DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CYP11A1 and Cyp12a4

DIOPT Version :9

Sequence 1:	NP_000772.2	Gene:	CYP11A1 / 1583	HGNCID:	2590	Length:	521	Species:	Homo sapiens
Sequence 2:	NP_650783.2	Gene:	Cyp12a4 / 42294	FlyBaseID:	FBgn0038681	Length:	536	Species:	Drosophila melanogaster

Alignment Length:	535	Identity:	146/535 - (27%)
Similarity:	240/535 - (44%)	Gaps:	48/535 - (8%)

- Green bases have known domain annotations that are detailed below.

Human    12 LVKGCQTFLSAPREGLGRLRVPTGEGAGIST-RSPRPFNEIPSPGDNGWLNLYHFWRETGTHKVH 75
            |::..:..||...:...:..|.|.|....|. ...:||.:||..  |.|..........|.:| :
  Fly    10 LIQSQKATLSLATQKRWQTNVATAEAREDSEWLQAKPFEQIPRL--NMWALSMKMSMPGGKYK-N 71

Human    76 LHHVQNF----QKYGPIYREK--LGNVESVYVIDPEDVALLFKSEG--PN-PERFLIPPWVAYHQ 131
            :..::.|    |.||.|:...  :||...:...:|:|..::|::||  || |..:.:    .||:
  Fly    72 MELMEMFEAMRQDYGDIFFMPGIMGNPPFLSTHNPQDFEVVFRNEGVWPNRPGNYTL----LYHR 132

Human   132 ------YYQRPIGVLLKKSAAWKKDRVALNQEVMAPEATKNFLPLLDAVSRDFVSVLHRRIKKAG 190
                  :||..:||:..:...|...|..:|..:|.|:..:.:...:..|:::||..: ..::...
  Fly   133 EEYRKDFYQGVMGVIPTQGKPWGDFRTVVNPVLMQPKNVRLYYKKMSQVNQEFVQRI-LELRDPD 196

Human   191 SGNYSGDISDDLFRFAFESITNVIFGERQGMLEEV-VNPEAQRFIDAIYQMFHTSVPMLNLPPDL 254
            :.....|..|.:.|:..||::.|...::.|:|:.. ...||.:....:.:.|..|:. |.:.|..
  Fly   197 TLEAPDDFIDTINRWTLESVSVVALDKQLGLLKNSNKESEALKLFHYLDEFFIVSID-LEMKPSP 260

Human   255 FRLFRTKTWKDHVAAWDVIFSKADIYTQNFYWEL---RQKGSVH-HDYRGILYRLLGDSKMSFED 315
            :|..:|...|..:.|.|.|......|.......|   .::|.|. .:.:.:|.:||   |:..:.
  Fly   261 WRYIKTPKLKRLMRALDGIQEVTLAYVDEAIERLDKEAKEGVVRPENEQSVLEKLL---KVDRKV 322

Human   316 IKANVTEMLAGGVDTTSMTLQWHLYEMARNLKVQDMLRAEVLAARHQAQGDMA-TMLQLVPLLKA 379
            ......:||..||||||.|....|..:|:|.:.|..||.||:........:.. ..::.||.|:|
  Fly   323 ATVMAMDMLMAGVDTTSSTFTALLLCLAKNPEKQARLREEVMKVLPNKNSEFTEASMKNVPYLRA 387

Human   380 SIKETLRLHPISVTLQRYLVNDLVLRDYMIPAKTLVQ-VAIYALGREPTFFFDPENFDPTRWL-- 441
            .|||:.||||:.|...|.|..|.||..|.:||.|.|. |.:.||.|: .:|.....|.|.|||
  Fly   388 CIKESQRLHPLIVGNARVLARDAVLSGYRVPAGTYVNIVPLNALTRD-EYFPQASEFLPERWLRS 451

Human   442 SKD----------KNITYFRNLGFGWGVRQCLGRRIAELEMTIFLINMLENFRVEIQHLSDVGTT 496
            .||          |:...|..|.||:|.|.|:|:||.|:|:.:....::.||.||..:.::....
  Fly   452 PKDSESKCPANELKSTNPFVFLPFGFGPRMCVGKRIVEMELELGTARLIRNFNVEFNYPTENAFR 516

Human   497 FNLILMPEKPISFTF 511
            ..||.:|..|:.|.|
  Fly   517 SALINLPNIPLKFKF 531

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CYP11A1	NP_000772.2	p450	52..511	CDD:278495	135/492 (27%)
Cyp12a4	NP_650783.2	p450	72..531	CDD:299894	130/468 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0159
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D185685at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm8467
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.820