DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CYP19A1 and Cyp4ac3

DIOPT Version :9

Sequence 1:	NP_000094.2	Gene:	CYP19A1 / 1588	HGNCID:	2594	Length:	503	Species:	Homo sapiens
Sequence 2:	NP_608918.1	Gene:	Cyp4ac3 / 33756	FlyBaseID:	FBgn0031695	Length:	509	Species:	Drosophila melanogaster

Alignment Length:	523	Identity:	119/523 - (22%)
Similarity:	210/523 - (40%)	Gaps:	105/523 - (20%)

- Green bases have known domain annotations that are detailed below.

Human     1 MVLEMLNPIHYNITSIVPEAMPAATMP----VLLLTG-------LFLL------VWNY--EGTSS 46
            ::|..||..:: |.|:......|...|    |.::.|       |.||      :::|  |.|:.
  Fly    17 LLLRQLNKTYF-ILSLCKRVRTADGSPLESKVFVVPGKTRFGNNLDLLNLTPANIFSYIRESTAK 80

Human    47 IPGPGYCMGIGPLISHGRFLWMGIGSACNY-----YNRVYGEFMRVWISGEE----TLIISKSSS 102
            ..|..|             :|       |:     ||.|..|      ..||    |.|.:|:
  Fly    81 ANGQNY-------------IW-------NFLFAPEYNIVRAE------DAEEIFQSTKITTKN-- 117

Human   103 MFHIMKHNHYSSRFGSKLGLQCIGMHEKGIIFNNNPELWKTTRPFFMKALSGPGLVRMVTVCAES 167
                |.:.......|..|   .|.:.:|          |.|.|.....|.....|...:::..|.
  Fly   118 ----MSYELIRPFLGDGL---LISIDQK----------WHTRRKTLTPAFHFNILQSFLSIFKEE 165

Human   168 LKTHLDRLEEVTNESGYVDVLTLLRRVMLDTSNTLFLRIPLDE----SAIVVKIQGYFDAWQALL 228
            .|..:..|::  |....:::..::.:..|:......|.:.||:    :.....|..:...:...:
  Fly   166 SKKFIKILDK--NVGFELELNQIIPQFTLNNICETALGVKLDDMSEGNEYRKAIHDFEIVFNQRM 228

Human   229 IKPDIFFKISWL------YKKYEKSVKDLKDAIEVLIAEKRRRISTEEKLEECMDFATE------ 281
            ..|.:||  :|.      ||||.:.::.:......:|..||::.. :::|.:..:|..:
  Fly   229 CNPLMFF--NWYFFLFGDYKKYSRILRTIHGFSSGIIQRKRQQFK-QKQLGQVDEFGKKQRYAML 290

Human   282 --LILAEKRGDLTRENVNQCILEMLIAAPDTMSVSLFFMLFLIAKHPNVEEAIIKEIQTVIGERD 344
              |:.||..|.:..:.:...:...:....||.|.||.|.|.|:|.|.:|:|...:|:|.:..:.|
  Fly   291 DTLLAAEAEGKIDHQGICDEVNTFMFGGYDTTSTSLIFTLLLLALHADVQERCYEELQDLPEDID 355

Human   345 -IKIDDIQKLKVMENFIYESMRYQPVVDLVMRKALEDDVIDGYPVKKGTNIILNI-GRMHRLEFF 407
             :.:....:|..:|..|.||:|..|...::.|..:|:.|::|..:.|...|.::| ..|.....|
  Fly   356 EVSMFQFNELIHLECVIKESLRLFPSAPIIGRTCIEESVMNGLVLPKNAQISIHIYDIMRDARHF 420

Human   408 PKPNEFTLENF-AKNVPYRY---FQPFGFGPRGCAGKYIAMVMMKAILVTLLRRFHVKTLQGQCV 468
            ||||:|..|.| .:|...|:   |.||..|||.|.|:...::.:|.:|..::|.|  |.|....:
  Fly   421 PKPNQFLPERFLPENSVNRHPFAFVPFSAGPRNCIGQKFGVLEIKVLLAAVIRNF--KLLPATQL 483

Human   469 ESI 471
            |.:
  Fly   484 EDL 486

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CYP19A1	NP_000094.2	CYP19A1	72..485	CDD:410709	101/433 (23%)
Cyp4ac3	NP_608918.1	p450	51..504	CDD:278495	111/488 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165154885
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24291
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.950