2: NP_609129.2
• Gene: Cyp4d21 / 34036
• FlyBaseID: FBgn0031925
• Length: 511
• Species: Drosophila melanogaster
• Alignment Length: 512
• Identity: 111/512 - (21%)
• Similarity: 204/512 - (39%)
• Gaps: 114/512 - (22%)

Human    28 VLLLTGLFLLVW---------NYEGTSSIPGPGYCMGIGPLISHG-------------RFLWMGI 70
            ||::|    |||         |....|.|.||...    |::.:|             ||
  Fly     9 VLIMT----LVWDNSRKQWRVNTFEKSRILGPFTI----PIVGNGLQALTLRPENFIQRF----- 60

Human    71 GSACNYYNRVYGEFMRVWISGEETLIISKSSSMFH-------IMKHNHYSSRFGSKLGLQCIGMH 128
               .:|:|: ||:..|:||.| |.||.:|....|.       ::|..|........||
  Fly    61 ---GDYFNK-YGKTFRLWILG-ECLIYTKDLKYFESILSSSTLLKKAHLYRFLRDFLG------- 113

Human   129 EKGIIFNNNPELWKTTRPFFMKALSGPGLVRMVTVCAESLKTHLDRLEEVTNESGYVDVLTLLRR 193
             .|::.:...: |.:.|.....|.....|...|.:...:....:::|:...:....||:...:..
  Fly   114 -DGLLLSTGNK-WTSRRKVLAPAFHFKCLENFVEIMDRNSGIMVEKLKNYADGKTCVDLFKFVSL 176

Human   194 VMLDTSNTLFLRIPLDESAIVVKIQG-------YFDAWQALLI-----KPDIFFKISWL------ 240
            ..||.:.         |:|:.|::..       |..|.::::.     ...:..:.:||
  Fly   177 EALDVTT---------ETAMGVQVNAQNEPNFPYTKALKSVVYIESKRLASVSMRYNWLFPLAAP 232

Human   241 --YKKYEKSVKDLKDAIEVLIAEKR------RRISTEEKL------------EECMDFATELILA 285
              |::.:|.:..::|..:.:|.|:|      |...|.:.|            ...:|...:..:.
  Fly   233 LVYRRLQKDIAIMQDFTDKVIRERRAILERARADGTYKPLIMGDDDIGGKAKMTLLDILLQATID 297

Human   286 EKRGDLTRENVNQCILEMLIAAPDTMSVSLFFMLFLIAKHPNVEEAIIKEIQTVIG---ERDIKI 347
            .|  .|:..::.:.:...:.|..||.:..:...|..|::||.|:|.|.:|:.:|:|   :..:..
  Fly   298 NK--PLSDVDIREEVDVFIFAGDDTTTSGVSHALHAISRHPKVQECIYEELVSVLGPDPDASVTQ 360

Human   348 DDIQKLKVMENFIYESMRYQPVVDLVMRKALEDDVIDGYPVKKGTNIILNIGRMHR-LEFFPKPN 411
            ..:.:||.::..|.|:||..|.|.::.|...||..|....:...|:|:|....::| .|:||.|.
  Fly   361 TKLLELKYLDCVIKETMRLHPPVPILGRYIPEDLKIGEITIPGNTSILLMPYYVYRDPEYFPDPL 425

Human   412 EFTLENF-----AKNVPYRYFQPFGFGPRGCAGKYIAMVMMKAILVTLLRRFHVKTL 463
            .|..|.:     ..|.|...:.||..||:.|.|:..|.:.|||::..::|.:.:..|
  Fly   426 VFKPERWMDMKTTSNTPPLAYIPFSSGPKNCIGQKFANLQMKALISKVIRHYELLPL 482

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CYP19A1	NP_000094.2	CYP19A1	72..485	CDD:410709	96/446 (22%)
Cyp4d21	NP_609129.2	p450	35..482	CDD:278495	101/480 (21%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165154811
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24291
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.940