Protein Alignment CYP19A1 and Cyp4s3

DIOPT Version :9

• Sequence 1: NP_000094.2
• Gene: CYP19A1 / 1588
• HGNCID: 2594
• Length: 503
• Species: Homo sapiens
• Sequence 2: NP_573003.2
• Gene: Cyp4s3 / 32444
• FlyBaseID: FBgn0030615
• Length: 495
• Species: Drosophila melanogaster
• Alignment Length: 497
• Identity: 114/497 - (22%)
• Similarity: 197/497 - (39%)
• Gaps: 137/497 - (27%)

Human    35 FLLVWNYEGTSSIPGPGYCMGIGPLISHGRFLWMGIGSACNYYNRV---YGEFMRVWISGEETLI 96
            ||.:..:..|  :|||    .||.||::     :..|...|:...:   :|...|:|...:..::
  Fly    25 FLRLQRFAKT--LPGP----TIGELIAN-----VKKGEILNWLKELREKHGPVFRIWFGKDLMVM 78

Human    97 ISKSSSMFHIMKHNHYSSRFGS-KLGLQCIGMHEKGIIFNNNPELWKTTRPFFMKALSGPG---- 156
            .:....:..::.:|...::..: :|....:|   ||:: .|..|.|...|    |.|: ||
  Fly    79 FTDPEDIKQLLGNNQLLTKSRNYELLEPWLG---KGLL-TNGGESWHRRR----KLLT-PGFHFR 134

Human   157 ---------------LVRMV---------------------TVC--AESLKTHLDRLEEVTNESG 183
                           |||.:                     .:|  |..:|.|    .::.::|.
  Fly   135 ILSEFKEPMEENCRILVRRLRTKANGESFDIYPYITLFALDAICETAMGIKKH----AQLQSDSE 195

Human   184 YVDVLTLLRRVMLDTSNTLFLRIPLDESAIVVKIQGYFDAWQALLIKPDIFFKISWLYKKYEKSV 248
            ||..:..:.|||...|                     |..||.|    ::||       |:.|..
  Fly   196 YVQAVQSICRVMHKQS---------------------FSFWQRL----NVFF-------KHTKPG 228

Human   249 KDLKDAIEVLIAEKRR--RISTEEKLEECMDFATE-----------------LILAEKRG--DLT 292
            |:.:.|::||..|..|  |:..|:.::|..::..|                 |:|.:..|  :|:
  Fly   229 KEREAALKVLHDETNRVIRLRREQLIQERNEWKPEAEQDDVGAKRRLAFLDMLLLTQMEGGAELS 293

Human   293 RENVNQCILEMLIAAPDTMSVSLFFMLFLIAKHPNVEEAIIKEIQTVIGERDIKIDDIQKLKVME 357
            ..::.:.:...:....||.|.::.|.|.|::|:|:|::...:|...:.|.      :.:.:..:|
  Fly   294 DTDIREEVDTFMFEGHDTTSSAIAFALSLLSKNPDVQQRAFEEASELEGR------EKESMPYLE 352

Human   358 NFIYESMRYQPVVDLVMRKALEDDVIDGYPVKKGTNIILNIGRMHR-LEFFPKPNEFTLENFAKN 421
            ..|.|::|..|.|....||.|||..:....|.||.:|...|..:|| .:.||.|..|..:.|..|
  Fly   353 AVIKETLRIYPSVPFFSRKVLEDLEVGKLTVPKGASISCLIYMLHRDPKNFPDPERFDPDRFLVN 417

Human   422 VPYRYFQPFGF-----GPRGCAGKYIAMVMMKAILVTLLRRF 458
              .:...||.|     |||.|.|:..||:.:|..|..|||.:
  Fly   418 --EKQMHPFAFAAFSAGPRNCIGQKFAMLELKTSLAMLLRSY 457

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CYP19A1	NP_000094.2	CYP19A1	72..485	CDD:410709	103/460 (22%)
Cyp4s3	NP_573003.2	p450	35..469	CDD:278495	111/485 (23%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165154693
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24291
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.950