DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CYP11B1 and Cyp301a1

DIOPT Version :9

Sequence 1:	NP_000488.3	Gene:	CYP11B1 / 1584	HGNCID:	2591	Length:	503	Species:	Homo sapiens
Sequence 2:	NP_610796.1	Gene:	Cyp301a1 / 36378	FlyBaseID:	FBgn0033753	Length:	553	Species:	Drosophila melanogaster

Alignment Length:	518	Identity:	120/518 - (23%)
Similarity:	206/518 - (39%)	Gaps:	85/518 - (16%)

- Green bases have known domain annotations that are detailed below.

Human    29 ARVPR--------TVLPFEAMP-RRP----GNRWLRLLQIWREQGYEDLHLEVHQTFQELGPIFR 80
            |..||        ..||:..:| .:|    ||.| ||:.|..:....|:...........|.|.|
  Fly    55 ASAPRIHSTSEWQNALPYNQIPGPKPIPILGNTW-RLMPIIGQYTISDVAKISSLLHDRYGRIVR 118

Human    81 YD--LGGAGMVCVMLPEDVEKLQQVDSLHPHRMSLEPWVAY-----RQHRGHKCGVFLLNGPEWR 138
            :.  :|...::.:...:::||..:.:...|.|.|:...|.|     :...|...||..::|..||
  Fly   119 FGGLIGRPDLLFIYDADEIEKCYRSEGPTPFRPSMPSLVKYKSVVRKDFFGDLGGVVGVHGEPWR 183

Human   139 FNRLRLNPEVLSPNAVQRFLPMVDAVARDFSQALKKKVLQNARGSLTLDVQPSIFHYTIEASNLA 203
            ..|.|:...||..:.::|:|..::.:..||  .::.:.|.:....|..|....|..:::|.....
  Fly   184 EFRSRVQKPVLQLSTIRRYLQPLEVITEDF--LVRCENLLDENQELPEDFDNEIHKWSLECIGRV 246

Human   204 LFGERLGLVGHS--PSSASLNFLHALEVMFKSTVQL-------MFMPRSLSRWTSPKVWKEHFEA 259
            ....|||.:..:  |.|.....:.|.:...::...|       .:.|..|  ||. .|...:|..
  Fly   247 ALDTRLGCLESNLKPDSEPQQIIDAAKYALRNVATLELKAPYWRYFPTPL--WTR-YVKNMNFFV 308

Human   260 WDCIFQYGDNCIQKIYQELAFSRPQQYT---SIVAELLLNAELSPDAIKANSMELTAGSVDTTVF 321
            ..|: :|    ||...:.|....|....   |:|.:::| ::.........:::|....:||...
  Fly   309 GVCM-KY----IQSATERLKTQDPSLRAGEPSLVEKVIL-SQKDEKIATIMALDLILVGIDTISM 367

Human   322 PLLMTLFELARNPNVQQALRQESLAAAASISEHPQKATTELPL------LRAALKETLRLYPVGL 380
            .:...|::||..|..||.:.:|    ...:...|....| :||      |:..:||..|:|...:
  Fly   368 AVCSMLYQLATRPVDQQKVHEE----LKRLLPDPNTPLT-IPLLDQMHHLKGFIKEVFRMYSTVI 427

Human   381 FLERVASSDLVLQNYHIPAGTLVRVFLYSLGRNPALFP-----RPERY-------NPQRWLDIRG 433
            ...|....|.|:..|.:|.|.            .|:||     ..|.|       .|:|||..:.
  Fly   428 GNGRTLMEDSVICGYQVPKGV------------QAVFPTIVTGNMEEYVTDAATFRPERWLKPQH 480

Human   434 SG-----RNFYHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHLQVETLTQEDIKMVYSFILRP 491
            .|     ..|..:|:|:|.|.|||||.|:.||.:||..:|::.::| ...:.:....:|:..|
  Fly   481 GGTPGKLHPFASLPYGYGARMCLGRRFADLEMQILLAKLLRNYKLE-YNHKPLDYAVTFMYAP 542

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CYP11B1	NP_000488.3	p450	42..454	CDD:365848	104/458 (23%)
Cyp301a1	NP_610796.1	p450	76..530	CDD:299894	113/483 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0159
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D185685at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820