Protein Alignment CYP11B2 and Cyp49a1

DIOPT Version :9

• Sequence 1: NP_000489.3
• Gene: CYP11B2 / 1585
• HGNCID: 2592
• Length: 503
• Species: Homo sapiens
• Sequence 2: NP_001246256.1
• Gene: Cyp49a1 / 36105
• FlyBaseID: FBgn0033524
• Length: 589
• Species: Drosophila melanogaster
• Alignment Length: 523
• Identity: 133/523 - (25%)
• Similarity: 240/523 - (45%)
• Gaps: 60/523 - (11%)

Human    21 ARALGTRAARAP-RTVLPFEAMP-QHP----GNRW--LRLLQIWREQGYEHLHLEMHQTFQELGP 77
            |.:|......:| ..|.|:..:| .:|    ||.|  ..|:..::....:.:..|:|..:.::..
  Fly    82 ASSLPAETTSSPAAAVRPYSEVPGPYPLPLIGNSWRFAPLIGTYKISDLDKVMNELHVNYGKMAK 146

Human    78 IFRYNLGGPRMVCVMLPEDVEKLQQVDSLHPCRMILEPWVAY-----RQHRGHKCGVFLLNGPEW 137
            :... :|.|.::.|...:::..:.:.:...|.|..:.....|     |...|...|:..::||:|
  Fly   147 VGGL-IGHPDLLFVFDGDEIRNIFKKEEAMPHRPSMPSLRHYKGDLRRDFFGDVAGLIGVHGPKW 210

Human   138 RFNRLRLNPDVLSPKAVQRFLPMVDAVARDFSQALKKKVLQNARGSLTLDVQPSIFHYTIEASNL 202
            ...|..:...:|.|:..::::|.::.:|.:|...:  :::::.:..|..:....::.:.:|:...
  Fly   211 EAFRQEVQHILLQPQTAKKYIPPLNDIASEFMGRI--ELMRDEKDELPANFLHELYKWALESVGR 273

Human   203 ALFGERLGLVGHSPSSASLNFLHALEVMFKSTVQL-MFMPRSLSRWISPKVWKEHFEAWDCIFQY 266
            .....|||.:....|..:...:.|:...|.:..:| :.||  |.|....|.::...:|.|   |:
  Fly   274 VSLDTRLGCLSPEGSEEAQQIIEAINTFFWAVPELELRMP--LWRIYPTKAYRSFVKALD---QF 333

Human   267 GDNCIQKIYQEL---------AFNRPQHYTGIVAELLLK-AELSLEAIKANSMELTAGSVDTTAF 321
            ...|::.|.:.:         ..::.:....||..::.| ....|.||.|  ::|....||||:.
  Fly   334 TAICMKNIGKTMDKADADEARGLSKSEADISIVERIVRKTGNRKLAAILA--LDLFLVGVDTTSV 396

Human   322 PLLMTLFELARNPDVQQILRQESLAAAASISEH-----PQKATTELPLLRAALKETLRLYPVGLF 381
            ....|:::||:|||.|:.|..|    ...:..|     .|....::|.|||.:|||||:.||.:.
  Fly   397 AASSTIYQLAKNPDKQKKLFDE----LQKVFPHREADINQNVLEQMPYLRACVKETLRMRPVVIA 457

Human   382 LERVVSSDLVLQNYHIPAGTLVQVFLYSLGRN-AALFPRPERYNPQRWL----DIRG---SGRNF 438
            ..|.:.||.|:..||:|.||.| :|.:.:..| .|.||.|:|:.|:|||    |..|   :.:..
  Fly   458 NGRSLQSDAVINGYHVPKGTHV-IFPHLVVSNDPAYFPEPKRFLPERWLKQSTDAAGCPHANQKI 521

Human   439 H---HVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHFLVETLTQEDIKMVYSFILRPGTSPL---L 497
            |   .:|||||.|.|:|||.||.|:..||..:.:.:.|...:.|.:..|.|..:  ..|||   |
  Fly   522 HPFVSLPFGFGRRMCVGRRFAEIELHTLLAKIFRKYKVSYNSGEFVYRVNSTYI--PQSPLNFKL 584

Human   498 TFR 500
            |.|
  Fly   585 TLR 587

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CYP11B2	NP_000489.3	p450	42..454	CDD:365848	111/450 (25%)
Cyp49a1	NP_001246256.1	p450	104..565	CDD:299894	119/475 (25%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0159
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D185685at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820