Protein Alignment PRUNE2 and RhoGAP68F

DIOPT Version :10

• Sequence 1: XP_006717045.1
• Gene: PRUNE2 / 158471
• HGNCID: 25209
• Length: 3104
• Species: Homo sapiens
• Sequence 2: NP_001401037.1
• Gene: RhoGAP68F / 39385
• FlyBaseID: FBgn0036257
• Length: 485
• Species: Drosophila melanogaster
• Alignment Length: 288
• Identity: 77/288 - (26%)
• Similarity: 124/288 - (43%)
• Gaps: 67/288 - (23%)

Human  2782 DMRPEPPNSL-DLNDTHPR----RIKLTAPNINLSLDQSEGS-ILSDDNLDSPDEIDINVDELDT 2840
            |...||..|| ||:|..|:    ..:|.||: .|..|...|. :|::|....|:| |:|..|
  Fly    30 DNSDEPQPSLSDLHDFEPKLEFDDTELLAPS-PLEKDVMVGDFVLAEDPELEPEE-DVNPLE--- 89

Human  2841 PDEADSFEYTGHEDPTANKDSGQESESIPEYTAEEEREDNRLWRTVVIGEQEQRIDMKVIEPYRR 2905
                |.||                         ::.||.:..::|                |..:
  Fly    90 ----DDFE-------------------------DQLREQSENFQT----------------PRNK 109

Human  2906 VISHGGDSGYYGDGLNAIIVFAACFLPDSSRADYHYVMENLFLYVISTLELMVAEDYMIVYLNGA 2970
            ....|.|.    .|.:...::|:.| |:.|:      :|.....:|..:|..|..||::||.:..
  Fly   110 CDFLGTDK----QGRHIFGIYASRF-PEKSQ------LEGFVREIIKEIEPFVENDYILVYFHQG 163

Human  2971 TPRRRMPGLGWMKKCYQMIDRRLRKNLKSFIIVHPSWFIRTILAVTRPFISSKFSSKIKYVNSLS 3035
            ......|...::...|:.:||..|||||:..:|||:||||.|.....||||.||..|:.|::||.
  Fly   164 LKEDNKPSAQFLWNSYKELDRNFRKNLKTLYVVHPTWFIRVIWNFFSPFISDKFRKKLVYISSLD 228

Human  3036 ELSGLIPMDCIHIPESIIKYDEERSYKR 3063
            ||...:.::.:.:|::|...|::.:..|
  Fly   229 ELRQALGLNKLKLPDNICDLDDKLNPSR 256

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PRUNE2	XP_006717045.1	DHHA2	221..>278	CDD:460719
		BNIP2	2799..2909	CDD:463609	20/114 (18%)
		CRAL_TRIO_2	2921..3058	CDD:463965	44/136 (32%)
RhoGAP68F	NP_001401037.1	CRAL_TRIO_2	119..242	CDD:463965	42/129 (33%)
		RhoGAP-p50rhoGAP	278..473	CDD:239869