DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CYP11B2 and Cyp12a4

DIOPT Version :9

Sequence 1:	NP_000489.3	Gene:	CYP11B2 / 1585	HGNCID:	2592	Length:	503	Species:	Homo sapiens
Sequence 2:	NP_650783.2	Gene:	Cyp12a4 / 42294	FlyBaseID:	FBgn0038681	Length:	536	Species:	Drosophila melanogaster

Alignment Length:	536	Identity:	147/536 - (27%)
Similarity:	248/536 - (46%)	Gaps:	80/536 - (14%)

- Green bases have known domain annotations that are detailed below.

Human     5 AKAEVCVAAPWLSLQRARALGTRAARAPRTVLPFEAMPQHPGNRWLRLLQIWREQG-YEHLHL-E 67
            |.||....:.||..:                 |||.:|:.  |.|...:::....| |:::.| |
  Fly    31 ATAEAREDSEWLQAK-----------------PFEQIPRL--NMWALSMKMSMPGGKYKNMELME 76

Human    68 MHQTF-QELGPIFRYN--LGGPRMVCVMLPEDVEKLQQVDSLHPCR----MILEPWVAYRQ--HR 123
            |.:.. |:.|.||...  :|.|..:....|:|.|.:.:.:.:.|.|    .:|.....||:  ::
  Fly    77 MFEAMRQDYGDIFFMPGIMGNPPFLSTHNPQDFEVVFRNEGVWPNRPGNYTLLYHREEYRKDFYQ 141

Human   124 GHKCGVFLLNGPEWRFNRLRLNPDVLSPKAVQRFLPMVDAVARDFSQALKKKVLQNARGSLTL-- 186
            | ..||....|..|...|..:||.::.||.|:.:...:..|.::|.|    ::|: .|...||
  Fly   142 G-VMGVIPTQGKPWGDFRTVVNPVLMQPKNVRLYYKKMSQVNQEFVQ----RILE-LRDPDTLEA 200

Human   187 --DVQPSIFHYTIEASNLALFGERLGLVGHS-PSSASLNFLHALEVMFKSTVQLMFMPRSLSRWI 248
              |...:|..:|:|:.::....::|||:.:| ..|.:|...|.|:..|..::.|...| |..|:|
  Fly   201 PDDFIDTINRWTLESVSVVALDKQLGLLKNSNKESEALKLFHYLDEFFIVSIDLEMKP-SPWRYI 264

Human   249 SPKVWKEHFEAWDCI----FQYGDNCIQKIYQEL--AFNRPQHYTGIVAELLLKAELSLEAIKAN 307
            .....|....|.|.|    ..|.|..|:::.:|.  ...||::...:: |.|||.:..:..:.|
  Fly   265 KTPKLKRLMRALDGIQEVTLAYVDEAIERLDKEAKEGVVRPENEQSVL-EKLLKVDRKVATVMA- 327

Human   308 SMELTAGSVDTTAFPLLMTLFELARNPDVQQILRQESLAAAAS-ISEHPQKATTELPLLRAALKE 371
             |::....||||:......|..||:||:.|..||:|.:....: .||..:.:...:|.|||.:||
  Fly   328 -MDMLMAGVDTTSSTFTALLLCLAKNPEKQARLREEVMKVLPNKNSEFTEASMKNVPYLRACIKE 391

Human   372 TLRLYPVGLFLERVVSSDLVLQNYHIPAGTLVQVF-LYSLGRNAALFPRPERYNPQRWL------ 429
            :.||:|:.:...||::.|.||..|.:||||.|.:. |.:|.|: ..||:...:.|:|||
  Fly   392 SQRLHPLIVGNARVLARDAVLSGYRVPAGTYVNIVPLNALTRD-EYFPQASEFLPERWLRSPKDS 455

Human   430 -------DIRGSGRNFHHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHFLVE------------T 475
                   ::: |...|..:|||||.|.|:|:|:.|.|:.|....::::|.||            .
  Fly   456 ESKCPANELK-STNPFVFLPFGFGPRMCVGKRIVEMELELGTARLIRNFNVEFNYPTENAFRSAL 519

Human   476 LTQEDIKMVYSFILRP 491
            :...:|.:.:.||..|
  Fly   520 INLPNIPLKFKFIDLP 535

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CYP11B2	NP_000489.3	p450	42..454	CDD:365848	128/448 (29%)
Cyp12a4	NP_650783.2	p450	72..531	CDD:299894	131/470 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0159
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D185685at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820