Protein Alignment CYP19A1 and Cyp4ac2

DIOPT Version :9

• Sequence 1: NP_000094.2
• Gene: CYP19A1 / 1588
• HGNCID: 2594
• Length: 503
• Species: Homo sapiens
• Sequence 2: NP_608917.3
• Gene: Cyp4ac2 / 33755
• FlyBaseID: FBgn0031694
• Length: 511
• Species: Drosophila melanogaster
• Alignment Length: 429
• Identity: 108/429 - (25%)
• Similarity: 190/429 - (44%)
• Gaps: 65/429 - (15%)

Human    63 GR-FLWMGIGSACNYYNRVYGEFMRVWISGEETLIISK---SSSMFHIMKHNHYSSRFGSKLGLQ 123
            || :||....:.  .||.|..|      ..||.|..||   .:.::.::|         ..||
  Fly    84 GRNYLWYFFHAP--MYNIVRAE------EAEEILQSSKLITKNMIYELLK---------PFLG-- 129

Human   124 CIGMHEKGIIFNNNPELWKTTRPFFMKALSGPGLVRMVTVCAESLKTHLDRLEEVTNESGYVDVL 188
                  :|::.:.: :.|.:.|    |||:.....:::.......|...::|.:|.::|  |::.
  Fly   130 ------EGLLISTD-QKWHSRR----KALTPAFHFKVLQSFLIIFKEECNKLVKVLHQS--VNME 181

Human   189 TLLRRVM----LDTSNTLFLRIPLDESAIVVK----IQGYFDAWQALLIKPDIFFKISW--LYKK 243
            ..|.:|:    |:......|.:.||:.:..::    |....:..|..|..| .|:.|.:  |:..
  Fly   182 LELNQVIPQFTLNNVCETALGVKLDDLSEGIRYRQSIHAIEEVMQQRLCNP-FFYNIVYFFLFGD 245

Human   244 YEKSVKDLKDAIEVL--IAEKRRRISTEEKLEECMDFATE--------LILAEKRGDLTRENVNQ 298
            |.|.|.:||.|.|..  |.||||.:....:|.:..:|..:        |:.||..|.:..:.:..
  Fly   246 YRKQVNNLKIAHEFSSNIIEKRRSLFKSNQLGQEDEFGKKQRYAMLDTLLAAEADGQIDHQGICD 310

Human   299 CILEMLIAAPDTMSVSLFFMLFLIAKHPNVEEAIIKEIQTVIGER-DIKIDDIQKLKVMENFIYE 362
            .:...:....||.|..|.|.|.::|.|.:|::...:||:.:..:. ||.:....:|..||..|.|
  Fly   311 EVNTFMFEGYDTTSTCLIFTLLMLALHEDVQKKCYEEIKYLPDDSDDISVFQFNELVYMECVIKE 375

Human   363 SMRYQPVVDLVMRKALEDDVIDGYPVKKGTNIILNIGRMHR-LEFF--PK---PNEFTLENFAKN 421
            |:|..|.|..:.|:.:|:.|::|..:.|.|.|.:::..:.| ...|  ||   |:.|..||....
  Fly   376 SLRLFPSVPFIGRRCVEEGVVNGLIMPKNTQINIHLYEIMRDARHFSNPKMFQPDRFFPENTVNR 440

Human   422 VPYRYFQPFGFGPRGCAGKYIAMVMMKAILVTLLRRFHV 460
            .|:. |.||..|.|.|.|:..|::.:|.:|..::|.|.:
  Fly   441 HPFA-FVPFSAGQRNCIGQKFAILEIKVLLAAVIRNFKI 478

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CYP19A1	NP_000094.2	CYP19A1	72..485	CDD:410709	104/419 (25%)
Cyp4ac2	NP_608917.3	p450	57..505	CDD:278495	108/429 (25%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165154884
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24291
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	3.040