Protein Alignment CYP11A1 and Cyp12a5

DIOPT Version :9

• Sequence 1: NP_000772.2
• Gene: CYP11A1 / 1583
• HGNCID: 2590
• Length: 521
• Species: Homo sapiens
• Sequence 2: NP_650782.1
• Gene: Cyp12a5 / 42293
• FlyBaseID: FBgn0038680
• Length: 536
• Species: Drosophila melanogaster
• Alignment Length: 526
• Identity: 142/526 - (26%)
• Similarity: 237/526 - (45%)
• Gaps: 70/526 - (13%)

Human    32 VPTGEGAGISTRSP-----RPFNEIPSPGDNGWLNLYHFWRET----GTHKVHLHHVQNF----Q 83
            |||.|    ....|     :||.|||.      .|:...:.::    |.:| :|..::..    |
  Fly    30 VPTAE----IRNDPEWLQAKPFEEIPK------ANILSLFAKSALPGGKYK-NLEMMEMIDALRQ 83

Human    84 KYGPI--YREKLGNVESVYVIDPEDVALLFKSEGPNPERFLIPPW---VAYHQ------YYQRPI 137
            .||.|  ....:|....|...:|:|..::|::||..|.|    |.   :.||:      ::....
  Fly    84 DYGNIIFLPGMMGRDGLVMTHNPKDFEVVFRNEGVWPFR----PGSDILRYHRTVYRKDFFDGVQ 144

Human   138 GVLLKKSAAWKKDRVALNQEVMAPEATKNFLPLLDAVSRDFVSVLHRRIKKAGSGNYSGDISDDL 202
            |::..:..:|...|..:|..:|.|:..:.:...:..|:::||.:: :.|:.|.:....|:..:.:
  Fly   145 GIIPSQGKSWGDFRSIVNPVLMQPKNVRLYFKKMSQVNQEFVELI-KEIRDASTQEVPGNFLETI 208

Human   203 FRFAFESITNVIFGERQGMLEEV-VNPEAQRFIDAIYQMFHTSVPMLNLPPDLFRLFRTKTWKDH 266
            .|:..||::.|...::.|:|.|. .|.||.:....:.:.|..|.. |.:.|.|:|.|:|...|..
  Fly   209 NRWTLESVSVVALDKQLGLLRESGKNSEATKLFKYLDEFFLHSAD-LEMKPSLWRYFKTPLLKKM 272

Human   267 VAAWDVIFSKADIYTQNFYWELR---QKGSVHHDY-RGILYRLLG-DSKMSFEDIKANVTEMLAG 326
            :...|.:......|.......|.   ::|.|..:: :.:|.:||. |.|::    .....:||..
  Fly   273 LRTMDSVQEVTLKYVDEAIERLEKEAKEGVVRPEHEQSVLEKLLKVDKKVA----TVMAMDMLMA 333

Human   327 GVDTTSMTLQWHLYEMARNLKVQDMLRAEVLAARHQAQGDMA-TMLQLVPLLKASIKETLRLHPI 390
            ||||||.|....|..:|:|.:.|..||.||:........:.. ..::.||.|:|.|||:.|::|:
  Fly   334 GVDTTSSTFTALLLCLAKNPEKQARLREEVMKVLPNKDSEFTEASMKNVPYLRACIKESQRVYPL 398

Human   391 SVTLQRYLVNDLVLRDYMIPAKTLV-QVAIYALGREPTFFFDPENFDPTRWLS------------ 442
            .:...|.|..|.|:..|.:||.|:| .:.|.:|..| .:|..|..|.|.|||.
  Fly   399 VIGNARGLTRDSVISGYRVPAGTIVSMIPINSLYSE-EYFPKPTEFLPERWLRNASDSAGKCPAN 462

Human   443 --KDKNITYFRNLGFGWGVRQCLGRRIAELEMTIFLINMLENFRVEIQHLSDVGTTFNLILMPEK 505
              |.||...|  |.||:|.|.|:|:||.|:|:.:....::.||.||..|.:.......||.:|..
  Fly   463 DLKTKNPFVF--LPFGFGPRMCVGKRIVEMELELGTARLIRNFNVEFNHSTKNAFRSALINLPNI 525

Human   506 PISFTF 511
            |:.|.|
  Fly   526 PLKFKF 531

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CYP11A1	NP_000772.2	p450	52..511	CDD:278495	132/499 (26%)
Cyp12a5	NP_650782.1	p450	81..531	CDD:278495	127/462 (27%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0159
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D185685at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm8467
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.820