DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment MOSPD2 and hpo-28

DIOPT Version :9

Sequence 1:	NP_689794.1	Gene:	MOSPD2 / 158747	HGNCID:	28381	Length:	518	Species:	Homo sapiens
Sequence 2:	NP_498232.3	Gene:	hpo-28 / 175798	WormBaseID:	WBGene00015148	Length:	567	Species:	Caenorhabditis elegans

Alignment Length:	554	Identity:	146/554 - (26%)
Similarity:	246/554 - (44%)	Gaps:	132/554 - (23%)

- Green bases have known domain annotations that are detailed below.

Human    29 SDKYDARDVERLQQDDNWVESYLSWRHNIVDETLKMLDESFQWRKEISVNDLNESSIPRWLLEIG 93
            |.|:.:.||.|::.:|.|::.:|...:..||....::.|..:||:...|:.::..|: :.||:..
Worm    41 SVKHLSDDVHRIRHEDWWLDRFLGSVNYDVDIAYAIMLECLKWRRNFEVDRISLLSL-KPLLDNQ 104

Human    94 VIYLHGYDKEGNKLFWIRV-KYHVKDQKTILDKKKLIAFWLER-YAKRENGKPVTVMFDLSETGI 156
            ::||||.|.:...:.||.: ||...|.    ..:||..||:|| |.:.:..:|:||..|::.||:
Worm   105 LMYLHGKDLQNRHMLWIMMNKYKNGDD----GFEKLFTFWIERHYMEYKGCQPLTVFIDMTGTGL 165

Human   157 NSIDMDFVRFIINCFKVYYPKYLSKIVIFDMPWLMNAAFKIVKTWLGPEAVS----LLKFTSKNE 217
            .::..|.::|||:..|.|||..:..|:||:.|.::||::|::.:||...|.|    ||.|.:|..
Worm   166 KNMSFDAMKFIIHSSKYYYPNSIESILIFENPAILNASWKVIGSWLESSAASQRHDLLTFVTKLS 230

Human   218 VQDYVSVEYLPPHMGGTDPFKYSY-----------PP------------LVDDDFQTPLCENGPI 259
            |..||...:|..|.||||.||::.           ||            .:||.      .|..:
Worm   231 VTHYVPKSHLLEHQGGTDTFKFTMDELAKCLPPPPPPKPSPKLLQQRMHSIDDS------TNNNV 289

Human   260 TSEDETS-SKEDIESDGKETLETISNEEQTPLLKKINPTESTSKAEENEK----------VDSKV 313
            |..|.:| .|.:::.|.:.|      .::.|.|.:     .:|:..::.|          ::::|
Worm   290 TEFDFSSFQKRNVKFDEEST------TKRAPSLSR-----RSSRGPKSRKSHIPPSLRPLIENRV 343

Human   314 KAFKKPLSVFKGPLLHISPAEELYFGSTESGEKKTLIVLTNVTKN-----IVAFKVRTTAPEKYR 373
            .|.....|  ....:.|:|.:||.....: ||...|.|:  :.||     .:.||.:||:|||:|
Worm   344 NAPSDDWS--SNDFVSITPRDELRLEKLD-GENDLLDVV--LVKNQSSDTPIMFKFKTTSPEKFR 403

Human   374 VKPSNSSCDPGASVDIVVSPHGGLTVS-AQDRFLIMAAEMEQSSGTGPAELTQFWKEVPRNKVME 437
            |:||:....||.:..|.|........| .:::||::..|   ||.|.....::.:|.. .||. |
Worm   404 VRPSSGIVQPGTTEIIRVYLQYEYRHSWNKEKFLLLTME---SSSTDVESFSEQFKSA-SNKA-E 463

Human   438 HRLRCHTVESSKPNTLTLKDNAFNMSDKTSEDICLQLSRLLESNRKLEDQVQRCIWF---QQLLL 499
            .:.:|.                                  |..|.||:...:|...|   ||.||
Worm   464 FKFKCR----------------------------------LSENLKLDQPEERRSSFLLQQQQLL 494

Human   500 S----------------LTMLLLAF-VTSFFYLL 516
            |                :|::|..| :..|.|:|
Worm   495 SKPEGFSLGGFNIYLPIITLILFLFLIFQFSYIL 528

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MOSPD2	NP_689794.1	CRAL_TRIO	93..234	CDD:279044	52/146 (36%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	252..308		10/56 (18%)
		Motile_Sperm	327..431	CDD:279029	33/109 (30%)
hpo-28	NP_498232.3	SEC14	105..247	CDD:238099	52/145 (36%)
hpo-28	NP_498232.3	Motile_Sperm	<381..460	CDD:279029	25/82 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C161454676
Domainoid	1	1.000	99	1.000	Domainoid score	I4909
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H22125
Inparanoid	1	1.050	153	1.000	Inparanoid score	I3351
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG49365
OrthoDB	1	1.010	-	-		D217631at33208
OrthoFinder	1	1.000	-	-		FOG0002427
OrthoInspector	1	1.000	-	-		oto21869
orthoMCL	1	0.900	-	-		OOG6_101230
Panther	1	1.100	-	-	LDO	PTHR46384
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X5431
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	14	13.910