Protein Alignment CYP11A1 and shd

DIOPT Version :10

• Sequence 1: NP_000772.2
• Gene: CYP11A1 / 1583
• HGNCID: 2590
• Length: 521
• Species: Homo sapiens
• Sequence 2: NP_996074.1
• Gene: shd / 39592
• FlyBaseID: FBgn0003388
• Length: 540
• Species: Drosophila melanogaster
• Alignment Length: 514
• Identity: 128/514 - (24%)
• Similarity: 213/514 - (41%)
• Gaps: 83/514 - (16%)

Human    43 RSPRPFNEIPSPG-----DNGWLNLYHFWRETGTHKVHLHHVQNFQKYGPIYREKL-GNVESVYV 101
            |..|...:||.|.     ...|:.|..|.|...| |:|..:....::||.|..|.: .||..|::
  Fly    54 RRRRGIWDIPGPKRIPFLGTKWIFLLFFRRYKMT-KLHEVYADLNRQYGDIVLEVMPSNVPIVHL 117

Human   102 IDPEDVALLFKSEGPNPERFLIPPW---VAYHQYYQRP-----IGVLLKKSAAWKKDRVALNQEV 158
            .:.:|:..:.|.....|.|   ||.   |.|.|  .||     :|::.::...|::.|.:|...:
  Fly   118 YNRDDLEKVLKYPSKYPFR---PPTEIIVMYRQ--SRPDRYASVGIVNEQGPMWQRLRSSLTSSI 177

Human   159 MAPEATKNFLPLLDAVSRDFVSVLHRRIKKAGSGNYSGDISDDLFRFAFESITN---------VI 214
            .:|...:||||.|:||..||:.:|..|..           .|.|....||.:.|         ::
  Fly   178 TSPRVLQNFLPALNAVCDDFIELLRARRD-----------PDTLVVPNFEELANLMGLEAVCTLM 231

Human   215 FGERQGMLE-EVVNPE---------AQRFI---DAIYQMFHTSVPMLNLPPDLFRLFRTKTWKDH 266
            .|.|.|.|. :...|:         .|.||   |:.|.:            .|::.|.|||::|.
  Fly   232 LGRRMGFLAIDTKQPQKISQLAAAVKQLFISQRDSYYGL------------GLWKYFPTKTYRDF 284

Human   267 VAAWDVIFSKADIYTQNFYWELRQKGSVHHD----YRGILYRLLGDSKMSFEDIKANVTEMLAGG 327
            ..|.|:|:........:...||::..:...|    .|.|...:|....:...|.|:.:.:.:|.|
  Fly   285 ARAEDLIYDVISEIIDHELEELKKSAACEDDEAAGLRSIFLNILELKDLDIRDKKSAIIDFIAAG 349

Human   328 VDTTSMTLQWHLYEMARNLKVQDMLRAEVLAARHQAQGDMATMLQLVPLLKASIKETLRLHPISV 392
            ::|.:.||.:.|..:..:......:.:|.  ..::....:...|......||.|:|:.||.|.:.
  Fly   350 IETLANTLLFVLSSVTGDPGAMPRILSEF--CEYRDTNILQDALTNATYTKACIQESYRLRPTAF 412

Human   393 TLQRYLVNDLVLRDYMIPAKTLVQVAIYALGREPTFFFDPENFDPTRWLS-KDKNITYFRNLG-- 454
            .|.|.|..|:.|..|.:.|.|:|.........:.:.|...:.|.|.||:. ..:|.|.  |:.
  Fly   413 CLARILEEDMELSGYSLNAGTVVLCQNMIACHKDSNFQGAKQFTPERWIDPATENFTV--NVDNA 475

Human   455 -----FGWGVRQCLGRRIAELEMTIFLINMLENFRVEIQHLSDVGTTFNLILMPEKPIS 508
                 ||.|.|.|.|:|..|:|:.:.|..|:..|  ::..:..:.|.|..:|.|:.|:|
  Fly   476 SIVVPFGVGRRSCPGKRFVEMEVVLLLAKMVLAF--DVSFVKPLETEFEFLLAPKTPLS 532

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CYP11A1	NP_000772.2	CYP11A1	82..508	CDD:410736	115/468 (25%)
shd	NP_996074.1	CYP24A1-like	98..532	CDD:410677	115/467 (25%)