Protein Alignment ZXDB and zxdc

DIOPT Version :10

• Sequence 1: NP_009088.1
• Gene: ZXDB / 158586
• HGNCID: 13199
• Length: 803
• Species: Homo sapiens
• Sequence 2: XP_031757030.1
• Gene: zxdc / 100495694
• XenbaseID: XB-GENE-1033000
• Length: 869
• Species: Xenopus tropicalis
• Alignment Length: 784
• Identity: 407/784 - (51%)
• Similarity: 495/784 - (63%)
• Gaps: 89/784 - (11%)

Human    47 LRGP-----QDGGPGRRREEASTASRGPGPSLLAPRTDQPSGGGGGGGDDFFLVLLDPVGGDVET 106
            ::||     ||||||...:|.:..|....|                  |:
 Frog     3 IQGPADQPQQDGGPGIPAQEETKESLDESP------------------DE--------------- 34

Human   107 AGSGQAAGPVLREEAEEGPG----LQGGESGANPAGPTALGPRCLSAVPTPAPISAPGPAAAFAG 167
                :...|.|..|||:||.    |...|..|.||   ..|...| ..|:|:..|..|    ..|
 Frog    35 ----EEKQPGLVNEAEDGPPVYMVLNLSEEAAAPA---VTGEHDL-VRPSPSSSSELG----LPG 87

Human   168 TVTIHNQDLLLRFENGVLTLATPPPHAWEPGAAPAQQPGCLIAPQAGFPH----AAHPGDCPELP 228
            .||:       |.|||||||......:.||...|.......|..|..:..    |:..|.....|
 Frog    88 YVTV-------RLENGVLTLGGRGSESVEPAEPPVSNQVSDIQAQPAWASELEAASSSGAAQRFP 145

Human   229 PDLLLAEPAEPAPAPAPEEEAEGPAAALGPRGPLGSGPG----------VVLYLCPEAQCGQTFA 283
            .||   |..:.....:.:|:..|  ..:|..|.|....|          ::::.|||..|.:.|.
 Frog   146 EDL---EDVDLVLRDSMDEQVAG--FLVGEIGELQVNLGEALDLARKGVLLVFRCPEPGCAKAFD 205

Human   284 KKHQLKVHLLTHSSSQGQRPFKCPLGGCGWTFTTSYKLKRHLQSHDKLRPFGCPAEGCGKSFTTV 348
            :|.|||||||:|  ::|||||||.:..|||:|||.||||||||||||.|||.|...|||||||||
 Frog   206 RKQQLKVHLLSH--TEGQRPFKCTVANCGWSFTTLYKLKRHLQSHDKQRPFSCDVPGCGKSFTTV 268

Human   349 YNLKAHMKGHEQENSFKCEVCEESFPTQAKLSAHQRSHFEPERPYQCAFSGCKKTFITVSALFSH 413
            ||||||:|.|||||.|:|:.|.|||||..|||.|:|.||||||||:|.|.||.||||||:|||||
 Frog   269 YNLKAHLKAHEQENLFRCDTCGESFPTATKLSGHRRMHFEPERPYKCEFPGCDKTFITVTALFSH 333

Human   414 NRAHFREQELFSCSFPGCSKQYDKACRLKIHLRSHTGERPFLCDFDGCGWNFTSMSKLLRHKRKH 478
            :|||.||||.|.||||||:||||||||||||||||||||||:||||||||:||||||||||||||
 Frog   334 HRAHVREQEQFICSFPGCNKQYDKACRLKIHLRSHTGERPFICDFDGCGWSFTSMSKLLRHKRKH 398

Human   479 DDDRRFMCPVEGCGKSFTRAEHLKGHSITHLGTKPFVCPVAGCCARFSARSSLYIHSKKHLQDVD 543
            :||||:.|||||||||||||||||||||||||||||.||:.||.|:||||||||||||||||||:
 Frog   399 EDDRRYPCPVEGCGKSFTRAEHLKGHSITHLGTKPFECPIDGCGAKFSARSSLYIHSKKHLQDVE 463

Human   544 TWKSRCPISSCNKLFTSKHSMKTHMVKRHKVGQDLLAQLEAANSLTPSSELTSQRQNDLSDAEIV 608
            |.|:||.:.||||:||||.|||:||||:|....|||.||||::||||||||||..|||||:.::.
 Frog   464 TSKTRCLVPSCNKMFTSKQSMKSHMVKQHNFSPDLLTQLEASSSLTPSSELTSLGQNDLSNLDLS 528

Human   609 SLFSDVPDSTSAALLDTALVNSGILTIDVASVSSTLAGHLPANNNNSVGQAVDPPSLMATSDPPQ 673
            |||::|..:......|..|||||||||||:||.|||.|:|..||::.| ..|||..|::.|:..|
 Frog   529 SLFTNVSSNGPGISADLTLVNSGILTIDVSSVGSTLGGNLSVNNSSLV-HPVDPLVLVSNSETQQ 592

Human   674 SLDTSLFFGTAATGFQQSSLNMDEVSSVSVGPLGSLDSLAMKNSSPEPQALTPSSKLTVDTDALT 738
            ||::||..|.||:..||.:|.:|:|.:|:...||||.||:|:.||.:.|.||.|:.||:|: .||
 Frog   593 SLESSLLLGAAASILQQGTLQLDDVQTVNAEALGSLASLSMRGSSQDIQGLTSSNSLTIDS-TLT 656

Human   739 PSSTL-CENSVSELLTPTKAEWNVHPDSDFFG-QEGE---TQFGFPNAAGNHGSQKETDLITVTG 798
            ||.:| ..:||.|||||.|.:.::.|:.:..| |||.   |||.|.|..|::.:|||.|.....|
 Frog   657 PSVSLGASSSVPELLTPPKTDRSLIPNPEVVGEQEGSKVVTQFAFSNPTGSYSAQKEMDYSLTAG 721

Human   799 SSFL 802
            ||.|
 Frog   722 SSSL 725

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ZXDB	NP_009088.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..91		11/48 (23%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	120..140		10/23 (43%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	218..260		9/41 (22%)
		Required for interaction with ZXDC. /evidence=ECO:0000250	271..577		234/305 (77%)
		C2H2 Zn finger	273..295	CDD:275368	13/21 (62%)
		zf-C2H2	304..328	CDD:395048	17/23 (74%)
		C2H2 Zn finger	306..328	CDD:275368	15/21 (71%)
		C2H2 Zn finger	336..358	CDD:275368	17/21 (81%)
		COG5048	<344..539	CDD:227381	162/194 (84%)
		C2H2 Zn finger	366..386	CDD:275368	12/19 (63%)
		C2H2 Zn finger	395..417	CDD:275368	16/21 (76%)
		C2H2 Zn finger	429..448	CDD:275368	17/18 (94%)
		C2H2 Zn finger	456..478	CDD:275368	20/21 (95%)
		COG5048	466..>747	CDD:227381	177/281 (63%)
		C2H2 Zn finger	486..508	CDD:275368	21/21 (100%)
		C2H2 Zn finger	516..538	CDD:275370	17/21 (81%)
		Required for transcriptional activation. /evidence=ECO:0000250	576..703		67/126 (53%)
zxdc	XP_031757030.1	C2H2 Zn finger	195..217	CDD:275368	13/21 (62%)
		zf-C2H2	224..248	CDD:395048	17/23 (74%)
		C2H2 Zn finger	226..248	CDD:275368	15/21 (71%)
		zf-C2H2_8	256..333	CDD:464935	56/76 (74%)
		C2H2 Zn finger	256..278	CDD:275368	17/21 (81%)
		C2H2 Zn finger	286..306	CDD:275368	12/19 (63%)
		C2H2 Zn finger	315..337	CDD:275368	16/21 (76%)
		COG5048	<331..487	CDD:227381	132/155 (85%)
		C2H2 Zn finger	346..368	CDD:275368	20/21 (95%)
		C2H2 Zn finger	376..398	CDD:275368	20/21 (95%)
		C2H2 Zn finger	406..428	CDD:275368	21/21 (100%)
		C2H2 Zn finger	436..458	CDD:275368	17/21 (81%)
		C2H2 Zn finger	469..492	CDD:275371	16/22 (73%)